Acta Med. 2009, 52: 57-61

Scavenger Receptor CD163 and Its Biological Functions

Gabriela Onofre, Martina Koláčková, Karolína Jankovičová, Jan Krejsek

Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech Republic

Received May 1, 2009
Accepted June 1, 2009

CD163 is a member of scavenger receptor super family class B of the first subgroup. It is mapped to the region p13 on chromosome 12. Five different isoforms of CD163 have been described, which differ in the structure of their cytoplasmic domains and putative phosporylation sites. This scavenger receptor is selectively expressed on cells of monocytes and macrophages lineage exclusively. CD163 immunological function is essentially homeostatic. It also has other functions because participates in adhesion to endothelial cells, in tolerance induction and tissues regeneration. Other very important function of CD163 is the clearance of hemoglobin in its cell-free form and participation in anti-inflammation in its soluble form, exhibiting cytokine-like functions. We review the biological functions of CD163 which have been discovered until now. It seems apparent from this review that CD163 scavenger receptor can be used as biomarker in different diseases and as a valuable diagnostic parameter for prognosis of many diseases especially inflammatory disorders and sepsis.


This work was supported by Ministry of Education, Czech Republic, project No. MSM0021620812 and Internal Grant Agency of Ministry of Health, Czech Republic, No. NR/9090-4.


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