Acta Med. 2009, 52: 57-61

https://doi.org/10.14712/18059694.2016.105

Scavenger Receptor CD163 and Its Biological Functions

Gabriela Onofre, Martina Koláčková, Karolína Jankovičová, Jan Krejsek

Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech Republic

Received May 1, 2009
Accepted June 1, 2009

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  • Aprilia Andrea, Handono Kusworini, Sujuti Hidayat, Sabarudin Akhmad, Winaris Nuning: sCD163, sCD28, sCD80, and sCTLA-4 as soluble marker candidates for detecting immunosenescence. Immun Ageing 2024, 21. <https://doi.org/10.1186/s12979-023-00405-0>
  • Ren Youliang, Zhang Shiyang, Weeks Jason, Moreno Javier Rangel, He Bin, Xue Thomas, Rainbolt Joshua, Morita Yugo, Shu Ye, Liu Yuting, Kates Stephen L., Schwarz Edward M., Xie Chao: Reduced angiogenesis and delayed endochondral ossification in CD163−/− mice highlights a role of M2 macrophages during bone fracture repair. Journal Orthopaedic Research 2023, 41, 2384. <https://doi.org/10.1002/jor.25564>
  • XU Kui, ZHOU Yan-rong, SHANG Hai-tao, XU Chang-jiang, TAO Ran, HAO Wan-jun, LIU Sha-sha, MU Yu-lian, XIAO Shao-bo, LI Kui: Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus. Journal of Integrative Agriculture 2023, 22, 2188. <https://doi.org/10.1016/j.jia.2022.11.010>
  • Kendall Rebekah L., Ray Jessica L., Hamilton Raymond F., Holian Andrij: Self-replicating murine ex vivo cultured alveolar macrophages as a model for toxicological studies of particle-induced inflammation. Toxicology and Applied Pharmacology 2023, 461, 116400. <https://doi.org/10.1016/j.taap.2023.116400>
  • Wang Youming, Sun Rui, Ge Weigang, Xue Lei, Xu Qianwen, Xu Hui, Li Sujun, Wu Miaomiao, Guo Tiannan, Wang Xingbing: Longitudinal Serum Proteomics Characterization of CD19-CAR-T Cell Therapy for B-Cell Malignancies. J. Proteome Res. 2023, 22, 2985. <https://doi.org/10.1021/acs.jproteome.3c00322>
  • Rambaran Santhuri, Maseko Thando Glory, Lewis Lara, Hassan-Moosa Razia, Archary Derseree, Ngcapu Sinaye, Garrett Nigel, McKinnon Lyle R., Padayatchi Nesri, Naidoo Kogieleum, Sivro Aida: Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection. BMC Immunol 2023, 24. <https://doi.org/10.1186/s12865-023-00558-z>
  • Antunes Mateus da Silva Matias, Sugiyama Fabricia Heloisa Cavicchioli, Gravina Humberto Doriguetto, Castro Ricardo Cardoso, Mercado Francisco Javier Romero, Lima Julia Oliveira de, Fontanari Caroline, Frantz Fabiani Gai: COVID-19 inactivated and non-replicating viral vector vaccines induce regulatory training phenotype in human monocytes under epigenetic control. Front. Cell. Infect. Microbiol. 2023, 13. <https://doi.org/10.3389/fcimb.2023.1200789>
  • Wang Bo, Huang Ying: Antitumor effects of targeted killing of tumor-associated macrophages under photothermal conditions. Lasers Med Sci 2022, 37, 299. <https://doi.org/10.1007/s10103-021-03248-7>
  • Stoian Ana M. M., Rowland Raymond R. R., Brandariz-Nuñez Alberto: Mutations within scavenger receptor cysteine-rich (SRCR) protein domain 5 of porcine CD163 involved in infection with porcine reproductive and respiratory syndrome virus (PRRS). Journal of General Virology 2022, 103. <https://doi.org/10.1099/jgv.0.001740>
  • Wang Lin, Yang Zhihua, Yu Hangxing, Lin Wei, Wu Ruoxi, Yang Hongtao, Yang Kang: Predicting diagnostic gene expression profiles associated with immune infiltration in patients with lupus nephritis. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.839197>
  • Bizymi Nikoleta, Matthaiou Andreas M., Matheakakis Angelos, Voulgari Ioanna, Aresti Nikoletta, Zavitsanou Konstantina, Karasachinidis Anastasios, Mavroudi Irene, Pontikoglou Charalampos, Papadaki Helen A.: New Perspectives on Myeloid-Derived Suppressor Cells and Their Emerging Role in Haematology. JCM 2022, 11, 5326. <https://doi.org/10.3390/jcm11185326>
  • Ghorbani Abozar, Hadifar Shima, Salari Roya, Izadpanah Keramatollah, Burmistrz Michal, Afsharifar Alireza, Eskandari Mohammad Hadi, Niazi Ali, Denes Christopher E., Neely G. Gregory: A short overview of CRISPR-Cas technology and its application in viral disease control. Transgenic Res 2021, 30, 221. <https://doi.org/10.1007/s11248-021-00247-w>
  • Jana Barbara, Kaczmarek Monika M., Romaniewicz Marta, Brzozowska Marta: Profile for mRNA transcript abundances in the pig endometrium where inflammation was induced by Escherichia coli. Animal Reproduction Science 2021, 232, 106824. <https://doi.org/10.1016/j.anireprosci.2021.106824>
  • Su Chia-Ming, Rowland Raymond Robert Richard, Yoo Dongwan: Recent Advances in PRRS Virus Receptors and the Targeting of Receptor–Ligand for Control. Vaccines 2021, 9, 354. <https://doi.org/10.3390/vaccines9040354>
  • Yu Piao, Wei Ruiping, Dong Wenjuan, Zhu Zhenbang, Zhang Xiaoxiao, Chen Yaosheng, Liu Xiaohong, Guo Chunhe: CD163ΔSRCR5 MARC-145 Cells Resist PRRSV-2 Infection via Inhibiting Virus Uncoating, Which Requires the Interaction of CD163 With Calpain 1. Front. Microbiol. 2020, 10. <https://doi.org/10.3389/fmicb.2019.03115>
  • Pan Pengjie, Xu Li, Zhang Hongrong, Liu Yuan, Lu Xiaocheng, Chen Gang, Tang Hailiang, Wu Jiang: A Review of Hematoma Components Clearance Mechanism After Subarachnoid Hemorrhage. Front. Neurosci. 2020, 14. <https://doi.org/10.3389/fnins.2020.00685>
  • Vakili Sarah, Ahooyi Taha Mohseni, Yarandi Shadan S., Donadoni Martina, Rappaport Jay, Sariyer Ilker K.: Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials. Brain Sciences 2020, 10, 424. <https://doi.org/10.3390/brainsci10070424>
  • Xu Huiling, Liu Zehui, Zheng Suya, Han Guangwei, He Fang: CD163 Antibodies Inhibit PRRSV Infection via Receptor Blocking and Transcription Suppression. Vaccines 2020, 8, 592. <https://doi.org/10.3390/vaccines8040592>
  • Álvarez-Estrada Álvaro, Rodríguez-Ferri Elías Fernando, Martínez-Martínez Sonia, Álvarez Belén, Fernández-Caballero Teresa, Domínguez Javier, Gutiérrez-Martín Cesar Bernardo: TLR2, Siglec-3 and CD163 expressions on porcine peripheral blood monocytes are increased during sepsis caused by Haemophilus parasuis. Comparative Immunology, Microbiology and Infectious Diseases 2019, 64, 31. <https://doi.org/10.1016/j.cimid.2019.02.001>
  • Shrivastava Richa, Shukla Nidhi: Attributes of alternatively activated (M2) macrophages. Life Sciences 2019, 224, 222. <https://doi.org/10.1016/j.lfs.2019.03.062>
  • Gao Jinying, Song Lei, Li Dan, Peng Liping, Ding Hui: Clinical value of haptoglobin and soluble CD163 testing for the differential diagnosis of tuberculous and malignant pleural effusions. Medicine 2019, 98, e17416. <https://doi.org/10.1097/MD.0000000000017416>
  • Gross Alden L., Walker Keenan A., Moghekar Abhay R., Pettigrew Corinne, Soldan Anja, Albert Marilyn S., Walston Jeremy D.: Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD. Front. Aging Neurosci. 2019, 11. <https://doi.org/10.3389/fnagi.2019.00229>
  • Chambers Sarah E. J., O'Neill Christina L., Guduric-Fuchs Jasenka, McLoughlin Kiran J., Liew Aaron, Egan Aoife M., O'Brien Timothy, Stitt Alan W., Medina Reinhold J.: The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β. Stem Cells 2018, 36, 834. <https://doi.org/10.1002/stem.2810>
  • Nigenda‐Morales Sergio F., Hu Yibo, Beasley James C., Ruiz‐Piña Hugo A., Valenzuela‐Galván David, Wayne Robert K.: Transcriptomic analysis of skin pigmentation variation in the Virginia opossum (Didelphis virginiana). Molecular Ecology 2018, 27, 2680. <https://doi.org/10.1111/mec.14712>
  • Trancă S., Oever J. T., Ciuce C., Netea M., Slavcovici A., Petrișor C., Hagău N.: sTREM-1, sIL-2Rα, and IL-6, but not sCD163, might predict sepsis in polytrauma patients: a prospective cohort study. Eur J Trauma Emerg Surg 2017, 43, 363. <https://doi.org/10.1007/s00068-016-0678-1>
  • Garton Thomas, Keep Richard F., Hua Ya, Xi Guohua: CD163, a Hemoglobin/Haptoglobin Scavenger Receptor, After Intracerebral Hemorrhage: Functions in Microglia/Macrophages Versus Neurons. Transl. Stroke Res. 2017, 8, 612. <https://doi.org/10.1007/s12975-017-0535-5>
  • Pastor Lucia, Parker Erica, Carrillo Jorge, Urrea Victor, Fuente-Soro Laura, Respeito Durval, Jairoce Chenjerai, Mandomando Inacio, Blanco Julià, Naniche Denise: A Cytokine Pattern That Differentiates Preseroconversion From Postseroconversion Phases of Primary HIV Infection. JAIDS Journal of Acquired Immune Deficiency Syndromes 2017, 74, 459. <https://doi.org/10.1097/QAI.0000000000001272>
  • Detzen Laurent, Chen Steven C. Y., Cheng Bin, Papapanou Panos N., Lalla Evanthia: Increased levels of soluble CD163 in periodontitis patients. J Clinic Periodontology 2017, 44, 585. <https://doi.org/10.1111/jcpe.12731>
  • Burkard Christine, Lillico Simon G., Reid Elizabeth, Jackson Ben, Mileham Alan J., Ait-Ali Tahar, Whitelaw C. Bruce A., Archibald Alan L., Perez Daniel R.: Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function. PLoS Pathog 2017, 13, e1006206. <https://doi.org/10.1371/journal.ppat.1006206>
  • Zhi Yue, Gao Peng, Xin Xiuqin, Li Wei, Ji Lei, Zhang Lin, Zhang Xueyang, Zhang Jie: Clinical significance of sCD163 and its possible role in asthma. Molecular Medicine Reports 2017, 15, 2931. <https://doi.org/10.3892/mmr.2017.6393>
  • Uhlik Mark T., Liu Jiangang, Falcon Beverly L., Iyer Seema, Stewart Julie, Celikkaya Hilal, O'Mahony Marguerita, Sevinsky Christopher, Lowes Christina, Douglass Larry, Jeffries Cynthia, Bodenmiller Diane, Chintharlapalli Sudhakar, Fischl Anthony, Gerald Damien, Xue Qi, Lee Jee-yun, Santamaria-Pang Alberto, Al-Kofahi Yousef, Sui Yunxia, Desai Keyur, Doman Thompson, Aggarwal Amit, Carter Julia H., Pytowski Bronislaw, Jaminet Shou-ching, Ginty Fiona, Nasir Aejaz, Nagy Janice A., Dvorak Harold F., Benjamin Laura E.: Stromal-Based Signatures for the Classification of Gastric Cancer. Cancer Research 2016, 76, 2573. <https://doi.org/10.1158/0008-5472.CAN-16-0022>
  • Minari André Luis Araujo, Oyama Lila Missae, dos Santos Ronaldo Vagner Thomatieli: Downhill Exercise-Induced Changes in Gene Expression Related with Macrophage Polarization and Myogenic Cells in the Triceps Long Head of Rats. Inflammation 2015, 38, 209. <https://doi.org/10.1007/s10753-014-0024-x>
  • Mokarram Nassir, Bellamkonda Ravi V.: A Perspective on Immunomodulation and Tissue Repair. Ann Biomed Eng 2014, 42, 338. <https://doi.org/10.1007/s10439-013-0941-0>
  • Ollikainen Eliisa, Tulamo Riikka, Frösen Juhana, Lehti Satu, Honkanen Petri, Hernesniemi Juha, Niemelä Mika, Kovanen Petri T.: Mast Cells, Neovascularization, and Microhemorrhages are Associated With Saccular Intracranial Artery Aneurysm Wall Remodeling. J Neuropathol Exp Neurol 2014, 73, 855. <https://doi.org/10.1097/NEN.0000000000000105>
  • Jude Claudia, Dejica Doru, Samasca Gabriel, Balacescu Loredana, Balacescu Ovidiu: Soluble CD163 serum levels are elevated and correlated with IL-12 and CXCL10 in patients with long-standing rheumatoid arthritis. Rheumatol Int 2013, 33, 1031. <https://doi.org/10.1007/s00296-012-2459-4>
  • Kondelkova K., Krejsek J., Borska L., Fiala Z., Hamakova K., Andrys C.: Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy. Allergologia et Immunopathologia 2013, 41, 158. <https://doi.org/10.1016/j.aller.2012.02.006>
  • Habal Petr, Jankovicova Karolina, Omran Nedal, Kondelkova Katerina, Krejsek Jan, Mandak Jiri: The dynamics of selected local inflammatory markers to talc in the treatment of malignant pleural effusions. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2013, 157, 311. <https://doi.org/10.5507/bp.2012.095>
  • Bartneck Matthias, Heffels Karl-Heinz, Pan Yu, Bovi Manfred, Zwadlo-Klarwasser Gabriele, Groll Jürgen: Inducing healing-like human primary macrophage phenotypes by 3D hydrogel coated nanofibres. Biomaterials 2012, 33, 4136. <https://doi.org/10.1016/j.biomaterials.2012.02.050>
  • Zhang Zhiren, Zhang Zhi-Yuan, Wu Yuzhang, Schluesener Hermann J.: Lesional Accumulation of CD163+ Macrophages/microglia in Rat Traumatic Brain Injury. Brain Research 2012, 1461, 102. <https://doi.org/10.1016/j.brainres.2012.04.038>
  • Luan Ying-yi, Yao Yong-ming, Sheng Zhi-yong: Update on the Immunological Pathway of Negative Regulation in Acute Insults and Sepsis. Journal of Interferon & Cytokine Research 2012, 32, 288. <https://doi.org/10.1089/jir.2011.0117>
  • Tantawy Azza Abdel Gawad, Adly Amira Abdel Moneam, Ismail Eman Abdel Rahman: Soluble CD163 in young sickle cell disease patients and their trait siblings. Blood Coagulation & Fibrinolysis 2012, 23, 640. <https://doi.org/10.1097/MBC.0b013e3283573a42>
  • Beer Trevor W.: CD163 is not a sensitive marker for identification of atypical fibroxanthoma. J Cutan Pathol 2012, 39, 29. <https://doi.org/10.1111/j.1600-0560.2011.01800.x>
  • Zhang Zhiren, Zhang Zhi-Yuan, Schittenhelm Jens, Wu Yuzhang, Meyermann Richard, Schluesener Hermann J.: Parenchymal accumulation of CD163+ macrophages/microglia in multiple sclerosis brains. Journal of Neuroimmunology 2011, 237, 73. <https://doi.org/10.1016/j.jneuroim.2011.06.006>
  • Kacerovsky Marian, Drahosova Marcela, Andrys Ctirad, Hornychova Helena, Tambor Vojtech, Lenco Juraj, Tosner Jindrich, Krejsek Jan: Amniotic fluid concentrations of soluble scavenger receptor for hemoglobin (sCD163) in pregnancy complicated by preterm premature rupture of the membranes and histologic chorioamnionitis. The Journal of Maternal-Fetal & Neonatal Medicine 2011, 24, 995. <https://doi.org/10.3109/14767058.2010.538453>
  • Kraft-Terry Stephanie D., Stothert Andrew R., Buch Shilpa, Gendelman Howard E.: HIV-1 neuroimmunity in the era of antiretroviral therapy. Neurobiology of Disease 2010, 37, 542. <https://doi.org/10.1016/j.nbd.2009.12.015>
  • Fuentes-Duculan Judilyn, Suárez-Fariñas Mayte, Zaba Lisa C., Nograles Kristine E., Pierson Katherine C., Mitsui Hiroshi, Pensabene Cara A., Kzhyshkowska Julia, Krueger James G., Lowes Michelle A.: A Subpopulation of CD163-Positive Macrophages Is Classically Activated in Psoriasis. Journal of Investigative Dermatology 2010, 130, 2412. <https://doi.org/10.1038/jid.2010.165>
  • Oliveira Lilian J., McClellan Steve, Hansen Peter J., Kaul Rupert: Differentiation of the Endometrial Macrophage during Pregnancy in the Cow. PLoS ONE 2010, 5, e13213. <https://doi.org/10.1371/journal.pone.0013213>
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