Acta Med. 2009, 52: 57-61
https://doi.org/10.14712/18059694.2016.105
Scavenger Receptor CD163 and Its Biological Functions
References
1. EB, Schaer DJ, Walter RB, et al. Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic linage. J Leukoc Biol 2006; 79:312–8.
<https://doi.org/10.1189/jlb.0605309>
2. HD, Zarev PV. Human monocyte CD163 expression inversely correlates with soluble CD163 plasma levels. Cytometry B Clin Cytom 2005; 63B(1):16–22.
3. , C, Ritter M, Orso E, et al. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and anti- inflammatory stimuli. J Leukoc Biol 2000; 67(1):97–103.
<https://doi.org/10.1002/jlb.67.1.97>
4. BO, Dijkstra CD, Van Den Berg TK. The macrophage scavenger receptor CD163. Immunobiol 2005; 210:153–60.
<https://doi.org/10.1016/j.imbio.2005.05.010>
5. W, Dreier J, Sorg C. Only the soluble form of scavenger receptor CD163 acts inhibitory on phorbol ester-activated T-lymphocytes, whereas membranebound protein has no effect. FEBS Letters 2002; 526:93–6.
<https://doi.org/10.1016/S0014-5793(02)03142-3>
6. A, Guillot P, Hakiy N, et al. Alternatively activated macrophages differentially express fibronectin and its splice variants and the extracelullar matrix protein betaIG-H3. Scand J Immunol 2001; 53(4):386–92.
<https://doi.org/10.1046/j.1365-3083.2001.00885.x>
7. JH, Madsen M, Moestrup SK. CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol 2002; 34(4):309–14.
<https://doi.org/10.1016/S1357-2725(01)00144-3>
8. J, Strauss M, Levy NS, et al. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis 2007; 191(1):48–53.
<https://doi.org/10.1016/j.atherosclerosis.2006.04.032>
9. KA, Rassias JA, Wardwell K, et al. Endotoxin induces rapid metalloproteinase- mediated shedding followed by up-regulation of the monocytes hemoglobin scavenger receptor CD163. J Leukoc Biol 2002; 72:711–17.
10. P, Dreier J, Droste A, et al. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). J Immunol 1998; 161(4):1883–90.
11. P, Erpenstein U, Rohdewald P, et al. Biochemical characterization of a glucocorticoid-induced membrane protein (RM3/1) in human monocytes and its application as model system for ranking glucocorticoid potency. Pharm Res 1998; 15:296–302.
<https://doi.org/10.1023/A:1011931021743>
12. P, Sorg C. Soluble CD163 inhibits phorbol ester-induced lymphocytes proliferation. Biochem Biophys Res Commun 2001; 288:841–43.
<https://doi.org/10.1006/bbrc.2001.5845>
13. M, Graversen JH, Jacobsen C, et al. Identification of the haemoglobin scavenger receptor. Nature 2001; 409:198–201.
<https://doi.org/10.1038/35051594>
14. T, Freeman M, Rohrer L, et al. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 1990; 343:531–35.
<https://doi.org/10.1038/343531a0>
15. M, Kudlova M, Kunes P, et al. Early expression of FcγRI (CD64) on monocytes of cardiac surgical patients and higher density of monocyte anti-inflammatory scavenger CD163 receptor in „on-pump“ patients. Med Inflam 2008; 235461.
16. MR, Delangue JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 1996; 42:1589–600.
17. SKA, Micklem KJ, Shaw JM, et al. A new macrophages differentiation antigen which is a member of scavenger receptor superfamily. Eur J Immunol 1993; 23(9):2320–5.
<https://doi.org/10.1002/eji.1830230940>
18. AP. Haptoglobin: a major susceptibility gene for diabetic cardiovascular disease. Israel Med Assoc J 2004; 6(5):308–10.
19. SK, Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Annals Med 2004; 36(5):347–54.
<https://doi.org/10.1080/07853890410033171>
20. HJ, Peterslund NA, Graversen JH, et al. Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma. Blood 2002; 99:378–80.
<https://doi.org/10.1182/blood.V99.1.378>
21. P, Mason JC, Evans BJ, et al. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis. Circ Res 2004; 94:119–26.
<https://doi.org/10.1161/01.RES.0000109414.78907.F9>
22. PA, Goonan KE, Wardwell K, et al. TGF-B regulation of human macrophage scavenger receptor CD163 is Smad3-dependent. J Leukoc Biol 2004; 76:500–8.
<https://doi.org/10.1189/jlb.1203617>
23. D, Pearson A, Krieger M. The SRCR superfamily: a family reminiscent of the Ig superfamily. Trends Biochem Sci 1994; 19(1):5–8.
<https://doi.org/10.1016/0968-0004(94)90165-1>
24. M, Buechler C, Langmann T, et al. Genomic organization and chromosomal localization of the human CD163 (M130) gene: a member of the scavenger receptor cysteine-rich superfamily. Biochem Biophys Res Commun 1999; 260:466–74.
<https://doi.org/10.1006/bbrc.1999.0866>
25. C, Domenech N, Vazquez J, et al. The porcine 2A10 antigen is homologous to human CD163 and related to macrophage differentiation. J Immunol 1999; 162:5230–37.
26. MR, Gronlund J, Padilla O, et al. The scavenger receptor cysteine-rich (SRCR) domain: an ancient and highly conserved protein module of the innate immune system. Crit Rev Immunol 2004; 24(1):1–37.
<https://doi.org/10.1615/CritRevImmunol.v24.i1.10>
27. DJ. The macrophage hemoglobin scavenger receptor (CD163) as a genetically determinated disease modifying pathway in atheroesclerosis. (Letter to the editor). Atherosclerosis 2002; 163:199–201.
<https://doi.org/10.1016/S0021-9150(01)00756-0>
28. DJ, Borreti FS, Schoedon G, et al. Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids. Brit J Haematol 2002; 119(1):239–43.
<https://doi.org/10.1046/j.1365-2141.2002.03790.x>
29. DJ, Schoedon G, Schaffner A. Assignment of the CD163 antigen (CD163) to mouse chromosome 6 band F2 by radiation hybrid mapping. Cytogenet Genome Res 2002; 98:231.
<https://doi.org/10.1159/000069812>
30. M, Levy AP. Regulation of CD163 associated casein kinase II activity is haptoglobin genotype dependent. Moll Cell Biochem 2008; 317:131–35.
<https://doi.org/10.1007/s11010-008-9840-3>
31. TH, Hintz KA, Wardwell K, et al. Development of an ELISA to measure soluble CD163 in biological fluids. J Immunol Methods 2001; 252:25–31.
<https://doi.org/10.1016/S0022-1759(01)00328-3>
32. TH, Högger P, Wahner AE, et al. Human monocytes express CD163, which is upregulated by IL-10 and identical to p155. Cytokine 2000; 12: 1312–21.
<https://doi.org/10.1006/cyto.2000.0720>
33. MM, Tensen CP, Van As JH, et al. Regulation of CD163 on human macrophages: cross-linking of CD163 induces signaling and activation. J Leukoc Biol 1999; 66:858–66.
<https://doi.org/10.1002/jlb.66.5.858>
34. JM, Padilla O, Arman M, et al. The scavenger receptor cysteine-rich superfamily (SRCR–SF). Structure and function of group B members. Immunologia 2000; 19(4):105–21.
35. LK, Pioli PA, Wardwell K, et al. Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptors. J Leukoc Biol 2007; 81:663–71.
<https://doi.org/10.1189/jlb.0706428>
36. I, Roth J, Sorg C. Identification of a novel surface molecule, RM3/1, that contributes to the adhesion of glucocorticoid-induced human monocytes to endothelial cells. Eur J Immunol 1996; 26:2758–63.
<https://doi.org/10.1002/eji.1830261131>
37. G, Neubert R, Stahlmann R, et al. Influence of dexamethasone on the RM 3/1-positive macrophages in the peripheral blood and tissues of a new world monkey (the marmoset Callithrix jacchus). Int Arch Allergy Immunol 1992; 97(2):178–80.
<https://doi.org/10.1159/000236115>
38. G, Voegeli R, Osthoff KS, Sorg C. Monoclonal antibody to a novel differentiation antigen on human macrophages associated with the down-regulatory phase of the inflammatory process. Exp Cell Biol 1987; 55:295–304.
