Thoracic Radiography Characteristics of Drug Sensitive Tuberculosis and Multi Drug Resistant Tuberculosis: A Study of Indonesian National Tuberculosis Prevalence Survey

Sulistijawati, Rosalia Sri; Icksan, Aziza Ghanie; Lolong, Dina Bisara; Nurwidya, Fariz

doi:10.14712/18059694.2019.42

Acta Medica > Archive > 2019, Vol. 62 > Issue 1 > Thoracic Radiography Characteristics of…

Acta Med. 2019, 62: 24-29

https://doi.org/10.14712/18059694.2019.42

Thoracic Radiography Characteristics of Drug Sensitive Tuberculosis and Multi Drug Resistant Tuberculosis: A Study of Indonesian National Tuberculosis Prevalence Survey

Rosalia Sri Sulistijawati^a, Aziza Ghanie Icksan^b, Dina Bisara Lolong^c, Fariz Nurwidya^d

^aDepartment of Radiology, Temanggung Regional Hospital, Central Java, Indonesia
^bDepartment of Radiology, Persahabatan Hospital, Jakarta, Indonesia
^cNational Institute of Health Research and Development, Indonesian Ministry of Health, Jakarta, Indonesia
^dDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia

Received April 23, 2018
Accepted January 22, 2019

Background: Tuberculosis (TB) remains a burden globally, including Indonesia. The primary objective of this study is to reveal the chest radiography characteristic of drug-sensitive TB (DS-TB) and multi-drug resistant TB (MDR-TB) in the Indonesian national tuberculosis prevalence survey 2013–2014. The secondary objective is to explore the correlation and incidence rate of chest radiography lesion of DS-TB and MDR-TB cases. Methods: This is a cross-sectional retrospective analytical studies with national and regional coverage. Samples were selected by stratified multi-stage clustering sampling technique in a population aged ≥15 years old. The diagnosis of TB was based on culture and GeneXpert tests. Results: There were 147 DS-TB and 11 MDR-TB patients that were analyzed in this study. The nodule is the only type of lesions that distinguish MDR-TB and DS-TB. In multivariate analysis of DS-TB, there were 3 significant chest radiography lesions, i.e infiltrate, cavity and consolidation with odd-ratio (OR) of 14, 13, and 3, respectively. In MDR-TB, the only significant lesion is a nodule, with OR of 19. Conclusion: Nodule is the only type of lesions that distinguish MDR-TB and DS-TB. Infiltrate, cavity and consolidation were the types of chest radiography lesions on DS-TB, meanwhile, a nodule was the only significant lesion for MDR-TB.