Acta Med. 2011, 54: 97-101

https://doi.org/10.14712/18059694.2016.28

The Role of Hydrogen Peroxide and Other Reactive Oxygen Species in Wound Healing

Jiří Kanta

Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biochemistry, Czech Republic

Received January 12, 2011
Accepted March 18, 2011

Wound healing is a complex physiological process important for tissue homeostasis. An acute injury initiates massive cell migration, proliferation and differentiation, synthesis of extracellular matrix components, scar formation and remodelling. Blood flow and tissue oxygenation are parts of the complex regulation of healing. Higher organisms utilize molecular oxygen as a terminal oxidant. This way of gaining energy for vital processes such as healing leads to the production of a number of oxygen compounds that may have a defensive or informatory role. They may be harmful when present in high concentrations. Both the lack and the excess of reactive oxygen species may influence healing negatively.

Keywords

Wound healing, Oxygen, ROS.

Funding

This work was supported by a grant from the Ministry of Education, Youth and Sport of the Czech Republic No. MSM 0021620820.

References

61 live references