Acta Med. 2005, 48: 29-34

https://doi.org/10.14712/18059694.2018.25

Membrane Blebbing in Cancer Cells Treated with Various Apoptotic Inducers

Emil Rudolf, Miroslav Červinka

Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biology and Genetics, Hradec Králové, Czech Republic

Received January 1, 2005
Accepted March 1, 2005

References

1. Bailly C. Topoisomerase I poisons and suppressors as anticancer drugs. Curr Med Chem 2000; 7:39–58. <https://doi.org/10.2174/0929867003375489>
2. Coleman ML, Sahai EA, Yeo M, Bosch M, Dewar A, Olson MF. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat Cell Biol 2001; 3:339–45. <https://doi.org/10.1038/35070009>
3. Kravtsov VD, Daniel TO, Koury MJ. Comparative analysis of different methodological approaches to the in vitro study of drug-induced apoptosis. Am J Pathol 1999; 155:1327–39. <https://doi.org/10.1016/S0002-9440(10)65235-2> <PubMed>
4. Kroemer G, Petit P, Zamzami N, Vayssiere JL, Mignotte B. The biochemistry of programmed cell death. The Faseb Journal: Official Publication of the Federation of American Societies For Experimental Biology 1995; 9:1277–87. <https://doi.org/10.1096/fasebj.9.13.7557017>
5. Mills JC, Stone NL, Erhardt J, Pittman RN. Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation. J Cell Biol 1998; 140:627–36. <https://doi.org/10.1083/jcb.140.3.627> <PubMed>
6. Rudolf E, Peychl J, Novak J, Cervinka M. Apoptosis – when the cells begin to dance. Front Biosci 2000; 5:F1–2. <https://doi.org/10.2741/A486>
7. Sargent JM, Elgie AW, Williamson CJ, Hill BT. Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer. Anticancer Drugs 2003; 14:467–73. <https://doi.org/10.1097/00001813-200307000-00013>
8. Sebbagh M, Renvoize C, Hamelin J, Riche N, Bertoglio J, Breard J. Caspase- 3–mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat Cell Biol 2001; 3:346–52. <https://doi.org/10.1038/35070019>
9. Shiratsuchi A, Mori T, Nakanishi Y. Independence of plasma membrane blebbing from other biochemical and biological characteristics of apoptotic cells. J Biochem (Tokyo) 2002; 132:381–86. <https://doi.org/10.1093/oxfordjournals.jbchem.a003233>
10. Song Y, Hoang BQ, Chang DD. ROCK-II-induced membrane blebbing and chromatin condensation require actin cytoskeleton. Exp Cell Res 2002; 278:45–52. <https://doi.org/10.1006/excr.2002.5565>
11. Tomiyoshi G, Horita Y, Nishita M, Ohashi K, Mizuno K. Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing. Genes Cells 2004; 9:591–600. <https://doi.org/10.1111/j.1356-9597.2004.00745.x>
12. van Gorp RM, Heeneman S, Broers JL, Bronnenberg NM, van Dam-Mieras MC, Heemskerk JW. Glutathione oxidation in calcium- and p38 MAPK-dependent membrane blebbing of endothelial cells. Biochim Biophys Acta 2002; 1591: 129–38. <https://doi.org/10.1016/S0167-4889(02)00273-2>
13. Wang L, Eastmond DA. Catalytic inhibitors of topoisomerase II are DNA-damaging agents: induction of chromosomal damage by merbarone and ICRF-187. Environ Mol Mutagen 2002; 39:348–56. <https://doi.org/10.1002/em.10072>
14. Yuste VJ, Bayascas JR, Llecha N, Sanchez-Lopez I, Boix J, Comella JX. The absence of oligonucleosomal DNA fragmentation during apoptosis of IMR-5 neuroblastoma cells: disappearance of the caspase-activated DNase. J Biol Chem 2001; 276:22323–31. <https://doi.org/10.1074/jbc.M100072200>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive