Spectral Characteristics of the Supramolecular Complexes of Polypyrrolic Sensitizers and Cyclodextrin Carriers: Usage in Photodynamic Therapy of Tumors

Huf, Martin; Kolářová, Hana; Bajgar, Robert; Maceček, Jaroslav; Tomečka, Marek; Nevřelová, Pavla; Mosinger, Jiří; Tomek, Pavel; Strnad, Miroslav

doi:10.14712/18059694.2018.113

Acta Medica > Archive > 2004, Vol. 47 > Issue 4 > Spectral Characteristics of the…

Acta Med. 2004, 47: 309-311

https://doi.org/10.14712/18059694.2018.113

Spectral Characteristics of the Supramolecular Complexes of Polypyrrolic Sensitizers and Cyclodextrin Carriers: Usage in Photodynamic Therapy of Tumors

Martin Huf^a, Hana Kolářová^a, Robert Bajgar^a, Jaroslav Maceček^a, Marek Tomečka^a, Pavla Nevřelová^a, Jiří Mosinger^b, Pavel Tomek^c, Miroslav Strnad^d

^aPalacky University Olomouc, Faculty of Medicine, Institute of Medical Biophysics, Olomouc, Czech Republic
^bCharles University in Prague, Faculty of Science, Institute of Inorganic Chemistry, Prague, Czech Republic
^cPalacky University Olomouc, Faculty of Science, Institute of Experimental Physics, Olomouc, Czech Republic
^dPalacky University Olomouc, Faculty of Science, Laboratory of Growth Regulators, Olomouc, Czech Republic

The objective of our work was to describe the photophysical properties (absorption and fluorescence) of the sensitizers TPPS₄, ZnTPPS₄ a PdTPPS₄ and above all the complexes of these sensitizers with cyclodextrin carriers HP-α-CD, HP-β-CD and HP-γ-CD (2–hydroxypropyl-α, β, γ-cyclodextrin) in a suitable environment for the cultivation of cancerous cell lines, and to determine the optimal radioactive conditions for maximizing photodynamic effects in cancerous cells.

Keywords

Polypyrrolic sensitizer, Cyclodextrin carrier, PDT, Absorption spectrum, Fluorescence spectrum.

Funding

This work was supported by a grant from the Palacky University (grant no. 11101101), the GAČR grant no. 203/02/1483, and research plan MŠMT no. 153100008.