Acta Med. 2004, 47: 167-169

1,3–Bis(2–hydroxyiminomethylpyridinium) Propane as the Potential Reactivator of the Acetylcholinesterase Inhibited by Nerve Agents

Kamil Kučaa, Vlastimil Dohnalb

aPurkyně Medical Military Academy in Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic
bMasaryk University in Brno, Faculty of Science, Department of Analytic Chemistry, Brno, Czech Republic

Received October 1, 2003
Accepted June 1, 2004

The oxime K005 [1,3–bis(2–hydroxyiminomethylpyridinium) propane dibromide] for the reactivation of the enzyme acetylcholinesterase (AChE) inhibited by cyclosarin and VX was tested. Its reactivation potency was not better in comparison with the currently used AChE reactivator – pralidoxime. On the other hand, the oxime K005 has its maximum reactivation ability at the concentration 10–4 M, which could be achieved for human use. The maximum concentration of pralidoxime was reached at the concentrations 10–1 M (for cyclosarin) and 10–3 M (for VX) but these concentrations are not available for the use in vivo.


The study was supported by the grant of Ministry of Defense No. ONVLAJEP20031.


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