Acta Med. 2000, 43: 83-89

The Dynamics of the Hexavalent Chromium Induced Apoptotic Patterns in vitro

Emil Rudolf, Jan Peychl, Miroslav Červinka

Charles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biology and Genetics, Hradec Králové, Czech Republic

Received March 1, 2000
Accepted June 1, 2000


1. Bagchi D, Joshi SS, Bagchi M, Balmoori J, Benner EJ, Kuszynski CA, Stohs SJ. Cadmium- and chromium-induced oxidative stress, DNA damage, and apoptotic cell death in cultured human chronic myelogenous leukemic K562 cells, promyelocytic leukemic HL-60 cells, and normal human peripheral blood mononuclear cells. J Biochem Mol Toxicol 2000; 14:33-41. <<33::AID-JBT5>3.0.CO;2-Y>
2. Barry MA, Behnke CA, and Eastman A. Activation of programmed cell death (Apoptosis) by cisplatin, other anticancer drugs, toxins, and hyperthermia. Biochem Pharmacol 1990; 40:2353-62. <>
3. Blakenship LJ, Manning FCR, Orenstein JM, Patierno SR. Apoptosis is the mode of cell death caused by carcinogenic chromium. Toxicol Appl Pharm 1994; 126:75-83. <>
4. Bosman FT. The nuclear matrix in pathology. Wirchows Archiv – An International Journal of Pathology 1999; 435:391-9. <>
5. Bridgewater LC, Manning FCR, Woo ES and Patierno SR. DNA polymerase arrest by adducted trivalent chromium. Mol Carcinog 1994; 9 (3):122-3. <>
6. Cohen G, Sun X-M, Snowden RT, Dinsdale D, Skilleter DN. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem J 1992; 286:331-4. <> <PubMed>
7. Dartsch PC, Hildenbrand S, Kimmel R, Schmahl FW. Investigations on the nephrotoxicity and hepatotoxicity of trivalent and hexavalent chromium compounds. Int Arch Occup Environ Health 1998; 71(Suppl.):40-5.
8. De Flora S, Bagnasco M, Zanucchi P. Genotoxicity of chromium compounds: a review. Mutat Res 1990; 238:99-172. <>
9. Finucane DM, Waterhouse NJ, Amarante-Mendes GP, Cotter TG, Green DR. Collapse of the inner mitochondrial transmembrane potential is not required for apoptosis of HL-60 cells. Exp Cell Res 1999; 251:166-74. <>
10. Kerr, JFR, and Harmon, BV. Definition and incidence of apoptosis: A historical perspective. In Tomei LD, and Cope FO, eds. Apoptosis: The Molecular Basis of Cell Death. New York: Cold Spring Harbor Press, Plainview, 1991:5-29.
11. Methods in Cell Biology. Vol.46 Cell Death. (Schwartz, Osborne, eds) San Diego: Academic Press,1995:459.
12. Rudolf E. Přehled poznatků o toxicitě chromu. Acta Med (Hradec Králové) Suppl 1998; 1:55-65.
13. Singh J, Carlisle, DL, Pritchard, DE, Patierno SR. Chromium-induced genotoxicity and apoptosis: Relationship to chromium carcinogenesis (Review). Oncol Rep 1998; 5:1307–18.
14. Susa N, Ueno S, Furukawa Y, Michiba N, Minoura S. Induction of lipid peroxidation in mice by hexavalent chromium and its relation to the toxicity. Jpn J Vet Sci 1989; 51:1103-10. <>
15. Terada K, Kaziro Y, Satoh T. Analysis of Ras-dependent signals that prevent caspase- 3 activation and apoptosis induced by cytokine deprivation in hematopoietic cells. Biochemical and Biophysical Research Communications 2000; 267:449-55. <>
16. Witenberg B, Kletter Y, Kalir HH, Raviv Z, Fenig E, Nagler A, Halperin D, Fabian I. Ascorbic acid inhibits apoptosis induced by X irradiation in HL60 myeloid leukemia cells. Radiat Res 1999; 152:468-78. <>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal