Acta Med. 2000, 43: 69-73

Dose Dependent Biological Effects of Idarubicin in HL-60 Cells: Alterations of the Cell-Cycle and Apoptosis

Martina Marekováa, Jiřina Vávrováb, Doris Vokurkovác

aCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biochemistry, Hradec Králové, Czech Republic
bPurkyně Military Medical Academy, Hradec Králové, Institute of Radiobiology and Immunology, Hradec Králové, Czech Republic
cUniversity Teaching Hospital in Hradec Králové, Institute of Clinical Immunology and Allergology, Hradec Králové, Czech Republic

Received February 1, 2000
Accepted March 1, 2000


1. Aldridge DR, Radford IR. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Res 1998; 58:2817-24.
2. Berman E, McBride M. Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukaemia cells. Blood 1992; 79(12): 3267-73.
3. Hofmanová J, Kozubík A, Dušek L, Pacherník J. Inhibitors of lipoxygenase metabolism exert synergistic effects with retinoic acid on differentiation of human leukaemia HL-60 cells. Eur J Pharm 1998; 350:273-84. <>
4. Kravtsov V, Fabian I. Automated monitoring of apoptosis in suspension cell cultures. Lab Invest 1996 (2); 74:557-70.
5. Mareková M, Vávrová J, Vokurková D. Apoptosis in human HL-60 induced by ethanol. Gen Physiol Biophys 2000 (in press).
6. Radford IR, Murphy TK. Radiation response of mouse lymphoid and myeloid cell lines. Part 3. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage. Int J Radiat Biol 1994; 65:229-39. <>
7. Schiffer CA, Dodge R, Larson RA. Long-term follow-up of Cancer and Leukaemia Group B studies in acute myeloid leukaemia. Cancer 1997; 80(11 Suppl):2210-4. <<2210::AID-CNCR8>3.0.CO;2-L>
8. Syljuasen, RG, McBride, WH. Radiation-induced apoptosis and cell cycle progression in Jurkat T cells. Radiat Res 1999; 152:328-31. <>
9. Vávrová J, Mareková M, Vokurková D. Lidské hematologické nádorové linie a jejich citlivost k účinkům ionizujícího záření. Voj zdrav Listy 2000 (in press).
10. Wiernik PH, Banks PL, Case DC Jr et al. Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukaemia. Blood 1992; 79(2):313-9.
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ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)