Acta Med. 1999, 42: 127-131

https://doi.org/10.14712/18059694.2019.155

Neuroprotective Effects of Antidotes in Soman-Poisoned Rats

Jiří Kassa, Marie Koupilová

Purkyně Military Medical Academy, Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic

Received April 1, 1999
Accepted September 1, 1999

References

1. Bajgar J. Present views on toxicodynamics of soman poisoning. Acta Med 1996; 39:101-5.
2. Dawson RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 1994; 14:317-31. <https://doi.org/10.1002/jat.2550140502>
3. Fernando JC, Hoskins BH, Ho IK. A striatal serotonergic involvement of the behavioural effects of anticholinesterase organophosphates. Eur J Pharmacol 1984; 98:129-32. <https://doi.org/10.1016/0014-2999(84)90118-3>
4. Frantík E, Hornychová M. Clustering of neurobehavioral measured of toxicity. Homeostasis 1995; 36:19-24.
5. Hornychová M, Frantík E, Kubát J, Formánek J. Neurotoxicity profile of supermethrin, a new pyrethroid insecticide. Cent. Eur J Publ Health 1995; 3:210-8.
6. Kadar T, Cohen G, Sahar R, Ajkalay D, Shapira S. Long-term study of brain lesions following soman, in comparison to DFP and metrazol poisoning. Hum Exp Toxicol 1992; 11: 517-23. <https://doi.org/10.1177/096032719201100613>
7. Kassa J. Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats. Toxicology 1995; 101:167-74. <https://doi.org/10.1016/0300-483X(95)03091-S>
8. Kassa J, Cabal J, Bajgar J, Szinicz L. The choice: HI-6, pralidoxime or obidoxime against nerve agents? ASA Newsletter 1997; 97-4:16-8.
9. Kassa J. A comparison of the therapeutic efficacy of conventional and modern oximes against supralethal doses of highly toxic organophosphates in mice. Acta Med (Hradec Králové) 1998; 41: 19-21.
10. Kok A. REM sleep pathway and anticholinesterase intoxication: a mechanism for nerve agent-induced, central respiratory failure. Med Hypotheses 1993; 41:141-9. <https://doi.org/10.1016/0306-9877(93)90061-T>
11. Koplovitz I, Romano JA, Stewart JR. Assessment of motor performance decrement following soman poisoning in mice. Drug Chem Toxicol 1989; 12:221-35. <https://doi.org/10.3109/01480548908999155>
12. Koupilová M, Vachek J, Fusek J, Patočka J, Herink J. Neurotoxic effects of soman in animal experimental poisoning and the influence of therapy. Homeostasis 1996; 37:266.
13. Lallement G, Clarencon D, Bronchier G, Baubichon D, Galonnier M, Blanchet G, Mestries J-C. Efficacy of atropine/pralidoxime/diazepam or atropine/HI- 6/prodiazepam in primates intoxicated by soman. Pharmacol Biochem Behav 1997; 56: 325-32. <https://doi.org/10.1016/S0091-3057(96)00292-4>
14. Leadbeater L, Inns RH, Rylands JM. Treatment of poisoning by soman. Fundam Appl Toxicol 1985; 5:S225-31. <https://doi.org/10.1016/0272-0590(85)90132-0>
15. Lemercier G, Carpentier P, Sentenac-Roumanou H, Morelis P. Histological and biochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathol 1983; 61:123-9. <https://doi.org/10.1007/BF00697391>
16. Marrs TC. Organophosphate poisoning. Pharmacol Ther 1993; 58:51-66. <https://doi.org/10.1016/0163-7258(93)90066-M>
17. McDonough JHJr, Smith RF, Smith CD. Behavioral correlates of soman-induced neuropathology: Deficits in DRL acquisition. Neurobehav Toxicol Teratol 1986; 8:179-87.
18. McDonough JHJr, Shih T-M. Neuropharmacological mechanisms of nerve agentinduced seizure and neuropathology. Neurosci Biobehav Rev 1997; 21:559-79. <https://doi.org/10.1016/S0149-7634(96)00050-4>
19. Moser VC, Tilson H, McPhail RC et al. The IPCS collaborative study on neurobehavioral screening methods: II. Protocol design and testing procedures. Neurotoxicology 1997; 18:929-38.
20. Petras JM. Neurology and neuropathology of soman-induced brain injury: an overview. J Exp Anal Behav 1994; 61:319-29. <https://doi.org/10.1901/jeab.1994.61-319> <PubMed>
21. Sidell FR. Clinical considerations in nerve agent intoxication. In: Somani SM, ed. Chemical Warfare Agents. New York: Academic Press, 1992; p. 335.
22. Slechta DA. Behavioral measures of neurotoxicity. Neurotoxicology 1989; 10:271-96.
23. Taylor P. Anticholinesterase agents. In: Hardman JG, Limbird LE, eds. The Pharmacological Basis of Therapeutics (9th ed.). New York: Macmillan, 1996; p.129.
24. van Helden HPM, Busker RW, Melchers BPC, Bruijnzeel PLB. Pharmacological effects of oximes: how relevant are they? Arch Toxicol 1996; 70:779-86. <https://doi.org/10.1007/s002040050340>
25. Worek F, Szinicz L. Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethansulfonate versus HI-6 dichloride. Pharmacol Toxicol 1993; 72:13-21. <https://doi.org/10.1111/j.1600-0773.1993.tb01332.x>
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