Acta Med. 1998, 41: 13-17

Effect of Long Lasting Terguride Treatment on Mutual Relationship Between Glycide and Lipid Parameters in SHR/N-cp Koletsky Rats

Věroslav Goldaa, Jiřina Hilgertováb

aInstitute of Experimental Neurosurgery, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic
bLaboratory for Endocrinology and Metabolism, Charles University, Faculty of Medicine, Prague, Czech Republic

Received December 1, 1997
Accepted January 1, 1998

Experiments were performed in the genetically hypertensive obese rats of Koletsky type (SHR/N-cp) and in their lean siblings. The effect of long lasting terguride treatment on glycide and lipid metabolism was monitored.Terguride decreases insulinemia in all groups of rats. In all groups of rats terguride increases tolerance glucose.Terguride increases insulin binding to erythrocytes in all groups of rats except SHR/N-cp obese females.The mentioned drug decreases plasma triglycerides in SHR/N-cp obese females. On the other hand, this drug increases plasma triglycerides in SHR/N-cp obese males. Correlation between basal glycemia and insulin binding to erythrocytes as well as between triglycerides and insulinemia which was found in control SHR/N-cp lean males is missing under the terguride treatment. Similarly, correlation between plasma triglycerides and insulinemia, glucose tolerance and insulinemia,basal glycemia and insulinemia,plasma triglycerides and basal glycemia are missing under the terguride treatment in SHR/N-cp lean females.Under the terguride treatment there appears correlation between insulin binding to erythrocytes and basal glycemia.We found in SHR/N-cp obese males opposite changes in number of correlations when we compare control and terguride animals. While in controls only one correlation was detected, i.e.,correlation between glucose tolerance and insulin binding to erythrocytes, then under the terguride treatment there appear correlations when basal glycemia is computed versus insulin binding to erythrocytes or to glucose tolerance and/or to triglycerides. Moreover, there is under the terguride treatment correlation insulin binding to erythrocytes versus plasma triglycerides or versus insulinemia.While in SHR/N-cp lean of both sexes and in SHR/N-cp obese males profound changes in the number of statistically significant correlation coefficients were found when controls are compared with animals under the terguride treatment, the different picture we found in SHR/N-cp obese females,i.e.,under the terguride treatment correlation basal glycemia versus insulinemia or versus insulin binding to erythrocytes as well as correlation insulin binding to erythrocytes versus insulinemia is present in controls as well as in terguride treated animals. In comparison with controls under terguride only two correlations are missing, i.e., glucose tolerance versus insulinemia or versus insulin binding to erythrocytes.


This paper was supported by Internal Grant Agency of Ministry of Health of the Czech Republic No 3684-3.


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