Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients

Král, Bohuslav; Krejsek, Jan; Paráková, Zdena; Kopecký, Otakar; Vokurková, Doris; Derner, Václav; Toušková, Miroslava

doi:10.14712/18059694.2020.46

Acta Medica > Archive > 1997, Vol. 40 > Issue 3 > Some Serum Activity Markers of Airways…

Acta Med. 1997, 40: 61-70

https://doi.org/10.14712/18059694.2020.46

Some Serum Activity Markers of Airways Inflammation in Difficult-To-Control Asthma Patients

Bohuslav Král^a, Jan Krejsek^a, Zdena Paráková^a, Otakar Kopecký^b, Doris Vokurková^b, Václav Derner^b, Miroslava Toušková^b

^aIInd Department of Medicine, Charles University, Faculty of Medicine, Hradec Králové, Czech Republic
^bDepartment of Clinical Immunology and Allergy, University Teaching Hospital, Hradec Králové, Czech Republic

Received May 1, 1997
Accepted June 1, 1997

The main aim of the present study was a search for a characteristic serum marker of inflammatory activity in the airways of asthmatics with difficult-to-control disease. Therefore, serum levels of interleukin-4 (IL-4), serum low-affinity Fc Epsilon Receptor II (sFcER II), Interferon-gamma (INF-gamma) Immunoglobulin-E (IgE), Interleukin-2 (IL-2), serum Interleukin Receptor 2 (sIL-2R) and Intercellular Adhesion Molecule-1 (sICAM-1) were measured in 2 groups of asthmatics: 1-26 patients with difficult-to-control asthma (DTCA), 2-22 asthmatics, minimally symptomatic (MSA). Results: No significant difference in either measured parameters between the DTCA and MSA group in peripheral blood samples was found. Conclusion: The above mentioned serum markers of T- and B-cell activation as well as the serum ICAM-1 level are not sensitive enough to determine the type, activity and severity of the inflammatory process in the asthmatic airways.