Acta Med. 2025, 68: 134-141
https://doi.org/10.14712/18059694.2026.4
Surgical Management of Spondylodiscitis: A Single-Center Retrospective Analysis of 126 Cases
References
1. KY. Comparison of pyogenic spondylitis and tuberculous spondylitis. Asian Spine J. 2014; 8(2): 216–23.
<https://doi.org/10.4184/asj.2014.8.2.216>
<PubMed>
2. S, Walter N, Heidemanns S. [18F] FDG PET/CT imaging is associated with lower in-hospital mortality in patients with pyogenic spondylodiscitis: a registry-based analysis of 29,362 cases. Antibiotics (Basel). 2024; 13(9): 860.
<https://doi.org/10.3390/antibiotics13090860>
<PubMed>
3. K, Anazor F, Iyer S, Rajagopal TS. Spondylodiscitis in adults: diagnosis and management. Br J Hosp Med (Lond). 2022; 83(1): 1–9.
4. L, Baron S, Rusch E, et al. Epidemiology of vertebral osteomyelitis in France: analysis of hospital-discharge data 2002–2003. Epidemiol Infect. 2008; 136(5): 653–60.
<https://doi.org/10.1017/S0950268807008850>
<PubMed>
5. M, Mende KC, Mohme M, et al. Influence of microbiological diagnosis on the clinical course of spondylodiscitis. Infection. 2021; 49(4): 723–32.
<https://doi.org/10.1007/s15010-021-01642-5>
<PubMed>
6. D, Lopes N, Rodrigues D. Diagnosis and treatment of spondylodiscitis: insights from a five-year single-center study. Cureus. 2024; 16(1): e74192.
7. M, Carl B, Schmöckel V, Völlger B, Nimsky C, Saß B. Neurosurgical management and outcome parameters in 237 patients with spondylodiscitis. Brain Sci. 2021; 11(8): 1019.
<https://doi.org/10.3390/brainsci11081019>
<PubMed>
8. CL, Villanacci A, Di Stefano F. Spondylodiscitis and its mimickers: a pictorial review. Biomedicines. 2024; 12(1): 2566.
<https://doi.org/10.3390/biomedicines12112566>
<PubMed>
9. L, Dinh A, Ghout I, et al. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial. Lancet. 2015; 385(9971): 875–82.
<https://doi.org/10.1016/S0140-6736(14)61233-2>
10. J, Lemaignen A, Ghout I, Therby A, Belmatoug N, Dinh A. Pyogenic vertebral osteomyelitis of the elderly: characteristics and outcomes. PLoS One. 2017; 12(12): e0188470.
<https://doi.org/10.1371/journal.pone.0188470>
<PubMed>
11. M, Pedersen C, Jensen TG, Lassen AT. Increasing incidence of pyogenic spondylodiscitis: a 14-year population-based study. J Infect. 2014; 68(4): 313–20.
<https://doi.org/10.1016/j.jinf.2013.11.011>
12. UJ, Bae JY, Kim SE, Kim CJ, Kang SJ, Jang HC. Comparison of pyogenic postoperative and native vertebral osteomyelitis. Spine J. 2019; 19(5): 880–7.
<https://doi.org/10.1016/j.spinee.2018.11.012>
13. A, Ghout I, Dinh A, Gras G, Fantin B, Zarrouk V. Characteristics of and risk factors for severe neurological deficit in patients with pyogenic vertebral osteomyelitis: a case-control study. Medicine (Baltimore). 2017; 96(21): e6387.
<https://doi.org/10.1097/MD.0000000000006387>
<PubMed>
14. KH, Cho OH, Lee JH, Park JS, Ryu KN, Park SY. Optimal duration of antibiotic therapy in patients with hematogenous vertebral osteomyelitis at low risk and high risk of recurrence. Clin Infect Dis. 2016; 62(10): 1262–9.
<https://doi.org/10.1093/cid/ciw098>
15. E, Autore G, Formica VM, Pambianco V, Colangelo D, Cauda R. New classification for the treatment of pyogenic spondylodiscitis: validation study on a population of 250 patients with a follow-up of 2 years. Eur Spine J. 2017; 26(Suppl 4): 479–88.
<https://doi.org/10.1007/s00586-017-5043-5>
16. M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016; 315(8): 801–10.
<https://doi.org/10.1001/jama.2016.0287>
<PubMed>
17. P, Gülec G, Bajwa AA, Issa MA, Oskouian RJ, Chapman JR. Decompression only versus fusion in octogenarians with spinal epidural abscesses: early complications, clinical and radiological outcome with 2-year follow-up. Neurosurg Rev. 2022; 45(4): 2765–74.
<https://doi.org/10.1007/s10143-022-01805-4>
<PubMed>
18. JS, Kim TH. Recurrence rates and associated factors after early spinal instrumentation for pyogenic spondylodiscitis: a nationwide cohort study of 2148 patients. J Clin Med. 2022; 11(12): 3356.
<https://doi.org/10.3390/jcm11123356>
<PubMed>
19. GA, Raheem HQ, Qutub A, Salman L, Alnemari A, Alkhani A. Management of pyogenic spondylodiscitis following nonspinal surgeries: a tertiary care center experience. Int J Spine Surg. 2021; 15(3): 527–36.
<https://doi.org/10.14444/8080>
<PubMed>
20. F, Metaxiotis D, Saloupis P, Pazarlis K, Igoumenou VG. Operative treatment of adult pyogenic spondylodiscitis: a retrospective study of 32 cases. Cureus. 2021; 13(5): e14820.
21. JJ, Sadrameli SS, Sulhan S, De la Garza Ramos R, Yassari R. The role of instrumentation in the surgical treatment of spondylodiscitis and spinal epidural abscess: a single-center retrospective cohort study. Int J Spine Surg. 2022; 16(1): 68–76.
<https://doi.org/10.14444/8178>
<PubMed>
22. JH, Lee SY, Jung JS, Jang SH, Seo JY, Chung SK. Outcome following spinal instrumentation in haemodialyzed patients with pyogenic spondylodiscitis. J Bone Joint Surg Br. 2019; 101-B(1): 11–8.
23. DG, Buchholz AL, Sure DR, Buell TJ, Nguyen JH, Chen CJ. Presentation and outcomes after medical versus surgical treatment of spontaneous infectious spondylodiscitis: a systematic review and meta-analysis. Global Spine J. 2019; 9(3): 291–308.
24. PJ, Wang SF, Tsai TT, Li YD, Chiu PY. Percutaneous endoscopic interbody debridement and fusion for pyogenic lumbar spondylodiscitis: comparison with percutaneous endoscopic drainage and debridement. Neurospine. 2021; 18(4): 780–9.
<https://doi.org/10.14245/ns.2142640.320>
<PubMed>
25. N, Patel K, Rossiter N. The role of diskectomy in reducing infectious complications after surgery for lumbar spondylodiscitis. J Neurol Surg A Cent Eur Neurosurg. 2022; 83(6): 522–8.
26. B, Shiban E. Pyogenic spinal infection. J Neurol Surg A Cent Eur Neurosurg. 2022; 83(3): 261–74.
27. LJ, Alentado VJ, Tanenbaum JE, Lee BS, Steinmetz MP, Krishnaney AA. Assessment of postoperative outcomes in spinal epidural abscess following surgical decompression. Spine J. 2019; 19(5): 827–33.
<https://doi.org/10.1016/j.spinee.2018.12.006>
28. RS, Zhang HJ, Alsoof D, Goodwin CR, Sciubba DM, De la Garza Ramos R. Beta-lactam-resistant Staphylococcus aureus in spinal osteomyelitis and spondylodiscitis: current landscape in antibiotic resistance, treatment, and complications. J Neurosurg Spine. 2023; 39(1): 82–92.
29. J, Freeman WD, Wharen RE, Hocker S. MRSA spinal epidural abscess as a neurosurgical and infectious disease emergency with unresolved antimicrobial solution. Case Rep Infect Dis. 2019; 2019: 7413089.
30. E, Taccari F, Autore G, Giovannenze F, Pambianco V, Cauda R. Multidisciplinary management of pyogenic spondylodiscitis: epidemiological and clinical features, prognostic factors and long-term outcomes in 207 patients. Eur Spine J. 2018; 27(Suppl 2): 229–36.
<https://doi.org/10.1007/s00586-018-5598-9>
31. S, Page PS, Greeneway GP, Brooks NP. Primary spinal infections: a retrospective review of instrumentation use and graft selection. Surg Neurol Int. 2022; 13: 446.
<https://doi.org/10.25259/SNI_1073_2022>
<PubMed>
32. J, Emmerson I, Cullinan M, Narayanan M, Klejnow E, Narayanan N. Pyogenic spondylodiscitis: risk factors for adverse clinical outcome. Med Sci (Basel). 2018; 6(4): 96.
33. AH, Shrestha NK, Allison GM, Keller SC, Bhavan KP, Zurlo JJ. 2018 Infectious Diseases Society of America clinical practice guideline for the management of outpatient parenteral antimicrobial therapy. Clin Infect Dis. 2019; 68(1): e1–e35.
<https://doi.org/10.1093/cid/ciy745>
34. EF, Kanj SS, Kowalski TJ, et al. 2015 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults. Clin Infect Dis. 2015; 61(6): e26–e46.
<https://doi.org/10.1093/cid/civ482>
35. K, Arpi M, Lindblad BE, Pedersen LN, Christensen JJ, Andersen CO. Broad-range PCR as a supplement to culture for detection of bacterial pathogens in patients with clinically diagnosed spinal infection. Scand J Infect Dis. 2008; 40(10): 772–7.
<https://doi.org/10.1080/00365540802119994>
36. AL, Dickerson EC, Gomez-Hassan DM, Cinti SK, Srinivasan A. Yield of image-guided needle biopsy for infectious discitis: a systematic review and meta-analysis. AJNR Am J Neuroradiol. 2017; 38(10): 2021–7.
<https://doi.org/10.3174/ajnr.A5337>
<PubMed>


