Eyelid Radiotherapy-Treated Basal and Squamous Cell Carcinomas: A Case Series

Athanasiadis, Ioannis; Konstantinidis, Aristeidis; Panagiotopoulou, Eirini-Kanella; Bakirtzis, Minas; Koukourakis, Michael; Labiris, Georgios

doi:10.14712/18059694.2025.20

Acta Medica > Archive > 2025, Vol. 68 > Issue 2 > Eyelid Radiotherapy-Treated Basal and…

Acta Med. 2025, 68: 58-62

https://doi.org/10.14712/18059694.2025.20

Eyelid Radiotherapy-Treated Basal and Squamous Cell Carcinomas: A Case Series

Ioannis Athanasiadis^a

, Aristeidis Konstantinidis^a

, Eirini-Kanella Panagiotopoulou^a

, Minas Bakirtzis^a

, Michael Koukourakis^b

, Georgios Labiris^a

^aDepartment of Ophthalmology, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
^bDepartment of Radiotherapy and Oncology, University Hospital of Alexandroupolis, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

Received February 1, 2025
Accepted July 29, 2025

Introduction: This case report aims to showcase the successful application of electron hypofractionated radiotherapy in the treatment of eyelid basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Cases Presentation: Two cases are presented involving a 91-year-old Greek female with nodular BCC and an 88-year-old Greek male with ulcerative SCC. Both cases were treated with electron 10MeV irradiation using an ELEKTA 5-15MV linear accelerator. In the first case, a patient with advanced dementia presented with left-upper-eyelid nodular BCC. Following confirmation through biopsy and imaging, hypofractionated electron-beam radiotherapy was chosen, leading to gradual recession of the lesion and no recurrence at the one-year follow-up. In the second case, an elderly male with comorbidities had right-upper-eyelid ulcerative SCC. After systemic evaluation ruled out metastasis, the patient underwent hypofractionated radiotherapy, resulting in unexpected lesion shrinkage, resolution, and absence of recurrence at the 6-month and one-year follow-ups. Conclusions: Hypofractionated electron-beam radiotherapy emerges as an effective and well-tolerated alternative for eyelid tumors, particularly in cases where surgical excision is challenging or contraindicated.