Acta Med. 2025, 68: 50-57

https://doi.org/10.14712/18059694.2025.19

Comparative Analysis of Immaturity CD Markers Expression between Pediatric and Adult Acute Lymphoblastic Leukemia: Insights and Implications for Diagnostic and Therapeutic Strategies

Ihsan Mardan Al-Badrana, Ahmed Mardan Al-Badranb

aDepartment of Pathology and Forensic Medicine, Al-Zahraa College of Medicine, University of Basrah, Basrah, Iraq
bDepartment of Radiation Oncology, Basra Oncology Center, Basra Directorate of Health, Basrah, Iraq

Received December 24, 2024
Accepted June 25, 2025

References

1. Olteanu H. Lymphoblastic Leukemia/Lymphoma. In: Molina TJ, ed. Hematopathology. Encyclopedia of Pathology. Cham: Springer, 2020: 307–15.
2. He Y. Dissecting oncogenic signaling by Bcr/Abl and Notch (Dissertation). Philadelphia, Pennsylvania, United States: University of Pennsylvania, 2002. 141 pp.
3. Gębarowska K, Mroczek A, Kowalczyk JR, Lejman M. MicroRNA as a Prognostic and Diagnostic Marker in T-Cell Acute Lymphoblastic Leukemia. Int J Mol Sci. 2021 May 18; 22(10): 5317. <https://doi.org/10.3390/ijms22105317> <PubMed>
4. Yaghmaie M, Ahmadvand M, Nejati Safa A, Pashaiefar H. Genetic, Hematologic and Psychological Aspects of Leukemia. In: Mehdipour P, ed. Cancer Genetics and Psychotherapy. Cham: Springer, 2017: 667–755.
5. Mohseni M, Uludag H, Brandwein JM. Advances in biology of acute lymphoblastic leukemia (ALL) and therapeutic implications. Am J Blood Res. 2018 Dec 10; 8(4): 29–56.
6. Ratti S, Lonetti A, Follo MY, et al. B-ALL Complexity: Is Targeted Therapy Still A Valuable Approach for Pediatric Patients? Cancers (Basel). 2020 Nov 24; 12(12): 3498. <https://doi.org/10.3390/cancers12123498> <PubMed>
7. Porwit A, Béné MC. Multiparameter flow cytometry applications in the diagnosis of mixed phenotype acute leukemia. Cytometry B Clin Cytom. 2019 May; 96(3): 183–94. <https://doi.org/10.1002/cyto.b.21783>
8. Emmrich S, Trapp A, Tolibzoda Zakusilo F, et al. Characterization of naked mole-rat hematopoiesis reveals unique stem and progenitor cell patterns and neotenic traits. EMBO J. 2022 Aug 1; 41(15): e109694. <https://doi.org/10.15252/embj.2021109694> <PubMed>
9. Mahapatra S, Mace EM, Minard CG, Forbes LR, et al. High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults. PLoS One. 2017 Aug 2; 12(8): e0181134. <https://doi.org/10.1371/journal.pone.0181134> <PubMed>
10. Gupta M, Monga L, Mehrotra D, Chhabra S, Singhal S, Sen R. Immunophenotypic Aberrancies in Acute Leukemia: A Tertiary Care Centre Experience. Oman Med J. 2021 Jan 31; 36(1): e218. <https://doi.org/10.5001/omj.2021.03> <PubMed>
11. van Grotel M, Meijerink JP, van Wering ER, et al. Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences. Leukemia. 2008 Jan; 22(1): 124–31. <https://doi.org/10.1038/sj.leu.2404957>
12. Karrman K, Johansson B. Pediatric T-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2017 Feb; 56(2): 89–116. <https://doi.org/10.1002/gcc.22416>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive