Relationship Between XRCC1 Arg399gln Polymorphism and Risk of Luminal Subtype Breast Cancer in Bali, Indonesia

Sutadarma, I Wayan Gede; Supadmanaba, I Gede Putu; Adiputra, Putu Anda Tusta; Devy, Anggi Amanda Triana; Indrakusuma, Anak Agung Bagus Putra; Sasmana, I Gede Aswin Parisya

doi:10.14712/18059694.2025.14

Acta Medica > Archive > 2025, Vol. 68 > Issue 1 > Relationship Between XRCC1 Arg399gln…

Acta Med. 2025, 68: 21-25

https://doi.org/10.14712/18059694.2025.14

Relationship Between XRCC1 Arg399gln Polymorphism and Risk of Luminal Subtype Breast Cancer in Bali, Indonesia

I Wayan Gede Sutadarma^a,b, I Gede Putu Supadmanaba^a,b

, Putu Anda Tusta Adiputra^c

, Anggi Amanda Triana Devy^d

, Anak Agung Bagus Putra Indrakusuma^d, I Gede Aswin Parisya Sasmana^d

^aDepartment of Biochemistry, Faculty of Medicine, Udayana University, Indonesia
^bDepartment of Clinical Nutrition, Faculty of Medicine, Udayana University – Prof. Dr. IGNG Ngoerah General Hospital, Denpasar, Indonesia
^cDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Udayana University – Prof. Dr. IGNG Ngoerah General Hospital, Denpasar, Indonesia
^dFaculty of Medicine, Udayana University, Indonesia

Received December 19, 2024
Accepted April 24, 2025

Background: Breast cancer is the second leading cause of cancer-related death and the most common type of cancer in women. Recent studies have shown that the development of carcinogenesis is influenced by impaired XRCC1 expression. Therefore, research on the relationship between the XRCC1 Arg399Gln polymorphism and the luminal subtype of breast cancer is important so that it can be used as a reference for further research development. Methods: This study lasted for 12 months at the Integrated Biomedical Laboratory and Biochemistry Laboratory, Faculty of Medicine, Udayana University. The samples consisted of 30 samples of stored biological material from previous studies with a case-control study design. The status of the XRCC1 Arg399Gln polymorphism was determined by performing PCR on blood samples. Furthermore, the samples were analyzed with SPSS version 25.0. Results: The number of samples in this study was 15 cases and 15 controls with the majority aged > 50 years. The results of the analysis showed that differences in age groups, menstrual status, and cancer grade were significantly associated with breast cancer subtypes (p < 0.05). Based on the results of sequencing and bivariate analysis, the XRCC1 Arg399Gln polymorphism acted as a protective risk factor for the development of luminal subtype breast cancer (OR = 0.182; p = 0.028). Conclusion: XRCC1 Arg399Gln polymorphism is associated with the risk of luminal subtype breast cancer in Bali.

Keywords

breast cancer, polymorphism, luminal subtype, XRCC1 Arg399Gln.

Funding

We thank Udayana University for supporting this research financially through the research grant that is provided on the Penelitian Unggulan Program Studi (PUPS) research schema. We also thank the Faculty of Medicine, Udayana University; Prof. Dr. IGNG Ngoerah Hospital, and RISE- Search Oncology Research Group for supporting this re- search.