The Choroid after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Christou, Evita Evangelia; Katsanos, Andreas; Georgalas, Ilias; Kozobolis, Vassilios; Kalogeropoulos, Christos; Stefaniotou, Maria

doi:10.14712/18059694.2022.24

Acta Medica > Archive > 2022, Vol. 65 > Issue 3 > The Choroid after Half-Dose Photodynamic…

Acta Med. 2022, 65: 89-98

https://doi.org/10.14712/18059694.2022.24

The Choroid after Half-Dose Photodynamic Therapy in Chronic Central Serous Chorioretinopathy

Evita Evangelia Christou^a, Andreas Katsanos^a, Ilias Georgalas^b, Vassilios Kozobolis^c, Christos Kalogeropoulos^a, Maria Stefaniotou^a

^aDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
^bFirst Department of Ophthalmology, General Hospital of Athens G. Gennimatas, Medical School, National and Kapodistrian University of Athens, Greece
^cDepartment of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Patras, Patras, Greece

Received May 11, 2022
Accepted November 14, 2022

Purpose: To characterize choroidal structure and vasculature after half-dose verteporfin photodynamic therapy (hd-vPDT) in eyes with chronic central serous chorioretinopathy using Enhanced Depth Imaging Optical Coherence Tomography (EDI OCT) and Optical Coherence Tomography Angiography (OCT-A). Methods: This prospective case-control study included 10 eyes. Choroid was examined before and at 1 month following hd-vPDT. We measured choroidal thickness (CT) at subfoveal area and at 750 μm nasal and temporal of fovea and thickness of Haller and choriocapillaris/Sattler layers. Whole (WA), luminal (LA) and interstitial area (IA) at EDI-OCT, and perfusion density at OCT-A were analyzed. The unaffected fellow eyes were used for comparisons. Results: Mean CT at subfoveal area and at 750 μm nasal and temporal of fovea, values of Haller and choriocapillaris/Sattler layers and those of WA, LA and IA were reduced, while PD increased at 1 month after hd-vPDT (all p < 0.001). There was a significant (p < 0.05) negative correlation (ρ = −0.658) between PD and post-treatment logMARVA. None of analyzed parameters reached values of unaffected fellow eye. Conclusion: Following hd-vPDT, choroidal thickness with both luminal and interstitial components markedly decreased, while perfusion of choriocapillaris improved.