Acta Med. 2021, 64: 8-14

https://doi.org/10.14712/18059694.2021.2

The Effects of Ranitidine Treatment on the Risk of Necrotizing Enterocolitis in Preterm Infants: A Case-Control Study

Zlatan ZvizdicaID, Emir Milisica, Asmir Jonuzia, Sabina Terzicb, Denisa Zvizdicc, Semir Vranicd,eID

aClinic of Pediatric Surgery, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina
bPediatric Clinic, Neonatal Intensive Care Unit, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina
cEye Clinic, Department of Pediatric Ophthalmology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina
dBiomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar
eCollege of Medicine, QU Health, Qatar University, Doha, Qatar

Received July 17, 2020
Accepted November 26, 2020

References

1. Fitzgibbons SC, Ching Y, Yu D, Carpenter J, et al. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg 2009; 44(6): 1072–5; discussion 5–6. <https://doi.org/10.1016/j.jpedsurg.2009.02.013>
2. Frost BL, Modi BP, Jaksic T, Caplan MS. New Medical and Surgical Insights Into Neonatal Necrotizing Enterocolitis: A Review. JAMA Pediatr 2017; 171(1): 83–8. <https://doi.org/10.1001/jamapediatrics.2016.2708>
3. Alganabi M, Lee C, Bindi E, Li B, Pierro A. Recent advances in understanding necrotizing enterocolitis. F1000Res 2019; 8: F1000 Faculty Rev-107.
4. Arnold M, Moore SW, Sidler D, Kirsten GF. Long-term outcome of surgically managed necrotizing enterocolitis in a developing country. Pediatr Surg Int 2010; 26(4): 355–60. <https://doi.org/10.1007/s00383-010-2583-8>
5. Sheng Q, Lv Z, Xu W, et al. Short-term surgical outcomes of preterm infants with necrotizing enterocolitis: A single-center experience. Medicine (Baltimore) 2016; 95(30): e4379. <https://doi.org/10.1097/MD.0000000000004379> <PubMed>
6. Lin H, Mao S, Shi L, Tou J, Du L. Clinical characteristic comparison of low birth weight and very low birth weight preterm infants with neonatal necrotizing enterocolitis: a single tertiary center experience from eastern China. Pediatr Surg Int 2018; 34(11): 1201–7. <https://doi.org/10.1007/s00383-018-4339-9>
7. Deshpande G, Jape G, Rao S, Patole S. Benefits of probiotics in preterm neonates in low-income and medium-income countries: a systematic review of randomised controlled trials. BMJ Open 2017; 7(12): e017638. <https://doi.org/10.1136/bmjopen-2017-017638> <PubMed>
8. Neu J, Walker WA. Necrotizing enterocolitis. N Engl J Med 2011; 364(3): 255–64. <https://doi.org/10.1056/NEJMra1005408> <PubMed>
9. Kuusela AL, Ruuska T, Karikoski R, et al. A randomized, controlled study of prophylactic ranitidine in preventing stress-induced gastric mucosal lesions in neonatal intensive care unit patients. Crit Care Med 1997; 25(2): 346–51. <https://doi.org/10.1097/00003246-199702000-00025>
10. Bergholz TM, Whittam TS. Variation in acid resistance among enterohaemorrhagic Escherichia coli in a simulated gastric environment. J Appl Microbiol 2007; 102(2): 352–62. <https://doi.org/10.1111/j.1365-2672.2006.03099.x>
11. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol 2005; 96(2): 94–102. <https://doi.org/10.1111/j.1742-7843.2005.pto960202.x>
12. Dial MS. Proton pump inhibitor use and enteric infections. Am J Gastroenterol 2009; 104(Suppl 2): S10–6.
13. Canani RB, Terrin G. Gastric acidity inhibitors and the risk of intestinal infections. Curr Opin Gastroenterol 2010; 26(1): 31–5. <https://doi.org/10.1097/MOG.0b013e328333d781>
14. Canani RB, Cirillo P, Roggero P, et al. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community- acquired pneumonia in children. Pediatrics 2006; 117(5): e817–20. <https://doi.org/10.1542/peds.2005-1655>
15. Terrin G, Canani RB, Passariello A, Caoci S, De Curtis M. Inhibitors of gastric acid secretion drugs increase neonatal morbidity and mortality. J Matern Fetal Neonatal Med 2012; 25(Suppl 4): 85–7. <https://doi.org/10.3109/14767058.2012.714975>
16. Patole S. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis: a case of excessive collateral damage? Pediatrics 2006; 117(2): 531–2. <https://doi.org/10.1542/peds.2005-2230>
17. Terrin G, Passariello A, De Curtis M, et al. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics 2012; 129(1): e40–5. <https://doi.org/10.1542/peds.2011-0796>
18. More K, Athalye-Jape G, Rao S, Patole S. Association of inhibitors of gastric acid secretion and higher incidence of necrotizing enterocolitis in preterm very low-birth-weight infants. Am J Perinatol 2013; 30(10): 849–56.
19. Singh N, Dhayade A, Mohamed AL, Chaudhari TV. Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit. Int J Pediatr 2016; 2016: 9649162. <https://doi.org/10.1155/2016/9649162> <PubMed>
20. Havranek T, Thompson Z, Carver JD. Factors that influence mesenteric artery blood flow velocity in newborn preterm infants. J Perinatol 2006; 26(8): 493–7. <https://doi.org/10.1038/sj.jp.7211551>
21. Zvizdic Z, Milisic E, Jonuzi A, Terzic S, Zvizdic D. The contribution of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched casecontrol study. Turk J Pediatr 2019; 61(4): 513–9. <https://doi.org/10.24953/turkjped.2019.04.007>
22. Gephart SM, Spitzer AR, Effken JA, Dodd E, Halpern M, McGrath JM. Discrimination of GutCheck(NEC): a clinical risk index for necrotizing enterocolitis. J Perinatol 2014; 34(6): 468–75. <https://doi.org/10.1038/jp.2014.37> <PubMed>
23. Mohamed A, Shah PS. Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data. Pediatrics 2012; 129(3): 529–40. <https://doi.org/10.1542/peds.2011-2872>
24. Alidjinou EK, Lazrek M, Schuffenecker I, et al. Necrotizing Enterocolitis Cases Associated with Nosocomial Enterovirus Transmission in a Neonatal Unit. Pediatr Infect Dis J 2018; 37(9): 954–7. <https://doi.org/10.1097/INF.0000000000001928>
25. Santana RNS, Santos VS, Ribeiro-Junior RF, et al. Use of ranitidine is associated with infections in newborns hospitalized in a neonatal intensive care unit: a cohort study. BMC Infect Dis 2017; 17(1): 375. <https://doi.org/10.1186/s12879-017-2482-x> <PubMed>
26. Walsh MC, Kliegman RM. Necrotizing enterocolitis: treatment based on staging criteria. Pediatr Clin North Am 1986; 33(1): 179–201. <https://doi.org/10.1016/S0031-3955(16)34975-6> <PubMed>
27. Eaton S, Rees CM, Hall NJ. Current Research on the Epidemiology, Pathogenesis, and Management of Necrotizing Enterocolitis. Neonatology 2017; 111(4): 423–30. <https://doi.org/10.1159/000458462>
28. Guillet R, Stoll BJ, Cotten CM, et al. Association of H2-blocker therapy and higher incidence of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2006; 117(2): e137–42. <https://doi.org/10.1542/peds.2005-1543>
29. Lin HC, Su BH, Chen AC. H2-blocker therapy and necrotizing enterocolitis for very low birth weight preterm infants. Pediatrics 2006; 118(4): 1794–5; author reply 5–6. <https://doi.org/10.1542/peds.2006-1607>
30. Bilali A, Galanis P, Bartsocas C, Sparos L, Velonakis E. H2-blocker therapy and incidence of necrotizing enterocolitis in preterm infants: a case-control study. Pediatr Neonatol 2013; 54(2): 141–2. <https://doi.org/10.1016/j.pedneo.2013.01.011>
31. Chandrasekaran M, Fleming P. Question 1: does the use of ranitidine increase the risk of NEC in preterm infants? Arch Dis Child 2014; 99(4): 390–2. <https://doi.org/10.1136/archdischild-2013-304973>
32. Santos VS, Freire MS, Santana RNS, Martins-Filho PRS, Cuevas LE, Gurgel RQ. Association between histamine-2 receptor antagonists and adverse outcomes in neonates: A systematic review and meta- analysis. PloS One 2019; 14(4): e0214135. <https://doi.org/10.1371/journal.pone.0214135> <PubMed>
33. Green DS, Abdel-Latif ME, Jones LJ, Lui K, Osborn DA. Pharmacological interventions for prevention and treatment of upper gastrointestinal bleeding in newborn infants. Cochrane Database Syst Rev 2019; 7: CD011785.
34. Samuels N, van de Graaf RA, de Jonge RCJ, Reiss IKM, Vermeulen MJ. Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies. BMC Pediatrics 2017; 17(1): 105. <https://doi.org/10.1186/s12887-017-0847-3> <PubMed>
35. Zvizdic Z, Heljic S, Firdus A, Jonuzi A, Zvizdic D. Relationship of nosocomial infections with the development of necrotizing enterocolitis in preterm infants. Mater Sociomed 2014; 26(1): 4–6. <https://doi.org/10.5455/msm.2014.26.4-6> <PubMed>
36. Beck-Sague CM, Azimi P, Fonseca SN, et al. Bloodstream infections in neonatal intensive care unit patients: results of a multicenter study. Pediatr Infect Dis J 1994; 13(12): 1110–6. <https://doi.org/10.1097/00006454-199412000-00008>
37. Graham PL, Begg MD, Larson E, Della-Latta P, Allen A, Saiman L. Risk factors for late onset gram-negative sepsis in low birth weight infants hospitalized in the neonatal intensive care unit. Pediatr Infect Dis J 2006; 25(2): 113–7. <https://doi.org/10.1097/01.inf.0000199310.52875.10>
38. Conroy S, McIntyre J. The use of unlicensed and off-label medicines in the neonate. Semin Fetal Neonatal Med 2005; 10(2): 115–22. <https://doi.org/10.1016/j.siny.2004.11.003>
39. Neu J. Gastrointestinal maturation and implications for infant feeding. Early Hum Dev 2007; 83(12): 767–75. <https://doi.org/10.1016/j.earlhumdev.2007.09.009>
40. Moharana AK, Bhattacharya SK, Mediratta PK, Sharma KK. Possible role of histamine receptors in the central regulation of immune responses. Indian J Physiol Pharmacol 2000; 44(2): 153–60.
41. van der Pouw Kraan TC, Snijders A, Boeije LC, et al. Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. J Clin Invest 1998; 102(10): 1866–73. <https://doi.org/10.1172/JCI3692> <PubMed>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive