Acta Med. 2020, 63: 119-123

https://doi.org/10.14712/18059694.2020.29

Clinical Probe of Cyp2C8*2 Mutants in a Malaria Hyperendemic Zone: Evidence from North-Central, Nigeria

Olalere Shittua, Olufunke Adenike Opeyemia, Olumuyiwa Babagbemi Omoteshob, Oluwatosin Fakayodec, Nnaemeka Asogwad, Opeyemi Margaret Adeniyia, Ifeoluwa Margaret Fatobaa, Kayode Muritala Salawue, Olusola Ajibayef, Olarewaju Abdulkareem Babamalea, Oluyinka Ajibola Iyiolag, Olusola Isaac Aremuh

aParasitology Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
bUnilorin Clinic, University of Ilorin, Ilorin, Nigeria
cChildren Specialist Hospital, Centre Igboro, Ilorin, Nigeria
dDepartment of Biochemistry, University of Ilorin, Ilorin, Nigeria
eDepartment of Pharmacognosy and Drug Development, University of Ilorin, Ilorin, Nigeria
fBiochemistry Division, Nigerian Institute of Medical Research, Lagos, Nigeria
gCell Biology and Genetics Unit, Department of Zoology, University of Ilorin, Ilorin, Nigeria
hDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria

Received September 24, 2019
Accepted June 22, 2020

References

1. Jamison D, Feachem R, Makgoba M, et al.: The International Bank for Reconstruction and Development. Washington (DC): The World Bank 2006.
2. Petersen I, Eastman R, Lanzer M. Drug‐resistant malaria: Molecular mechanisms and implications for public health. FEBS Letters 2011; 585(11): 1551–62. <https://doi.org/10.1016/j.febslet.2011.04.042>
3. Kumar SC. Drug Resistance in Malaria. In: Drug Resistance in Bacteria, Fungi, Malaria, and Cancer. Springer 2017: 429–47.
4. Antony HA, Parija SC. Antimalarial drug resistance: An overview. Tropical Parasitology 2016; 6(1): 30.
5. Paganotti GM, Gallo BC, Verra F, et al. Human genetic variation is associated with Plasmodium falciparum drug-resistance. J Infect Dis 2011; 204: 1772–8. <https://doi.org/10.1093/infdis/jir629>
6. Gil JP, Gil BE. CYP2C8 and antimalaria drug efficacy. Pharmacogenomics 2007; 8(2): 187–98. <https://doi.org/10.2217/14622416.8.2.187> <PubMed>
7. Parkinson A, Kazmi F, Buckley DB, Yerino P, Ogilvie BW, Paris BL. System-dependent outcomes during the evaluation of drug candidates as inhibitors of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) enzymes: human hepatocytes versus liver microsomes versus recombinant enzymes. Drug Metabolism and Pharmacokinetics 2010; 25(1): 16–27. <https://doi.org/10.2133/dmpk.25.16>
8. Kalia S, Dutz JP. New concepts in antimalarial use and mode of action in dermatology. Dermatologic therapy 2007, 20(4):160-174. <https://doi.org/10.1111/j.1529-8019.2007.00131.x> <PubMed>
9. Adehin A, Bolaji OO, Kennedy MA. Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population. Drug Metabolism and Pharmacokinetics 2017; 32(3): 189–91. <https://doi.org/10.1016/j.dmpk.2016.09.001>
10. Marwa KJ, Schmidt T, Sjögren M, Minzi OMS, Kamugisha E, Swedberg G. Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations. Malaria Journal 2014; 13: 420. <https://doi.org/10.1186/1475-2875-13-420> <PubMed>
11. Paganotti GM, Gramolelli S, Tabacchi F. Distribution of human CYP2C8* 2 allele in three different African populations. Malaria Journal 2012; 11: 125. <https://doi.org/10.1186/1475-2875-11-125> <PubMed>
12. Carrier Frequency Calculator (http://www.perinatology.com/calculators/Hardy-Weinberg.htm).
13. Lin JT, Juliano JJ, Wongsrichanalai C. Drug-Resistant Malaria: The Era of ACT. Current Infectious Disease Report 2010; 12(3): 165–73. <https://doi.org/10.1007/s11908-010-0099-y> <PubMed>
14. Adehin A, Bolaji OO, Kennedy MA. Polymorphisms in CYP2C8 and CYP3A5 genes in the Nigerian population. Drug Metabolism and Pharmacokinetics 2016; 30: 1–3.
15. Fernandez P, Zeigler-Johnson CM, Spangler E, et al.: Androgen metabolism gene polymorphisms, associations with prostate cancer risk and pathological characteristics: a comparative analysis between south african and senegalese men. Prostate Cancer 2012: 798634.
16. Bains RK. African variation at Cytochrome P450 genes: Evolutionary aspects and the implications for the treatment of infectious diseases. Evolution, Medicine, and Public Health 2013; 2013(1): 118–34. <https://doi.org/10.1093/emph/eot010> <PubMed>
17. Peko SM, Ntoumi F, Vouvoungui C. Distribution of the cytochrome P450 CYP2C8*2 allele in Brazzaville, Republic of Congo. International Journal of Infectious Diseases 2019, 85: 49–53. <https://doi.org/10.1016/j.ijid.2019.04.035>
18. White NJ. Malaria. Edinburgh, United Kingdom: Elsevier Science Limited 2003.
19. VandenBrink BM, Foti RS, Rock DA, Wienkers LC, Wahlstrom JL. Evaluation of CYP2C8 inhibition in vitro: utility of montelukast as a selective CYP2C8 probe substrate. Drug Metabolism and Disposition 2011; 39: 1546–54. <https://doi.org/10.1124/dmd.111.039065>
20. Backman JT, Filppula AM, Niemi M, Neuvonen PJ. Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions. Pharmacological Reviews 2016; 68(1): 168–241. <https://doi.org/10.1124/pr.115.011411>
21. Greenwood BM, Fidock DA, Kyle DE, et al. Malaria: progress, perils, and prospects for eradication. Journal of Clinical Investigation 2008; 118(4): 1266–76. <https://doi.org/10.1172/JCI33996> <PubMed>
22. Dai D, Zeldin DC, Blaisdell JA, et al. Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid. Pharmacogenetics 2001; 11: 597–607. <https://doi.org/10.1097/00008571-200110000-00006>
23. Gil JP, Gil Berglund E. CYP2C8 and antimalaria drug efficacy. Pharmacogenomics 2007; 8(2): 187–98. <https://doi.org/10.2217/14622416.8.2.187> <PubMed>
24. White N. Antimalarial drug resistance and combination chemotherapy. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences 1999: 354: 739–49. <https://doi.org/10.1098/rstb.1999.0426> <PubMed>
25. Agomo CO, Oyibo WA, Sutherland C, Hallet R, Oguike M. Assessment of Markers of Antimalarial Drug Resistance in Plasmodium falciparum Isolates from Pregnant Women in Lagos, Nigeria. PloS One 2016; 11(1): e0146908–e0146908. <https://doi.org/10.1371/journal.pone.0146908> <PubMed>
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