Acta Med. 2020, 63: 10-17

Epidemiology of Melanoma in the Czech Republic in East Bohemia in the Period 2002–2017 and the Effect of the Annual Sunshine Exposure

Jarmila Čelakovskáa, Josef Bukačb, Lenka Čákováa, Marie Šimkováa, Eva Jandováa

aDepartment of Dermatology and Venereology Faculty Hospital and Medical Faculty of Charles University, Hradec Králové, Czech Republic
bDepartment of Medical Biophysics, Medical Faculty of Charles University, Hradec Králové, Czech Republic

Received November 1, 2019
Accepted February 4, 2020


1. Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA. Increasing burden of melanoma in the United States. J Investig Dermatol 2009; 129(7): 1666–74. <> <PubMed>
2. Surveillance, Epidemiology, and End Results (SEER). Program Cancer Statistics Review, 1975–2013, National Cancer Institute [Internet] Nov, 2015. SEER data submission [cited posted to the SEER web site, 2016 Apr]. Available from:
3. Erdei E, Torres SM. A new understanding in the epidemiology of melanoma. Exp Rev Anticancer Ther 2010; 10(11): 1811–23. <> <PubMed>
4. Giblin AV, Thomas JM. Incidence, mortality and survival in cutaneous melanoma. J Plast Reconstr Aesthet Surg 2007; 60: 32–40. <>
5. Garbe, C, Leiter U. Melanoma epidemiology and trends. Clin Dermatol 2009; 27: 3–9. <>
6. Welch HG, Woloshin, S, Schwartz LM. Skin biopsy rates and incidence of melanoma: population based ecological study. BMJ 2005; 331: 481. <> <PubMed>
7. Dennis LK. Analysis of the melanoma epidemic, both apparent and real: data from the 1973 through 1994 surveillance, epidemiology, and end results program registry. Arch Dermatol 1999; 135: 275–80.
8. Hall HI, Jamison P, Fulton JP, Clutter G, Roffers S, Parrish P. Reporting cutaneous melanoma to cancer registries in the United States. J Am Acad Dermatol 2003; 49: 624–30. <>
9. Jemal A, Saraiya M, Patel P, et al. Recent trends in cutaneous melanoma incidence and death rates in the United States, 1992–2006. J Am Acad Dermatol 2011; 65 (5 suppl 1): S17-S25, e1–3. <>
10. Mounessa JS, Caravaglio, JV, Dellavalle RP. Comparison of regional and state differences in melanoma rates in the United States: 2003 vs 2013. AMA Dermatol 2017; 153: 345–7.
11. Koh HK, Geller AC, Miller, DR, Grossbart TA, Lew RA. Prevention and early detection strategies for melanoma and skin cancer. Current status Arch Dermatol 1996; 132(4): 436–43. <>
12. van der Leest, R, Flohil S, Arends L, de Vries E, Nijsten, T. Risk of subsequent cutaneous malignancy in patients with prior melanoma: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2015; 29(6): 1053–62. <>
13. D’Orazio J, Jarrett S, Amaro-Ortiz A, Scott T. UV radiation and the skin. Int J Mol Sci 2013; 14(6): 12222–48. <> <PubMed>
14. Colantonio S, Bracken MB, Beecker J. The association of indoor tanning and melanoma in adults: systematic review and meta-analysis. J Am Acad Dermatol 2014; 70(5): 847–57. <>
15. Pawlak MT, Bui M, Amir M, Burkhardt DL, Chen AK, Dellavalle RP. Legislation restricting access to indoor tanning throughout the world. Arch Dermatol 2012; 148(9): 1006–12. <>
16. Bevona C, Goggins W, Quinn T, Fullerton J, Tsao H. Cutaneous melanomas associated with nevi. Arch Dermatol 2003; 139(12): 1620–4. <>
17. Haenssle HA, Mograby N, Ngassa A, et al. Association of patient risk factors and frequency of nevus-associated cutaneous melanomas. JAMA Dermatol 2016; 152(3): 291–8. <>
18. Whiteman DC, Stickley M, Watt P, Hughes MC, Davis MB, Green AC. Anatomic site, sun exposure, and risk of cutaneous melanoma. J Clin Oncol 2006; 24(19): 3172–7. <>
19. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin 2017; 67(1): 7–30. <>
20. Rastrelli M, Tropea S, Rossi C, Alaibac, M. Melanoma, Epidemiology, Risk Factors, Pathogenesis, Diagnosis and Classification. In vivo 2014; 28(6): 1005–11.
21. Buettner PG, Leiter U, Eigentler TK, Garbe, C. Development of prognostic factors and survival in cutaneous melanoma over 25 years: an analysis of the Central Malignant Melanoma Registry of the German Dermatological Society. Cancer 2005; 103: 616–24. <>
22. Coory M, Baade P, Aitken C, Smithers M, McLeod GR, Ring I. Trends for in situ and invasive melanoma in Queensland, Australia, 1982– 2002. Cancer Causes Control 2006; 17: 21–7. <>
23. Troxel DB. Pitfalls in the diagnosis of malignant melanoma: findings of a risk management panel study. Am J Surg Pathol 2003; 27: 1278– 83. <>
24. Frangos JE, Duncan LM, Piris A, et al. Increased diagnosis of thin superficial spreading melanomas: a 20-year study. J Am Acad Dermatol 2012; 67: 387–94. <>
25. Glusac JE. The melanoma ‘epidemic’, a dermatopathologist’s perspective. J Cutan Pathol 2011; 38: 264–7. <>
26. Shuster S. Malignant melanoma: how error amplification by screening creates spurious disease. Br J Dermatol 2009; 161: 977–9. <>
27. Weyers W. The ‘epidemic’ of melanoma between under- and overdiagnosis. J Cutan Pathol 2012; 39: 9–16. <>
28. Lakhani NA, Saraiya M, Thompson TD, King SC, Guy GP Jr. Total body skin examination for skin cancer screening among U.S. adults from 2000 to 2010. Prev Med 2014; 61: 75–80. <> <PubMed>
29. Geller AC, Zhang Z, Sober AJ, et al. The first 15 years of the American Academy of Dermatology skin cancer screening programs: 1985– 1999. J Am Acad Dermatol 2003; 48: 34–41. <>
30. Hiatt RA, Fireman B. The possible effect of increased surveillance on the incidence of malignant melanoma. Prev Med 1986; 15: 652–60. <>
31. Criscione VD, Weinstock MA. Melanoma thickness trends in the United States, 1988–2006. J Invest Dermatol 2010, 130: 793–7. <>
32. Chen ST, Geller AC, Tsao H. Update on the epidemiology of melanoma. Curr Dermatol Rep 2013; 2: 24–34. <> <PubMed>
33. Beddingfield EC.3rdThe melanoma epidemic: res ipsa loquitur. Oncologist 2003; 8: 459–65. <>
34. Erickson C, Driscoll MC. Melanoma epidemic: facts and controversies. Clin Dermatol 2010; 28: 281–6. <>
35. Gilchrest BA, Eller MS, Geller AC, Yaar M. The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 1999; 340: 1341–8. <>
36. Dennis LK, Vanbeek MJ, Beane Freeman LE, Smith BJ, Dawson DV, Coughlin JA. Sunburns and risk of cutaneous melanoma: does age matter? A comprehensive meta-analysis. Ann Epidemiol 2008; 18: 614–27. <> <PubMed>
37. Armstrong BK, Cust AC. Sun exposure and skin cancer, and the puzzle of cutaneous melanoma: a perspective on Fears et al. Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. American Journal of Epidemiology 1977; 105: 420–427. Cancer Epidemiol 2017; 48: 147–56. <>
38. Lazovich, D, Vogel RI, Berwick M, Weinstock MA, Warshaw EM, Anderson KE. Melanoma risk in relation to use of sunscreen or other sun protection methods. Cancer Epidemiol Biomarkers Prev 2011; 20: 2583–93. <> <PubMed>
39. Green AC, Williams GM, Logan V, Strutton, G.M.Reduced melanoma after regular sunscreen use: randomized trial follow-up. J Clin Oncol 2011; 29: 257–63. <>
40. Robinson JK, Rigel DS, Amonette RA. Trends in sun exposure knowledge, attitudes, and behaviors: 1986 to 1996. J Am Acad Dermatol 1997; 37: 179–86. <>
41. Gandini, S, Sera F, Cattaruzza,MS, et al. Meta-analysis of risk factors for cutaneous melanoma: I. Common and atypical naevi. Eur J Cancer 2005; 41: 28–44. <>
42. Gandini S, Sera F, Cattaruzza MS, et al. Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer 2005; 41: 45–60. <>
43. Autier P, Doré JF, Gefeller O, et al. Melanoma risk and residence in sunny areas. EORTC Melanoma Co‐operative Group. European Organization for Research and Treatment of Cancer. Br J Cancer 1997; 76: 1521–4. <> <PubMed>
44. Moan J, Dahlback A. The relationship between skin cancers, solar radiation and ozone depletion. Br J Cancer 1992; 65: 916–21. <> <PubMed>
45. lwood JM, Jopson J. Melanoma and sun exposure: an overview of published studies. Int J Cancer 1997; 73: 198–203.
46. Swerdlow AJ. Incidence of malignant melanoma of the skin in England and Wales and its relationship to sunshine. Br Med J 1979; 2(6201): 1324–7. <> <PubMed>
47. Caini S, Gandini S, Sera F, et al. Meta-analysis of risk factors for cutaneous melanoma according to anatomical site and clino-pathological variant. Eur J Cancer 2009; 45: 3054–63. <>
48. Olsen CM, Zens MS, Green AC, et al. Biologic markers of sun exposure and melanoma risk in women: pooled case-control analysis. Int J Cancer 2011; 129: 713–23. <> <PubMed>
49. Whiteman DC, Pavan WJ, Bastian BC. The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin. Pigment Cell Melanoma Res 2011; 24(5): 879–97. <> <PubMed>
50. Liu F, Bessonova L, Taylor TH, Ziogas A, Meyskens FL Jr, Anton-Culver H. A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important. Pigment Cell Melanoma Res 2013; 26(1): 128–35. <> <PubMed>
51. Liu-Smith F, Farhat AM, Arce A, et al. Sex differences in the association of cutaneous melanoma incidence rates and geographic ultraviolet light exposure. J Am Acad Dermatol 2017; 76(3): 499–505, e3. <> <PubMed>
52. Liu-Smith F, Ziogas A. An age-dependent interaction between sex and geographical UV index in melanoma risk. J Am Acad Dermatol 2017; pii: S0190-9622(17)327482.
53. Howlader N, Noone AM, Krapcho M (eds). SEER cancer statistics review, 1975–2014, National Cancer Institute. Bethesda, MD,, based on November 2016 SEER data submission, posted to the SEER web site, April 2017.
54. Joosse A, Collette S, Suciu S, Nijsten T, Patel PM, Keilholz U, et al. Sex is an independent prognostic indicator for survival and relapse /progression-free survival in metastasized stage III to IV melanoma: a pooled analysis of five European organisation for research and treatment of cancer randomized controlled trials. J Clin Oncol 2013; 31(18): 2337–46. <>
55. Courtenay WH. Constructions of masculinity and their influence on men’s well-being: a theory of gender and health. Soc Sci Med 2000; 50(10): 1385–401. <>
56. Watts CG, Madronio C, Morton RL, et al. Clinical features associated with individuals at higher risk of melanoma: a population-based study. JAMA Dermatol 2017; 153(1): 23–9. <>
57. Barysch MJ, Levesque MP, Cheng P, et al. Coexpression of SOX10/ CD271 (p75(NTR)) and beta-galactosidase in large to giant congenital melanocytic nevi of pediatric patients. Dermatopathology (Basel) 2014; 1(1): 35–46. <> <PubMed>
58. Krengel S, Hauschild A, Schafer T. Melanoma risk in congenital melanocytic naevi: a systematic review. Br J Dermatol 2006; 155(1): 1–8. <>
59. Kubica A, Brewer J. Melanoma in immunosuppressed patients. Mayo Clin Proc 2012; 87(10): 991–1003. <> <PubMed>
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