Acta Med. 2019, 62: 150-155

https://doi.org/10.14712/18059694.2020.4

Genotype C/C 13910 of the Lactase Gene as a Risk Factor for the Formation of Insulin-Resistant Obesity in Children

Aleksandr Abaturov, Anna Nikulina

Department of Pediatrics and Medical Genetics, State Institution “Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine”, Dnipro, Ukraine

Received April 15, 2019
Accepted September 10, 2019

References

1. Levitt M, Wilt T, Shaukat A. Clinical implications of lactose malabsorption versus lactose intolerance. J Clin Gastroenterol 2013; 47(6): 471–80. <https://doi.org/10.1097/MCG.0b013e3182889f0f>
2. Lobstein T, Jackson‐Leach R. Planning for the worst: estimates of obesity and comorbidities in school‐age children in 2025. Pediatric Obesity 2016; 11(5): 321–5. <https://doi.org/10.1111/ijpo.12185>
3. Styne DM, Arslanian SA, Connor EL, et al. Pediatric Obesity-Assessment, Treatment, and Prevention: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2017; 102(3): 709–57. <https://doi.org/10.1210/jc.2017-00561> <PubMed>
4. Andrade MI, Oliveira JS, Leal VS, et al. Identification of cutoff points for Homeostatic Model Assessment for Insulin Resistance index in adolescents: systematic review. Rev Paul Pediatr. 2016; 4(2): 234–42. (In Portuguese). <https://doi.org/10.1016/j.rpped.2015.08.006>
5. Misselwitz B, Butter M, Verbeke K, et al. Update on lactose malabsorption and intolerance: pathogenesis, diagnosis and clinical management. Gut 2019; 68(11): 2080–91. <https://doi.org/10.1136/gutjnl-2019-318404> <PubMed>
6. Ahrens W, Moreno LA, Marild S, et al. IDEFICS consortium. Metabolic syndrome in young children: definitions and results of the IDEFICS study. Int J Obes (Lond) 2016; 38(2): 4–14. <https://doi.org/10.1038/ijo.2014.130>
7. Reinehr T. Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance. Curr Diab Rep 2016; 16(1): 8. <https://doi.org/10.1007/s11892-015-0695-1>
8. Chung ST, Onuzuruike AU, Magge SN. Cardiometabolic risk in obese children. Ann NY Acad Sci 2016; 1411: 166–83. <https://doi.org/10.1111/nyas.13602> <PubMed>
9. Vetter TR. Descriptive Statistics: Reporting the Answers to the 5 Basic Questions of Who, What, Why, When, Where, and a Sixth, So What? Anesth Analg 2017; 125(5): 1797–802. <https://doi.org/10.1213/ANE.0000000000002471>
10. Yang Y, Dong B, Zou Z, et al. Association between Vegetable Consumption and Blood Pressure, Stratified by BMI, among Chinese Adolescents Aged 13–17 Years: A National Cross-Sectional Study. Nutrients 2018, 10(4): E451. <https://doi.org/10.3390/nu10040451> <PubMed>
11. Paasela M, Kolho K-L, Vaarala О, Honkanen J. Lactose inhibits regulatory T-cell-mediated suppression of effector T-cell interferon-γ and IL-17 production. British Journal of Nutrients 2014; 112(11): 1819–25. <https://doi.org/10.1017/S0007114514001998> <PubMed>
12. Ostrowska L, Witczak K, Adamska E. Effect of nutrition and atherogenic index on the occurrence and intensity of insulin resistance. Pol Arch Med Wewn 2014; 123(6): 289–96.
13. Umer A, Kelley GA, Cottrell LE, et al. Childhood obesity and adult cardiovascular disease risk factors: a systematic review with meta-analysis. BMC Public Health 2017; 17(1): 683. <https://doi.org/10.1186/s12889-017-4691-z> <PubMed>
14. Vega-Carrascal I, Bergin DA, McElvaney OJ. Galectin-9 signaling through TIM-3 is involved in neutrophil-mediated Gram-negative bacterial killing: an effect abrogated within the cystic fibrosis lung. J Immunol 2014; 192(5): 2418–31. <https://doi.org/10.4049/jimmunol.1300711> <PubMed>
15. Abaturov AE, Nikulina AA, Logvinov DV, et al. (Dietotherapy in children with obesity associated with adult lactase deficiency). Zdorov’ye Rebenka 2017; 12(6): 657–62. (In Ukrainian).
16. Abaturov A, Stepanov Y, Nikulina A. Treatment of lactase deficiency in children’s obesity with genotype C/C 13910 of lactase gene. Wiad Lek 2019; 72(1): 17–21.
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive