Acta Med. 2019, 62: 99-104

Monocyte to Lymphocyte Ratio, Neutrophil to Lymphocyte Ratio, and Red Cell Distribution Width are the Associates with Gouty Arthritis

Cengiz Kadiyorana, Orhan Zenginb, Hilal Akay Cizmeciogluc, Abdurrahman Tufand, Orhan Kucuksahine, Medine Cumhur Curef, Erkan Cureg, Adem Kucukh, Mehmet Akif Ozturkd

aDepartment of Radiology, Necmettin Erbakan University, Konya, Turkey
bDepartment of Rheumatology, Adiyaman Training and Research Hospital, Adiyaman, Turkey
cDepartment of Internal Medicine, Necmettin Erbakan University, Konya, Turkey
dDivision of Rheumatology, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
eDivision of Rheumatology, Department of Internal Medicine, Ankara Liv Hospital, Kavaklidere, Ankara, Turkey
fDepartment of Biochemistry, Sadik Ahmet Hospital, Istanbul, Turkey
gDepartment of Internal Medicine, Ota&Jinemed Hospital, Istanbul, Turkey
hDivision of Rheumatology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey

Received April 4, 2019
Accepted July 18, 2019

Background: Neutrophils, monocytes, and macrophages activations are associated with a gout attack. Monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), red cell distribution width (RDW), and mean platelet volume (MPV) are well-known inflammation markers. In this study, we aimed to investigate whether they could be a predictive marker to the gout attack. Material and Methods: A hundred and ten gout patients (male/female, 86/24) and 90 (male/female, 64/26) age-, gender-, and body mass index-matched volunteer controls were included in the study. Blood samples were obtained in the intercritical and attack period of the patients. Hemogram, serum uric acid (SUA), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) values were studied. Results: In the attack period NLR (p < 0.001), PLR (p < 0.05), MLR (p < 0.001), RDW (p < 0.05), MPV (p < 0.05), ESR (p < 0.001), CRP (p < 0.001) and SUA (p < 0.001) values were significantly higher than intercritical period values. According to the results of regression analysis; There was an independent strong relationship between the gout attack and SUA, (Beta [β] = 0.352, p < 0.001), ESR (β = 0.329, p < 0.001), CRP (β = 0.286, p < 0.001), MLR (β = 0.126, p < 0.001), RDW (β = 0.100, p = 0.003) and NLR (β = 0.082, p = 0.014). Conclusions: MLR, RDW, and NLR may be a strong predictive marker for a gout attack. MPV and PLR values in the gout attack may be associated with systemic inflammation.


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