Acta Med. 2019, 62: 12-18

Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome

Ayca Tuzcua, Rabia Aydogan Baykarab, Murat Alışıkc, Ahmet Ommad, Gunseli Karaca Acetb, Erdal Doganb, Medine Cumhur Curee, Fatih Duygunf, Erkan Cureg, Ozcan Erelh

aDepartment of Biochemistry, Malatya Education and Research Hospital, Malatya, Turkey
bDepartment of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey
cDepartment of Clinical Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
dDivision of Rheumatology, Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey
eDepartment of Biochemistry, Istanbul Laboratory, Istanbul, Turkey
fDepartments of Orthopedics and Traumatology, Antalya Training and Research Hospital, Antalya, Turkey
gDepartment of Internal Medicine, Camlica Erdem Hastanesi, Istanbul, Turkey
hDepartment of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

Received March 22, 2018
Accepted November 12, 2018

Background: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. Material and methods: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel’s novel methods. Results: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. Conclusions: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.


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