Topiramate Reduces Aortic Cross-Clamping-Induced Lung Injury in Male Rats

Kurt, Aysel; Kalkan, Yildiray; Turut, Hasan; Cure, Medine Cumhur; Tumkaya, Levent; Cure, Erkan

doi:10.14712/18059694.2018.133

Acta Medica > Archive > 2018, Vol. 61 > Issue 4 > Topiramate Reduces Aortic…

Acta Med. 2018, 61: 144-149

https://doi.org/10.14712/18059694.2018.133

Topiramate Reduces Aortic Cross-Clamping-Induced Lung Injury in Male Rats

Aysel Kurt^a, Yildiray Kalkan^b, Hasan Turut^c, Medine Cumhur Cure^d, Levent Tumkaya^e, Erkan Cure^f

^aPrivate Practice, Department of Thoracic Surgery, Rize, Turkey
^bPrivate Practice, Department of Histology and Embryology, Rize, Turkey
^cRecep Tayyip Erdogan University, School of Medicine, Department of Thoracic Surgery, Rize, Turkey
^dIstanbul Laboratory, Department of Biochemistry, Istanbul, Turkey
^eRecep Tayyip Erdogan University, School of Medicine, Department of Histology and Embryology, Rize, Turkey
^fCamlica Erdem Hospital, Department of Internal Medicine, Istanbul, Turkey

Received February 10, 2018
Accepted November 2, 2018

Background: Topiramate (TPM) decreases cytokine release and generation of reactive oxygen species (ROS). Cytokine and endothelin-1 (ET-1) secretion and ROS formation play an important role in ischemia-reperfusion (I/R) injury. We aimed to evaluate whether TPM prevents damage occurring in lung tissue during I/R. Materials and Methods: A total of 27 Wistar albino rats were divided into three groups of nine. To the I/R group, two hours of ischemia via infrarenal abdominal aorta cross-ligation and then two hours of reperfusion process were applied. TPM (100 mg/kg/day) orally for seven days was administered in the TPM treatment group. After the last dose of TPM treatment, respectively, two hours of ischemia and two hours of reperfusion were applied in this group. Results: Tumor necrosis factor-alpha (TNF-α) (p < 0.05), malondialdehyde (MDA) (p < 0.05), myeloperoxidase (MPO) (p < 0.05) and ET-1 (p < 0.05) levels of TPM treatment group’s lung tissue were significantly lower than for the I/R group. Caspase-3 and histopathological damage were rather lower than that of the I/R group. Conclusions: During I/R, lung damage occurs due to excessive TNF-α and ET-1 release and ROS generation. TPM could well reduce development of lung damage by decreasing cytokine and ET-1 release and levels of ROS produced.