Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst

Jaafari-Ashkavandi, Zohreh; Tuyeh, Ahmad Alipour; Assar, Sepideh

doi:10.14712/18059694.2018.18

Acta Medica > Archive > 2018, Vol. 61 > Issue 1 > Immunohistochemical Expression of CDC7…

Acta Med. 2018, 61: 17-21

https://doi.org/10.14712/18059694.2018.18

Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst

Zohreh Jaafari-Ashkavandi^a, Ahmad Alipour Tuyeh^b, Sepideh Assar^c

^aDepartment of Oral & Maxillofacial Pathology, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
^bShiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran
^cDepartment of Oral & Maxillofacial Pathology, Hormozgan Dental School, Hormozgan University of Medical Sciences, Hormozgan, Bandar-Abbas, Iran

Received October 23, 2017
Accepted March 23, 2018

CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.