Acta Med. 2017, 60: 5-11
https://doi.org/10.14712/18059694.2017.44
Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy
Crossref Cited-by Linking
- Zhang Baoyue, Zhao Jun, Kang De, Wang Zhe, Xu Lvjie, Zheng RuiFang, Liu Ailin: Flubendazole suppresses VEGF‐induced angiogenesis in HUVECs and exerts antitumor effects in PC‐3 cells. Chem Biol Drug Des 2024, 103. <https://doi.org/10.1111/cbdd.14503>
- Xing Xing, Zhou Zongning, Peng Hongwei, Cheng Shaoping: Anticancer role of flubendazole: Effects and molecular mechanisms (Review). Oncol Lett 2024, 28. <https://doi.org/10.3892/ol.2024.14691>
- de Souza Gonçalves Débora, Yukuyama Megumi Nishitani, Miyagi Mariana Yasue Saito, Silva Tâmara Juliane Vieira, Lameu Claudiana, Bou-Chacra Nadia Araci, de Araujo Gabriel Lima Barros: Revisiting Flubendazole Through Nanocrystal Technology: Statistical Design, Characterization and Its Potential Inhibitory Effect on Xenografted Lung Tumor Progression in Mice. J Clust Sci 2023, 34, 261. <https://doi.org/10.1007/s10876-022-02220-x>
- Miyagi Mariana Yasue Saito, de Oliveira Faria Rafael, de Souza Gabriel Batista, Lameu Claudiana, Tagami Tatsuaki, Ozeki Tetsuya, Bezzon Vinícius Danilo Nonato, Yukuyama Megumi Nishitani, Bou-Chacra Nadia Araci, de Araujo Gabriel Lima Barros: Optimizing adjuvant inhaled chemotherapy: Synergistic enhancement in paclitaxel cytotoxicity by flubendazole nanocrystals in a cycle model approach. International Journal of Pharmaceutics 2023, 644, 123324. <https://doi.org/10.1016/j.ijpharm.2023.123324>
- Kim Jin, Bang Junpil, Ryu Bokyeong, Kim C-Yoon, Park Jae-Hak: Flubendazole exposure disrupts neural development and function of zebrafish embryos (Danio rerio). Science of The Total Environment 2023, 898, 165376. <https://doi.org/10.1016/j.scitotenv.2023.165376>
- Vítovcová Barbora, Skarková Veronika, Havelek Radim, Soukup Jiří, Pande Ananya, Caltová Kateřina, Rudolf Emil: Flubendazole exhibits anti-glioblastoma effect by inhibiting STAT3 and promoting cell cycle arrest. Sci Rep 2023, 13. <https://doi.org/10.1038/s41598-023-33047-9>
- Surov Artem O., Volkova Tatyana V.: Solubility/distribution thermodynamics and permeability of two anthelmintics in biologically relevant solvents. Journal of Molecular Liquids 2022, 354, 118835. <https://doi.org/10.1016/j.molliq.2022.118835>
- Song Bomi, Park Eun Young, Kim Kwang Joon, Ki Sung Hwan: Repurposing of Benzimidazole Anthelmintic Drugs as Cancer Therapeutics. Cancers 2022, 14, 4601. <https://doi.org/10.3390/cancers14194601>
- Weidong Lyu, Sanna Luca, Bordoni Valentina, Tiansheng Zeng, Chengxun Li, Murineddu Gabriele, Pinna Gerard A., Kelvin David J., Bagella Luigi: Target identification of a novel unsymmetrical 1,3,4‐oxadiazole derivative with antiproliferative properties. Journal Cellular Physiology 2021, 236, 3789. <https://doi.org/10.1002/jcp.30120>
- Alavi Seyed Ebrahim, Ebrahimi Shahmabadi Hasan: Anthelmintics for drug repurposing: Opportunities and challenges. Saudi Pharmaceutical Journal 2021, 29, 434. <https://doi.org/10.1016/j.jsps.2021.04.004>
- Zhou Xumin, Zou Libin, Chen Wenbin, Yang Taowei, Luo Junqi, Wu Kaihui, Shu Fangpeng, Tan Xiao, Yang Yu, Cen Shengren, Li Chuanyin, Mao Xiangming: Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer. Pharmacological Research 2021, 164, 105305. <https://doi.org/10.1016/j.phrs.2020.105305>
- Cortés Hernán, Reyes-Hernández Octavio D., Alcalá-Alcalá Sergio, Bernal-Chávez Sergio A., Caballero-Florán Isaac H., González-Torres Maykel, Sharifi-Rad Javad, González-Del Carmen Manuel, Figueroa-González Gabriela, Leyva-Gómez Gerardo: Repurposing of Drug Candidates for Treatment of Skin Cancer. Front. Oncol. 2021, 10. <https://doi.org/10.3389/fonc.2020.605714>
- Olivas-Aguirre Miguel, Torres-López Liliana, Pottosin Igor, Dobrovinskaya Oxana: Overcoming Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: Repurposed Drugs Can Improve the Protocol. Front. Oncol. 2021, 11. <https://doi.org/10.3389/fonc.2021.617937>
- Costa Ana, Vale Nuno: Strategies for the treatment of breast cancer: from classical drugs to mathematical models. MBE 2021, 18, 6328. <https://doi.org/10.3934/mbe.2021316>
- Nath Joyobrato, Paul Rajib, Ghosh Sankar Kumar, Paul Jaishree, Singha Baby, Debnath Nitu: Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects. Life Sciences 2020, 258, 118189. <https://doi.org/10.1016/j.lfs.2020.118189>
- Kortylewicz Zbigniew P., Coulter Don W., Baranowska-Kortylewicz Janina: Biological Evaluation of a Potential Anticancer Agent Methyl N-[5-(3′-Iodobenzoyl)-1H-Benzimidazol-2-yl]Carbamate. Cancer Biotherapy and Radiopharmaceuticals 2020, 35, 16. <https://doi.org/10.1089/cbr.2019.2988>
- Cortez-Maya Sandra, Moreno-Herrera Antonio, Palos Isidro, Rivera Gildardo: Old Antiprotozoal Drugs: Are They Still Viable Options for Parasitic Infections or New Options for Other Diseases?. CMC 2020, 27, 5403. <https://doi.org/10.2174/0929867326666190628163633>
- Barasa Leonard, Vemana Hari P., Surubhotla Nirupama, Ha Sin S., Kong Jing, Yong Alison, Croft John L., Dukhande Vikas V., Yoganathan Sabesan: Synthesis and Biological Evaluation of Structurally Diverse Benzimidazole Scaffolds as Potential Chemotherapeutic Agents. ACAMC 2020, 20, 301. <https://doi.org/10.2174/1871520619666191028101506>
- Armando Romina, Mengual G�mez Diego, Gomez Daniel: New drugs are not enough‑drug repositioning in oncology: An update. Int J Oncol 2020. <https://doi.org/10.3892/ijo.2020.4966>
- Son Deok-Soo, Lee Eun-Sook, Adunyah Samuel E.: The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw 2020, 20. <https://doi.org/10.4110/in.2020.20.e29>
- Yu Chen-Guang, Bondada Vimala, Ghoshal Sarbani, Singh Ranjana, Pistilli Christina K., Dayaram Kavi, Iqbal Hina, Sands Madison, Davis Kate, Bondada Subbarao, Geddes James W.: Repositioning Flubendazole for Spinal Cord Injury. Journal of Neurotrauma 2019. <https://doi.org/10.1089/neu.2018.6160>
- Awad Dominik, Prattes Michael, Kofler Lisa, Rössler Ingrid, Loibl Mathias, Pertl Melanie, Zisser Gertrude, Wolinski Heimo, Pertschy Brigitte, Bergler Helmut: Inhibiting eukaryotic ribosome biogenesis. BMC Biol 2019, 17. <https://doi.org/10.1186/s12915-019-0664-2>
- Lin Shichong, Yang Lehe, Yao Yulei, Xu Lingyuan, Xiang Youqun, Zhao Haiyang, Wang Liangxing, Zuo Zhigui, Huang Xiaoying, Zhao Chengguang: Flubendazole demonstrates valid antitumor effects by inhibiting STAT3 and activating autophagy. J Exp Clin Cancer Res 2019, 38. <https://doi.org/10.1186/s13046-019-1303-z>
- Levkut M., Revajová V., Levkutová M., Selecká E., Ševčíková Z., Karaffová V., Levkut M.: The influence of chestnut wood and flubendazole on morphology of small intestine and lymphocytes of peripheral blood, spleen and jejunum in broiler chickens. Helminthologia 2019, 56, 273. <https://doi.org/10.2478/helm-2019-0029>
- Gouveia Maria João, Brindley Paul J., Rinaldi Gabriel, Gärtner Fátima, da Costa José Manuel Correia, Vale Nuno: Combination Anthelmintic/Antioxidant Activity Against Schistosoma Mansoni. Biomolecules 2019, 9, 54. <https://doi.org/10.3390/biom9020054>
- Oh Eunhye, Kim Yoon‐Jae, An Hyunsook, Sung Daeil, Cho Tae‐Min, Farrand Lee, Jang Seojin, Seo Jae Hong, Kim Ji Young: Flubendazole elicits anti‐metastatic effects in triple‐negative breast cancer via STAT3 inhibition. Intl Journal of Cancer 2018, 143, 1978. <https://doi.org/10.1002/ijc.31585>
- Čáňová K., Rozkydalová L., Vokurková D., Rudolf E.: Flubendazole induces mitotic catastrophe and apoptosis in melanoma cells. Toxicology in Vitro 2018, 46, 313. <https://doi.org/10.1016/j.tiv.2017.10.025>