Acta Med. 2017, 60: 12-18

https://doi.org/10.14712/18059694.2017.43

The Osteogenic Potential of Human Nondifferentiated and Pre-differentiated Mesenchymal Stem Cells Combined with an Osteoconductive Scaffold – Early Stage Healing

Luboš Tučeka, Zuzana Kočíb,c,d, Kristýna Károvác,d, Helena Doležalováa, Jakub Sucháneka

aDepartment of Dentistry, Charles University, Medical Faculty and University Hospital Hradec Králové, Czech Republic
bBioinova, Ltd, Prague, Czech Republic
cDepartment of Neuroscience, 2nd Faculty of Medicine, Charles University, Czech Republic
dInstitute of Experimental Medicine ASCR, Prague, Czech Republic

Received November 25, 2016
Accepted December 20, 2016

References

1. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 2012; 40: 363–408. <https://doi.org/10.1615/CritRevBiomedEng.v40.i5.10>
2. Amini AR, Laurencin CT, Nukavarapu SP. Differential analysis of peripheral blood‐ and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering. J Orthop Res 2012; 30: 1507–1515. <https://doi.org/10.1002/jor.22097>
3. Baroli B. From natural bone grafts to tissue engineering therapeutics: brainstorming on pharmaceutical formulative requirements and challenges. J Pharm Sci 2009; 98: 1317–1375. <https://doi.org/10.1002/jps.21528>
4. Buschmann J, Welti M, Hemmi S, Neuenschwander P, Baltes C, Giovanoli P, Rudin M, Calcagni M. Three-dimensional co-cultures of osteoblasts and endothelial cells in DegraPol foam: histological and high-field magnetic resonance imaging analyses of pre-engineered capillary networks in bone grafts. Tissue Eng Pt A 2010; 17: 291–299. <https://doi.org/10.1089/ten.tea.2010.0278>
5. Dimitriou R, Jones E, McGonagle D, Giannoudis PV. Bone regeneration: current concepts and future directions. BMC Med 2011; 9: 66. <https://doi.org/10.1186/1741-7015-9-66> <PubMed>
6. Fedorovich NE, Haverslag RT, Dhert WJ, Alblas J. The role of endothelial progenitor cells in prevascularized bone tissue engineering: development of heterogeneous constructs. Tissue Eng Pt A 2010; 16: 2355–2367. <https://doi.org/10.1089/ten.tea.2009.0603>
7. Gazdag AR, Lane JM, Glaser D, Forster RA. Alternatives to autogenous bone graft: efficacy and indications. J Am Acad Orthop Sur 1995; 3: 1–8. <https://doi.org/10.5435/00124635-199501000-00001>
8. Gronthos S, Chen S, Wang CY, Robey PG, Shi S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res 2003; 18: 716–22. <https://doi.org/10.1359/jbmr.2003.18.4.716>
9. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials 2005; 26: 5474–5491. <https://doi.org/10.1016/j.biomaterials.2005.02.002>
10. Rosset P, Deschaseaux F, Layrolle P. Cell therapy for bone repair. Orthop Traumatol Surg Res 2014; 100: 107–112. <https://doi.org/10.1016/j.otsr.2013.11.010>
11. Shimizu K, Ito A, Yoshida T, Yamada Y, Ueda M, Honda H. Bone tissue engineering with human mesenchymal stem cell sheets constructed using magnetite nanoparticles and magnetic force. J Biomed Mater Res B 2007; 82: 471–480. <https://doi.org/10.1002/jbm.b.30752>
12. Schliephake H, Knebel JW, Aufderheide M, Tauscher M. Use of cultivated osteoprogenitor cells to increase bone formation in segmental mandibular defects: an experimental pilot study in sheep. Int J Oral Max Surg 2001; 30: 531–537. <https://doi.org/10.1054/ijom.2001.0164>
13. Soucacos PN, Johnson EO, Babis G. An update on recent advances in bone regeneration. Injury 2008; 39: 1–4. <https://doi.org/10.1016/j.injury.2008.05.013>
14. Zisch AH, Lutolf MP, Hubbell JA. Biopolymeric delivery matrices for angiogenic growth factors. Cardiovasc Pathol 2003; 12: 295–310. <https://doi.org/10.1016/S1054-8807(03)00089-9>
15. Zhou G, Liu W, Cui L, Wang X, Liu T, Cao Y. Repair of porcine articular osteochondral defects in non-weightbearing areas with autologous bone marrow stromal cells. Tissue Eng 2006; 12: 3209–3221. <https://doi.org/10.1089/ten.2006.12.3209>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive