A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma

Sousa, Nathália Vieira; Marques de Oliveira, Luísa Coelho; Cortez, Paulo José Oliveira; Valenti, Vitor Engrácia; Garner, David Mathew; Irulegui, Roseane de Souza Candido; Moreira, Dalmo Antônio Ribeiro

doi:10.14712/18059694.2016.92

Acta Medica > Archive > 2016, Vol. 59 > Issue 2 > A rare case of Ganglioneuroblastoma…

Acta Med. 2016, 59: 67-69

https://doi.org/10.14712/18059694.2016.92

A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma

Nathália Vieira Sousa^a, Luísa Coelho Marques de Oliveira^a, Paulo José Oliveira Cortez^a, Vitor Engrácia Valenti^b, David Mathew Garner^c, Roseane de Souza Candido Irulegui^a, Dalmo Antônio Ribeiro Moreira^a,d

^aFaculdade de Medicina de Itajubá, Av. Renó Júnior, 368 – São Vicente, Itajubá, MG, Brazil
^bPrograma de Pós-Graduação em Fisioterapia, Faculdade de Ciências e Tecnologia, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, Brazil
^cDepartment of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, United Kingdom
^dInstituto Dante Pazzanese de Cardiologia, Av. Dr. Dante Pazzanese, 500, São Paulo, SP, Brazil

Received October 16, 2015
Accepted March 2, 2016

Pheochromocytoma and Ganglioneuroblastoma are separate diseases and a rare combination in which the diagnosis can only be confirmed by pathological examination after tumor excision. We reported here a case of ganglioneuroblastoma encapsulated in pheochromocytoma. The patient is a woman, 73 years old, hypertensive, with hypothyroidism, associated for 15 years with hypercholesterolemia and hypertriglyceridemia, which had frequent complaints of low back pain. She underwent magnetic resonance and the findings were consistent with the diagnosis of pheochromocytoma. After surgery, anatomic, pathologic and immunohistochemistry analysis confirmed the diagnosis of pheochromocytoma composed by small ganglioneuroblastoma representation with the identification of small focus of infiltration of the adrenal capsule and adipose tissue by pheochromocytoma. This rare association can instigate the discussion of methods of diagnosis, more effective and more appropriate treatments for each patient.