Acta Med. 2015, 58: 131-134

Oesophageal Manometry in Experimental Pigs: Methods and Initial Experience

Ilja Tachecía, Věra Radochováb, Jaroslav Květinaa,c, Stanislav Rejchrta, Marcela Kopáčováa, Jan Bureša

a2nd Department of Internal Medicine – Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Hospital Hradec Králové, Czech Republic
bAnimal Laboratory, University of Defence, Faculty of Military Health Sciences, Hradec Králové, Czech Republic
cInstitute of Experimental Biopharmaceutics, Czech Academy of Sciences, Hradec Králové, Czech Republic

Received October 25, 2015
Accepted November 24, 2015

The aim of this study project was to prepare our own method of porcine oesophageal manometry. Ten mature experimental pigs entered the study. Conventional water-perfused system was decided for manometry. Porcine resting and relaxed pressures of the lower oesophageal sphincter are fully comparable with healthy human subjects. Evocable swallowing is doable and oesophageal peristalsis is quantifiable. Basic manometric parameters were different in male and female animals. Oesophageal manometry in experimental pigs is feasible. Porcine oesophageal manometry will be usable for preclinical studies in future.


The study was supported by an independent research grant NT/14270 from the Ministry of Health, Czech Republic.


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