Oesophageal Manometry in Experimental Pigs: Methods and Initial Experience

Tachecí, Ilja; Radochová, Věra; Květina, Jaroslav; Rejchrt, Stanislav; Kopáčová, Marcela; Bureš, Jan

doi:10.14712/18059694.2016.5

Acta Medica > Archive > 2015, Vol. 58 > Issue 4 > Oesophageal Manometry in Experimental…

Acta Med. 2015, 58: 131-134

https://doi.org/10.14712/18059694.2016.5

Oesophageal Manometry in Experimental Pigs: Methods and Initial Experience

Ilja Tachecí^a, Věra Radochová^b, Jaroslav Květina^a,c, Stanislav Rejchrt^a, Marcela Kopáčová^a, Jan Bureš^a

^a2nd Department of Internal Medicine – Gastroenterology, Charles University in Praha, Faculty of Medicine at Hradec Králové, University Hospital Hradec Králové, Czech Republic
^bAnimal Laboratory, University of Defence, Faculty of Military Health Sciences, Hradec Králové, Czech Republic
^cInstitute of Experimental Biopharmaceutics, Czech Academy of Sciences, Hradec Králové, Czech Republic

Received October 25, 2015
Accepted November 24, 2015

The aim of this study project was to prepare our own method of porcine oesophageal manometry. Ten mature experimental pigs entered the study. Conventional water-perfused system was decided for manometry. Porcine resting and relaxed pressures of the lower oesophageal sphincter are fully comparable with healthy human subjects. Evocable swallowing is doable and oesophageal peristalsis is quantifiable. Basic manometric parameters were different in male and female animals. Oesophageal manometry in experimental pigs is feasible. Porcine oesophageal manometry will be usable for preclinical studies in future.