Acta Med. 2015, 58: 56-61

https://doi.org/10.14712/18059694.2015.94

Pistacia Terebinthus Coffee Protects against Thioacetamide-Induced Liver Injury in Rats

Ibrahim Halil Bahçecıoğlua, Murat Ispiroglua, Mehmet Tuzcub, Cemal Orhanc, Mustafa Ulasd, Ulvi Demirela, Mehmet Yalniza, Ibrahim H. Özercane, Necip Ilhanf, Kazim Sahinc

aDepartment of Gastroenterology, Firat University Faculty of Medicine, Elazig, Turkey
bDepartment of Biology, Firat University Faculty of Medicine, Elazig, Turkey
cDepartment of Animal Nutrition, Firat University Faculty of Medicine, Elazig, Turkey
dDepartment of Physiology, Firat University Faculty of Medicine, Elazig, Turkey
eDepartment of Pathology, Firat University Faculty of Medicine, Elazig, Turkey
fDepartment of Biochemistry, Firat University Faculty of Medicine, Elazig, Turkey

Received July 27, 2014
Accepted May 28, 2015

Aim/background: Pistacia terebinthus is used as a coffee substitute in the East and Southern Anatolia regions of Turkey. It contains unsaturated fatty acids, tocopherols, polyphenols and carotenoids. P. terebinthus has anti-inflammatory and potential antioxidant activity. In this study we evaluated the protective effects of P. terebinthus coffee (PTC) on thioacetamide (TAA)-induced liver injury in rats. Materials and methods: Twenty-eight male Sprague-Dawley rats were equally randomized into four groups. Chronic liver injury was induced with TAA (100 mg/kg i.p. three times weekly). The first group of rats served as control and received only tap water (G1), and the remaining groups of rats received PTC, p.o (G2); TAA (G3); TAA plus PTC, p.o (G4), respectively. Results: After 8 weeks, PTC intake significantly reduced fibrosis/inflammation scores (p < 0.05) in the livers of TAA-treated group. Compared to control group, PTC intake reduced transforming growth factor beta (TGF-β) concentrations in the liver (p < 0.05). Compared to the TAA group, TGF-β, nuclear factor kappa B (NF)-κB (p < 0.05), tumor necrosis factor alpha (TNF-α) concentrations in the liver tissue were reduced by PTC intake. Discussion and conclusion: PTC intake provided beneficial effects against TAA-induced liver injury in rats. PTC probably suppresses the proinflammatory cytokines through NF-κB signaling pathway.

References

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