Acta Med. 2014, 57: 97-104

Familial Mediterranean Fever

Adem Kucuka, Ilknur Albayrak Gezerb, Ramazan Ucarc, Ali Yavuz Karahand

aNecmettin Erbakan Üniversitesi Romatoloji Bilim Dalı Konya,Turkey
bEğitim ve Araştırma Hastanesi Fiziksel Tıp ve Rehabilitasyon Bölümü Konya, Turkey
cKonya Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği, Konya, Turkey
dDevlet Hastanesi Fiziksel Tıp ve Rehabilitasyon Bölümü Konya, Turkey

Received April 19, 2014
Accepted June 20, 2014

Familial Mediterranean Fever is an autosomal recessive inherited disease with a course of autoinflammation, which is characterized by the episodes of fever and serositis. It affects the populations from Mediterranean basin. Genetic mutation of the disease is on MEFV gene located on short arm of Chromosome 16. The disease is diagnosed based on clinical evaluation. Amyloidosis is the most important complication. The only agent that decreases the development of amyloidosis and the frequency and severity of the episodes is colchicine, which has been used for about 40 years. In this review, we aimed to discuss especially the most recent advances about Familial Mediterranean Fever which is commonly seen in our population.


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