Recalcitrant Pruritus as Primary Manifestation of Synchronous Hodgkins Lymphoma and Langerhans Cell Histiocytosis

Topal, Afsha A.; Malkani, Ram H.; Bhat, Ganapathi; Vishnani, Reshma T.

doi:10.14712/18059694.2015.65

Acta Medica > Archive > 2012, Vol. 55 > Issue 2 > Recalcitrant Pruritus as Primary…

Acta Med. 2012, 55: 104-106

https://doi.org/10.14712/18059694.2015.65

Recalcitrant Pruritus as Primary Manifestation of Synchronous Hodgkins Lymphoma and Langerhans Cell Histiocytosis

Afsha A. Topal^a, Ram H. Malkani^a, Ganapathi Bhat^b, Reshma T. Vishnani^a

^aDepartment of Dermatology, Jaslok Hospital and Research Centre, Mumbai, India
^bDepartment of Oncology, Jaslok Hospital and Research Centre, Mumbai, India

Received January 16, 2012
Accepted June 9, 2012

We present a 73 year old female with intractable pruritus and nonspecific cutaneous rash for a period of 9 months. She had recieved symptomatic therapy with no improvement. A complete examination revealed axillary and abdominal lymphadenopathy. A biopsy confirmed the diagnosis of Hodgkins lymphoma with Langerhans cell histiocytosis. She received 5 cycles of chemotherapy with resolution of pruritus and reduction in axillary and abdominal lymphadenopathy. The patient presented 6 months later with relapse and succumbed to the illness. Simultaneous occurrence of Langerhans cell histiocytosis and Hodgkins lymphoma may lead to misdiagnosis. The awareness of such an association is important to make an accurate diagnosis and guide appropriate therapy.