Preoperative Serum Levels of Soluble Endoglin for Prediction of Recurrence in Stage III Colorectal Cancer Patients

Gomceli, Ismail; Tez, Mesut; Bostanci, Erdal B.; Turhan, Nesrin; Kemik, Ahu S.; Akoglu, Musa

doi:10.14712/18059694.2015.58

Acta Medica > Archive > 2012, Vol. 55 > Issue 2 > Preoperative Serum Levels of Soluble…

Acta Med. 2012, 55: 74-77

https://doi.org/10.14712/18059694.2015.58

Preoperative Serum Levels of Soluble Endoglin for Prediction of Recurrence in Stage III Colorectal Cancer Patients

Ismail Gomceli^a, Mesut Tez^b, Erdal B. Bostanci^a, Nesrin Turhan^c, Ahu S. Kemik^d, Musa Akoglu^a

^aTurkiye Yuksek Ihtisas Education and Research Hospital, Department of Gastroenterologic Surgery, Ankara, Turkey
^bAnkara Numune Education and Research Hospital, Department of General Surgery, Ankara, Turkey
^cTurkiye Yuksek Ihtisas Education and Research Hospital Department of Pathology, Ankara, Turkey
^dIstanbul University Cerrahpasa Medical Faculty, Department of Biochemistry, Istanbul, Turkey

Received October 20, 2011
Accepted May 9, 2012

Background: To evaluate the clinical usefulness of serum levels of soluble form of endoglin in stage III colorectal adenocarcinomas (CRC) patients for detection of recurrence. Methods: The case-control study consisted of 80 stage III CRC patients who underwent surgery with curative intent and 70 age-and sex-matched healthy volunteers. Serum levels of soluble form of endoglin (sol-end) were measured in both groups. Also, predictive factors of recurrence were evaluated using multivariate analyses. Results: Serum levels of sol-end in stage III CRC patients were significantly higher than those in controls. There was not a significant association between serum levels of sol-end and clinicopathological features in CRC patients. Multivariate regression analysis showed the LNR (hazard ratio, 2.54; 95% CI, 1.46–4.34; p < 0.001), to be significant independent factors to estimate local recurrence in stage III CRC patients. Conclusion: Preoperative serum levels of sol-end do not seem useful as a marker for detection of recurrence in stage III CRC patients.