Acta Med. 2012, 55: 12-17

https://doi.org/10.14712/18059694.2015.68

CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; part I: CD200/CD200R Structure, Activation, and Function

Drahomíra Holmannováa, Martina Koláčkováa, Kateřina Kondělkováa, Pavel Kunešb, Jan Krejseka, Ctirad Andrýsa

aCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Clinical Immunology and Allergology
bCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic: Department of Cardiac Surgery

Received August 16, 2011
Accepted March 20, 2012

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  • Kanannejad Zahra, Soleimanian Saeede, Ghahramani Zahra, Sepahi Najmeh, Mohkam Milad, Alyasin Soheila, Kheshtchin Nasim: Immune checkpoint molecules in prevention and development of asthma. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1070779>
  • Patoine Dany, Bouchard Karine, Lemay Anne-Marie, Bissonnette Elyse Y., Lauzon-Joset Jean-Francois: Specificity of CD200/CD200R pathway in LPS-induced lung inflammation. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.1092126>
  • Abramiuk Monika, Grywalska Ewelina, Małkowska Paulina, Sierawska Olga, Hrynkiewicz Rafał, Niedźwiedzka-Rystwej Paulina: The Role of the Immune System in the Development of Endometriosis. Cells 2022, 11, 2028. <https://doi.org/10.3390/cells11132028>
  • Ampudia-Mesias Elisabet, Puerta-Martinez Francisco, Bridges Miurel, Zellmer David, Janeiro Andrew, Strokes Matt, Sham Yuk Y., Taher Ayman, Castro Maria G., Moertel Christopher L., Pluhar G. Elizabeth, Olin Michael R.: CD200 Immune-Checkpoint Peptide Elicits an Anti-glioma Response Through the DAP10 Signaling Pathway. Neurotherapeutics 2021, 18, 1980. <https://doi.org/10.1007/s13311-021-01038-1>
  • Van Broeckhoven Jana, Sommer Daniela, Dooley Dearbhaile, Hendrix Sven, Franssen Aimée J P M: Macrophage phagocytosis after spinal cord injury: when friends become foes. Brain 2021, 144, 2933. <https://doi.org/10.1093/brain/awab250>
  • Haunerdinger Veronika, Moccia Maria Domenica, Opitz Lennart, Vavassori Stefano, Dave Hitendu, Hauri-Hohl Mathias M.: Novel Combination of Surface Markers for the Reliable and Comprehensive Identification of Human Thymic Epithelial Cells by Flow Cytometry: Quantitation and Transcriptional Characterization of Thymic Stroma in a Pediatric Cohort. Front. Immunol. 2021, 12. <https://doi.org/10.3389/fimmu.2021.740047>
  • La Torre Maria Ester, Villano Ines, Monda Marcellino, Messina Antonietta, Cibelli Giuseppe, Valenzano Anna, Pisanelli Daniela, Panaro Maria Antonietta, Tartaglia Nicola, Ambrosi Antonio, Carotenuto Marco, Monda Vincenzo, Messina Giovanni, Porro Chiara: Role of Vitamin E and the Orexin System in Neuroprotection. Brain Sciences 2021, 11, 1098. <https://doi.org/10.3390/brainsci11081098>
  • Li Dongping, Wang Ying, Tang Lu, Jin Xinrong, Xia Chunlei, Xu Hanmei, Hu Jialiang: CD200-CD200R1 signalling attenuates imiquimod-induced psoriatic inflammation by inhibiting the activation of skin inflammatory macrophages. International Immunopharmacology 2020, 78, 106046. <https://doi.org/10.1016/j.intimp.2019.106046>
  • Mucha Sören, Baurecht Hansjörg, Novak Natalija, Rodríguez Elke, Bej Saptarshi, Mayr Gabriele, Emmert Hila, Stölzl Dora, Gerdes Sascha, Jung Eun Suk, Degenhardt Frauke, Hübenthal Matthias, Ellinghaus Eva, Kässens Jan Christian, Wienbrandt Lars, Lieb Wolfgang, Müller-Nurasyid Martina, Hotze Melanie, Dand Nick, Grosche Sarah, Marenholz Ingo, Arnold Andreas, Homuth Georg, Schmidt Carsten O., Wehkamp Ulrike, Nöthen Markus M., Hoffmann Per, Paternoster Lavinia, Standl Marie, Bønnelykke Klaus, Ahluwalia Tarunveer S., Bisgaard Hans, Peters Annette, Gieger Christian, Waldenberger Melanie, Schulz Holger, Strauch Konstantin, Werfel Thomas, Lee Young-Ae, Wolfien Markus, Rosenstiel Philip, Wolkenhauer Olaf, Schreiber Stefan, Franke Andre, Weidinger Stephan, Ellinghaus David: Protein-coding variants contribute to the risk of atopic dermatitis and skin-specific gene expression. Journal of Allergy and Clinical Immunology 2020, 145, 1208. <https://doi.org/10.1016/j.jaci.2019.10.030>
  • Liu Ting‐Ting, Zeng Xiang‐Peng, Gu Ming‐Li, Deng An‐Mei: Increased CD200 levels in peripheral blood mononuclear cells of patients with primary Sjögren's syndrome. Int J of Rheum Dis 2020, 23, 654. <https://doi.org/10.1111/1756-185X.13810>
  • Ismail Aisha A., Donia Hanaa M., Ghatesh Hafsa M., Farid Carmen I., Zirlik Andreas: CD200/CD200 receptor axis in psoriasis vulgaris. PLoS ONE 2020, 15, e0230621. <https://doi.org/10.1371/journal.pone.0230621>
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  • Hu Yaguang, Wei Ting, Gao Shan, Cheng Qiaochu: Anti-angiogenic and anti-inflammatory effects of CD200–CD200R1 axis in oxygen-induced retinopathy mice model. Inflamm. Res. 2019, 68, 945. <https://doi.org/10.1007/s00011-019-01276-2>
  • Hu Yaguang, Xie Anming, Cheng Qiaochu: Upregulated CD200 in pre-retinal proliferative fibrovascular membranes of proliferative diabetic retinopathy patients and its correlation with vascular endothelial growth factor. Inflamm. Res. 2019, 68, 1071. <https://doi.org/10.1007/s00011-019-01290-4>
  • Lauzon-Joset Jean-François, Marsolais David, Tardif-Pellerin Éliane, Patoine Dany, Bissonnette Elyse Y.: CD200 in asthma. The International Journal of Biochemistry & Cell Biology 2019, 112, 141. <https://doi.org/10.1016/j.biocel.2019.05.003>
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  • Mahadevan Daruka, Lanasa Mark C., Farber Charles, Pandey Manjari, Whelden Maria, Faas Susan J., Ulery Terrie, Kukreja Anjli, Li Lan, Bedrosian Camille L., Zhang Xiaoping, Heffner Leonard T.: Phase I study of samalizumab in chronic lymphocytic leukemia and multiple myeloma: blockade of the immune checkpoint CD200. j. immunotherapy cancer 2019, 7. <https://doi.org/10.1186/s40425-019-0710-1>
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  • Xu Jie, Gu Yang, Sun Jingxia, Zhu Hui, Lewis David F., Wang Yuping: Reduced CD200 expression is associated with altered Th1/Th2 cytokine production in placental trophoblasts from preeclampsia. American J Rep Immunol 2018, 79. <https://doi.org/10.1111/aji.12763>
  • Arefieva A. S., Babayan A. A., Stepanova E. O., Dontsova T. V., Pavlovich S. V., Krechetova L. V., Nikolaeva M. A.: THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY. Med. immunol. 2018, 20, 807. <https://doi.org/10.15789/1563-0625-2018-6-807-814>
  • Morgan David J., Casulli Joshua, Chew Christine, Connolly Emma, Lui Sylvia, Brand Oliver J., Rahman Rizwana, Jagger Christopher, Hussell Tracy: Innate Immune Cell Suppression and the Link With Secondary Lung Bacterial Pneumonia. Front. Immunol. 2018, 9. <https://doi.org/10.3389/fimmu.2018.02943>
  • Hassani Seyedeh Nafiseh, Rezaeeyan Hadi, Ghodsi Asma, Saki Najmaldin: Restoration of natural killer cell cytotoxicity in the suppressive tumor microenvironment: novel approaches to treat AML. J Hematopathol 2017, 10, 109. <https://doi.org/10.1007/s12308-017-0306-y>
  • Wein Frederik, Weniger Marc A., Höing Benedikt, Arnolds Judith, Hüttmann Andreas, Hansmann Martin-Leo, Hartmann Sylvia, Küppers Ralf: Complex Immune Evasion Strategies in Classical Hodgkin Lymphoma. Cancer Immunology Research 2017, 5, 1122. <https://doi.org/10.1158/2326-6066.CIR-17-0325>
  • Ma Xinhua, Chen Shisheng, Jin Wanwan, Gao Yu: Th1/Th2 PB balance and CD200 expression of patients with active severe alopecia areata. Experimental and Therapeutic Medicine 2017, 13, 2883. <https://doi.org/10.3892/etm.2017.4312>
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  • Sun Haoyu, Xu Jing, Huang Mei, Huang Qiang, Sun Rui, Xiao Weihua, Sun Cheng: CD200R, a co-inhibitory receptor on immune cells, predicts the prognosis of human hepatocellular carcinoma. Immunology Letters 2016, 178, 105. <https://doi.org/10.1016/j.imlet.2016.08.009>
  • Pan Z-J, Horton C G, Lawrence C, Farris A D: Plasmacytoid dendritic cells and type 1 interferon promote peripheral expansion of forkhead box protein 3+ regulatory T cells specific for the ubiquitous RNA-binding nuclear antigen La/Sjögren's syndrome (SS)-B. Clinical and Experimental Immunology 2016, 186, 18. <https://doi.org/10.1111/cei.12817>
  • Thompson Heather L., van Rooijen Nico, McLelland Bryce T., Manilay Jennifer O.: F4/80+ Host Macrophages Are a Barrier to Murine Embryonic Stem Cell-Derived Hematopoietic Progenitor Engraftment In Vivo. Journal of Immunology Research 2016, 2016, 1. <https://doi.org/10.1155/2016/2414906>
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  • Olde Nordkamp Marloes J.M., Koeleman Bobby P., Meyaard Linde: Do inhibitory immune receptors play a role in the etiology of autoimmune disease?. Clinical Immunology 2014, 150, 31. <https://doi.org/10.1016/j.clim.2013.11.007>
  • Moertel Christopher L, Xia Junzhe, LaRue Rebecca, Waldron Nate N, Andersen Brian M, Prins Robert M, Okada Hideho, Donson Andrew M, Foreman Nicholas K, Hunt Matthew A, Pennell Christopher A, Olin Michael R: CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy. j. immunotherapy cancer 2014, 2. <https://doi.org/10.1186/s40425-014-0046-9>
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  • Osman AmanyA, Eissa DoaaG, Moussa MohamedM: CD200 is an independent prognostic factor in multiple myeloma. Egypt J Haematol 2014, 39, 177. <https://doi.org/10.4103/1110-1067.148254>
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  • Alpsoy Erkan: There might be a role for CD200 in the pathogenesis of autoimmune and inflammatory skin disorders. Med Sci Monit 2013, 19, 888. <https://doi.org/10.12659/MSM.889624>
  • Walker Douglas G, Lue Lih-Fen: Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?. Future Neurology 2013, 8, 321. <https://doi.org/10.2217/fnl.13.14>
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