Acta Med. 2012, 55: 27-31

https://doi.org/10.14712/18059694.2015.71

The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice

Jiří Kassaa, Jana Zdarová Karasováb, Růžena Pavlíkováa, Filip Caisbergera,c, Jiří Bajgara

aUniversity of Defence, Faculty of Military Health Sciences, Hradec Králové, Czech Republic: Department of Toxicology
bUniversity of Defence, Faculty of Military Health Sciences, Hradec Králové, Czech Republic: Department of Public Health
cCharles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic: Department of Anatomy

Received August 25, 2011
Accepted December 5, 2011

References

1. Bajgar J. Organophosphate/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv Clin Chem 2004; 38: 151–216. <https://doi.org/10.1016/S0065-2423(04)38006-6>
2. Bajgar J. Complex view on poisoning with nerve agents and organophosphates. Acta Med (Hradec Kralove) 2005; 48: 3–21. <https://doi.org/10.14712/18059694.2018.23>
3. Clement JG, Hansen AS, Boulet CA. Efficacy of HLö‑7 and pyrimidoxime as antidotes of nerve agent poisoning in mice. Arch Toxicol 1992; 66: 216–9. <https://doi.org/10.1007/BF01974018>
4. Clement JG, Shiloff JD, Gennings Ch. Efficacy of a combination of acetylcholinesterase reactivators, HI‑6 and obidoxime, against tabun and soman poisoning of mice. Arch Toxicol 1987; 61: 70–5. <https://doi.org/10.1007/BF00324551>
5. Dawson RM. Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 1994; 14: 317–31. <https://doi.org/10.1002/jat.2550140502>
6. Ellman GL, Courtney DK, Andres VJr, Feartherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961; 7: 88–93. <https://doi.org/10.1016/0006-2952(61)90145-9>
7. Herkert NM, Lallement G, Clarencon D, Thiermann H, Worek F. Comparison of the oxime‑induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real‑time determination of membrane‑bound acetylcholinesterase activity. Toxicology 2009; 258: 79–83. <https://doi.org/10.1016/j.tox.2009.01.014>
8. Jeong HCH, Park NJ, Chae CHH et al. Fluorinated pyridinium oximes as potential reactivators for acetylcholinesterases inhibited by paraoxon organophosphorus agent. Bioorg Med Chem 2009; 17: 6213–7. <https://doi.org/10.1016/j.bmc.2009.07.043>
9. Jokanovic M, Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure‑activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr Med Chem 2009; 16: 2177–88. <https://doi.org/10.2174/092986709788612729>
10. Jun D, Kuca K, Stodulka P et al. HPLC analysis of HI‑6 dichloride and dimethansulfonate – antidotes against nerve agents and organophosphorus pesticides. Anal Lett 2007; 40: 2783–7. <https://doi.org/10.1080/00032710701588531>
11. Kassa J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002; 40: 803–16. <https://doi.org/10.1081/CLT-120015840>
12. Kassa J, Karasova J, Musilek K, Kuca K. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI‑6) in tabun‑poisoned rats and mice. Toxicology 2008; 243: 311–6. <https://doi.org/10.1016/j.tox.2007.10.015>
13. Kassa J, Kuca K, Bartosova L, Kunesova G. The development of new structural analogues of oximes for the antidotal treatment of poisoning by nerve agents and the comparison of their reactivating and therapeutic efficacy with currently available oximes. Curr Org Chem 2007; 11: 267–83. <https://doi.org/10.2174/138527207779940874>
14. Kassa J, Zdarova Karasova J, Caisberger F, Bajgar J. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of soman poisoning in rats and mice. Toxicol Mech Method 2009; 19: 547–51. <https://doi.org/10.3109/15376510903350371>
15. Kassa J, Zdarova Karasova J, Pavlikova R, Misik J, Caisberger F, Bajgar J. The influence of combinations of oximes on the reactivating and therapeutic efficacy of antidotal treatment of tabun poisoning in rats and mice. J Appl Toxicol 2010; 30: 120–4.
16. Kovacevic V, Maksimovic M, Deljac V, Binenfeld Z. Protective effects of mixture of oximes in poisoning by nerve chemical warfare agents. Acta Pharm Jugoslav 1991; 41: 75–8.
17. Kovacevic V, Maksimovic M, Pantelic D, Vojvodic V, Binenfeld Z. Protective and reactivating effects of HI‑6 + PA M‑2 mixture in rats poisoned with nerve chemical warfare agents. Acta Pharm Jugoslav 1989; 39: 161–5.
18. Kovarik Z, Calic M, Sinko G et al. Oximes: Reactivators of phosphorylated acetylcholinesterase and antidotes in therapy against tabun poisoning. Chem Biol Interact 2008; 175: 173–9. <https://doi.org/10.1016/j.cbi.2008.04.011>
19. Kovarik Z, Lucic Vrdoljak A, Berend S et al. Evaluation of oxime K203 as antidote in tabun poisoning. Arh Hig Rada Toksikol 2009; 60: 19–26. <https://doi.org/10.2478/10004-1254-60-2009-1890>
20. Kuca K, Musilek K, Jun D et al. Could oxime HI‑6 really be considered as “broad‑spectrum” antidote? J Appl Biomed 2009; 7: 143–9. <https://doi.org/10.32725/jab.2009.016>
21. Kuca K, Picha J, Cabal J, Liska F. Synthesis of the three monopyridinium oximes and evaluation of their potency to reactivate acetylcholinesterase inhibited by nerve agents. J Appl Biomed 2004; 2: 51–6. <https://doi.org/10.32725/jab.2004.006>
22. Lawrence DT, Kirk MA. Chemical terrorism attacks: update on antidotes. Emerg Med Clin N Am 2007; 25: 567–95. <https://doi.org/10.1016/j.emc.2007.02.002>
23. Lorke DE, Hasan MY, Nurulain SM, Kuca K, Schmitt A, Petroianu GA. Efficacy of two asymmetric bispyridinium oximes (K‑27 and K‑48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI‑6. Toxicol Mech Method 2009; 19: 327–33. <https://doi.org/10.1080/15376510902798695>
24. Lotti M. Organophosphorus compounds. In: Spencer PS, Schaumburg HH, eds. Experimental and Clinical Neurotoxicology. New York: Oxford University Press, 2000: 898–925.
25. Lundy PM, Raveh L, Amitai G. Development of the bisquaternary oxime HI‑6 toward clinical use in the treatment of organophosphate nerve agent poisoning. Toxicol Rev 2006; 25: 231–43. <https://doi.org/10.2165/00139709-200625040-00004>
26. Luo CY, Tong M, Chilukuri N, Brecht K, Maxwell DM, Saxena A. An in vitro comparative study on the reactivation of nerve agent‑inhibited guinea‑pig and human acetylcholinesterases by oximes. Biochemistry 2007; 48: 11771–9. <https://doi.org/10.1021/bi701002f>
27. Maksimovic M, Kovacevic V. Protective and reactivating effects of HI‑6‑toxogonin mixture in rats and guinea‑pigs poisoned by nerve agents. Acta Pharm Jugoslav 1989; 39: 27–33.
28. Marrs TC, Rice P, Vale JA. The role of oximes in the treatment of nerve agent poisoning in civilian casualties. Toxicol Rev 2006; 25: 297–323. <https://doi.org/10.2165/00139709-200625040-00009>
29. Maxwell DM, Koplovitz I, Worek F, Sweeney RE. A structure‑activity analysis of the variation in oxime efficacy against nerve agents. Toxicol Appl Pharmacol 2008; 231: 157–64. <https://doi.org/10.1016/j.taap.2008.04.007>
30. Musilek K, Holas O, Kuca K et al. Synthesis of monooxime‑monocarbamoyl bispyridinium compounds bearing (E)‑but‑2‑ene linker and evaluation of their reactivation activity against tabun‑ and paraoxon‑inhibited acetylcholinesterase. J Enzym Inhib Med Chem 2008; 23: 70–6. <https://doi.org/10.1080/14756360701383981>
31. Musilek K, Kuca K, Jun D, Dolezal M. Progress in synthesis of new acetylcholinesterase reactivators in period 1990–2004. Curr Org Chem 2007; 11: 229–38. <https://doi.org/10.2174/138527207779316417>
32. Nurulain SM, Lorke DE, Hasan MY et al. Efficacy of eight experimental bispyridinium oximes against paraoxon‑induced mortality: comparison with the conventional oximes pralidoxime and obidoxime. Neurotox Res 2009; 16: 60–7. <https://doi.org/10.1007/s12640-009-9048-7>
33. Ohtomi S, Takase M, Kumagai F. Sarin poisoning in Japan. A clinical experience in Japan Self Defense Force (JSDF) Central Hospital. Int Rev Arm Ser 1996; 69: 97–102.
34. Szinicz L, Worek F, Thiermann H, Kehe K, Eckert S, Eyer P. Development of antidotes: problems and strategies. Toxicology 2007; 233: 23–30. <https://doi.org/10.1016/j.tox.2006.07.008>
35. Tallarida R, Murray R. Manual of Pharmacological Calculation with Computer Programs. New York: Springer‑Verlag, 1987: 195.
36. Worek F, Aurbek N, Thiermann H. Reactivation of organophosphate‑inhibited human AChE by combinations of obidoxime and HI 6 in vitro. J Appl Toxicol 2007; 27: 582–8. <https://doi.org/10.1002/jat.1241>
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