Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis

Pohl, David; Andrýs, Ctirad; Borská, Lenka; Fiala, Zdeněk; Hamáková, Květoslava; Ettler, Karel; Krejsek, Jan

doi:10.14712/18059694.2016.19

Acta Medica > Archive > 2011, Vol. 54 > Issue 2 > Serum Level of a Soluble Form of…

Acta Med. 2011, 54: 59-62

https://doi.org/10.14712/18059694.2016.19

Serum Level of a Soluble Form of Endoglin (CD105) is Decreased after Goeckerman’s Therapy of Psoriasis

David Pohl^a, Ctirad Andrýs^a, Lenka Borská^b, Zdeněk Fiala^c, Květoslava Hamáková^d, Karel Ettler^d, Jan Krejsek^a

^aCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergy, Czech Republic
^bCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Pathological Physiology, Czech Republic
^cCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Hygiene and Preventive Medicine, Czech Republic
^dCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Dermatology and Venereology, Czech Republic

Received July 8, 2010
Accepted January 18, 2011

Background. Goeckerman’s therapy (GT) of psoriasis is based on daily application of pharmacy grade coal tar on affected skin with subsequent exposure to UV light. Disturbances in angiogenic activity are characteristic for the immunopathogenesis of psoriasis. The aim of study was to evaluate the influence of GT of psoriasis on proinflammatory and angiogenic activities expressed as changes in levels of endoglin (CD105). Methods. Serum levels of a soluble form of endoglin were measured in peripheral blood samples of 38 patients with psoriasis before and after therapy. Sixty three otherwise healthy blood donors serve as a control group. The efficacy of GT was expressed as changes in Psoriasis Area and Severity Index (PASI). Results. PASI score was significantly diminished by GT (p<0.001). Serum levels of soluble CD105 were significantly diminished after GT. The serum level of soluble CD105 dropped from 7.85 ± 2.26 ng/ml before therapy to 7.01 ± 1.71 ng/ml after therapy (p= 0.0002). Compared to serum levels of soluble CD105 in healthy blood donors, serum levels of soluble CD105 in patients before GT were significantly higher (p<0.001) and remained elevated after therapy (p<0.001). Angiogenic activity expressed as serum endoglin is diminished in patients with psoriasis treated by GT.

Keywords

Psoriasis, Goeckerman’s therapy, Angiogenesis, Endoglin, CD105.

Funding

This study was supported by Ministry of Health, Czech Republic, Research project MZO 00179906 and by Ministry of Education, Czech Republic project No. MSM 002 1620812.