Gestational Diabetes Mellitus in Primigravidae: a Mild Disease

Ismail, Nor Azlin Mohamed; Aris, Norkhatijah Mohd; Mahdy, Zaleha Abdullah; Ahmad, Shuhaila; Naim, Norzilawati Mohd; Siraj, Harlina Harlizah Hj; Zakaria, Syed Zulkifli Syed

doi:10.14712/18059694.2016.12

Acta Medica > Archive > 2011, Vol. 54 > Issue 1 > Gestational Diabetes Mellitus in…

Acta Med. 2011, 54: 21-24

https://doi.org/10.14712/18059694.2016.12

Gestational Diabetes Mellitus in Primigravidae: a Mild Disease

Nor Azlin Mohamed Ismail^a, Norkhatijah Mohd Aris^b, Zaleha Abdullah Mahdy^a, Shuhaila Ahmad^a, Norzilawati Mohd Naim^a, Harlina Harlizah Hj Siraj^a, Syed Zulkifli Syed Zakaria^b

^aUniversiti Kebangsaan Malaysia, Faculty of Medicine, Department of Obstetrics and Gynaecology, Kuala Lumpur, Malaysia
^bUniversiti Kebangsaan Malaysia, Medical Molecular Biology Institute, Kuala Lumpur, Malaysia

Received June 30, 2010
Accepted December 20, 2010

This prospective observational study was done to analyse the prevalence of gestational diabetes mellitus (GDM) among primigravidae and its outcome. All healthy primigravidae with singleton pregnancies were offered universal glucose tolerance testing between 16 and 28 weeks gestation. GDM and non GDM groups were managed according to hospital protocol. The antenatal features and pregnancy outcomes were analysed. Out of 616 primigravidae, 113 (18.34 %) were GDM with slightly older (27.9 ± 4.2 versus 26.32 ± 3.3, p < 0.001) age. The mean fasting and two hours postprandial blood glucose in both groups were 4.99 ± 1.08 mmol/l, 8.86 ± 1.41 mmol/l(GDM) and 4.36 ± 0.43 mmol/l, 5.71 ± 1.11 mmol/l (Non GDM), respectively. Maternal family history of diabetes mellitus, weight exceeding 80 Kg, polyhydramnios (2.65 % versus 0.2 %, p=0.028) and neonatal hyperbilirubinaemia (9.73 % versus 2.98 %, p=0.01) occurred significantly more frequent in the GDM group compared to normal. There was no significant difference in other pregnancy outcomes and complications between the two groups. In conclusion GDM in primigravidae was detected at a relatively young age with more frequent maternal family history of DM, weight exceeding 80 Kg, polyhydromnions and neonatal hyperbilirubinaemia. The degree of disease was mild and treatment led to no significant complication.