Acta Med. 2010, 53: 221-224
Effects of Early Therapeutic Administration of Interleukin-1β on Survival Rate and Bone Marrow Hemopoiesis of Irradiated Mice
The study was aimed at the experimental assessment of the efficacy of recombinant interleukin-1β in the early therapy of haemopoiesis disorders caused by X-ray irradiation. The efficacy of the product was based on the 30-day survival rate and average life expectancy of dead animals. Endogenous and exogenous colony-formations were studied to reveal possible mechanisms of therapeutic effects of interleukin-1β on the bone marrow. The early administration (10–15 min after exposure to radiation) of recombinant interleukin-1β in a dose of 50 μg/kg increased the survival rate and prevented the post-irradiation decrease in the number of endogenous and exogenous CFU-S9 in irradiated mice.
Keywords
Irradiation, Interleukin-1β, Radiation injury, Therapeutic efficacy, Survival rate, Haemopoiesis.
References
Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.
