Acta Med. 2010, 53: 73-77

https://doi.org/10.14712/18059694.2016.63

Regulatory T cells (Treg) and Their Roles in Immune System with Respect to Immunopathological Disorders

Kateřina Kondělkováa, Doris Vokurkováa, Jana Krejseka, Lenka Borskáb, Zdeněk Fialac, Ctirad Andrýsa

aCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech Republic
bCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Institute of Pathological Physiology, Hradec Králové, Czech Republic
cCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Institute of Hygiene and Preventive Medicine, Hradec Králové, Czech Republic

Received January 21, 2010
Accepted March 18, 2010

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  • ten Brink Tim, Damanik Febriyani, Rotmans Joris I., Moroni Lorenzo: Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes. Adv Healthcare Materials 2024. <https://doi.org/10.1002/adhm.202301939>
  • Dias-Carvalho Ana, Sá Susana Isabel, Carvalho Félix, Fernandes Eduarda, Costa Vera Marisa: Inflammation as common link to progressive neurological diseases. Arch Toxicol 2024, 98, 95. <https://doi.org/10.1007/s00204-023-03628-8>
  • Ghosh Sushruta, Bhatti Gurjit Kaur, Sharma Pushpender Kumar, Kandimalla Ramesh, Mastana Sarabjit Singh, Bhatti Jasvinder Singh: Potential of Nano-Engineered Stem Cells in the Treatment of Multiple Sclerosis: A Comprehensive Review. Cell Mol Neurobiol 2024, 44. <https://doi.org/10.1007/s10571-023-01434-5>
  • Arabameri Abazar, Arab Samaneh: Understanding the Interplay of CAR-NK Cells and Triple-Negative Breast Cancer: Insights from Computational Modeling. Bull Math Biol 2024, 86. <https://doi.org/10.1007/s11538-023-01247-z>
  • Borlongan Mia C., Saha Dipongkor, Wang Hongbin: Tumor Microenvironment: A Niche for Cancer Stem Cell Immunotherapy. Stem Cell Rev and Rep 2024, 20, 3. <https://doi.org/10.1007/s12015-023-10639-6>
  • Lansberry T.R., Stabler C.L.: Immunoprotection of cellular transplants for autoimmune type 1 diabetes through local drug delivery. Advanced Drug Delivery Reviews 2024, 206, 115179. <https://doi.org/10.1016/j.addr.2024.115179>
  • Pirsadeghi Ali, Namakkoobi Negar, Behzadi Mahtab Sharifzadeh, Pourzinolabedin Hanieh, Askari Fatemeh, Shahabinejad Erfan, Ghorbani Somayeh, Asadi Fatemeh, Hosseini-Chegeni Ali, Yousefi-Ahmadipour Aliakbar, Kamrani Mohammad Hossein: Therapeutic approaches of cell therapy based on stem cells and terminally differentiated cells: Potential and effectiveness. Cells & Development 2024, 177, 203904. <https://doi.org/10.1016/j.cdev.2024.203904>
  • Russo Angela E., Memon Areeba, Ahmed Shahid: Bladder Cancer and the Urinary Microbiome—New Insights and Future Directions: A Review. Clinical Genitourinary Cancer 2024, 22, 434. <https://doi.org/10.1016/j.clgc.2023.12.015>
  • Rewerska Barbara, Sher Lawrence D., Alpizar Sady, Pauser Sylvia, Pulka Grazyna, Mozaffarian Neelufar, Salhi Yacine, Martinet Camille, Jabert Wafaa, Gudi Girish, CA Vinu, GN Sunitha, Macoin Julie, Anstett Victor, Turrini Riccardo, Doucey Marie-Agnès, Blein Stanislas, Konto Cyril, Machkova Martina: Phase 2b randomized trial of OX40 inhibitor telazorlimab for moderate-to-severe atopic dermatitis. Journal of Allergy and Clinical Immunology: Global 2024, 3, 100195. <https://doi.org/10.1016/j.jacig.2023.100195>
  • Desai Sharav A., Patel Vipul P., Bhosle Kunal P., Nagare Sandip D., Thombare Kirti C.: The tumor microenvironment: shaping cancer progression and treatment response. Journal of Chemotherapy 2024, 1. <https://doi.org/10.1080/1120009X.2023.2300224>
  • Chan Chun Lai, Sugimura Ryohichi: Unveiling the immune system aging in single-cell resolution. Journal of Leukocyte Biology 2024, 115, 16. <https://doi.org/10.1093/jleuko/qiad136>
  • Lee Sun-Ah, Cho Gi-Ju, Kim Doyoung, Kim Dong-Hwee: Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis. Front. Cell Dev. Biol. 2024, 12. <https://doi.org/10.3389/fcell.2024.1335636>
  • Zhang Yunhong, Zhang Zhen, Li Haoyang, Chu Chu, Liang Gang, Fan Nannan, Wei Ran, Zhang Tingting, Li Lihua, Wang Bin, Li Xia: Increased miR-6132 promotes deep vein thrombosis formation by downregulating FOXP3 expression. Front. Cardiovasc. Med. 2024, 11. <https://doi.org/10.3389/fcvm.2024.1356286>
  • Ozmen Ece, Demir Tevriz Dilan, Ozcan Gulnihal: Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer. Front. Mol. Biosci. 2024, 11. <https://doi.org/10.3389/fmolb.2024.1340124>
  • Bharuka Tanvi, Reche Amit: Advancements in Periodontal Regeneration: A Comprehensive Review of Stem Cell Therapy. Cureus 2024. <https://doi.org/10.7759/cureus.54115>
  • Zajac Kelsee K., Malla Saloni, Babu Ramapuram Jayachandra, Raman Dayanidhi, Tiwari Amit K.: Ethnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes. Cancer Reports 2023, 6. <https://doi.org/10.1002/cnr2.1779>
  • Afzali Shima, Mohammadisoleimani Elham, Mansoori Yaser, Mohaghegh Poopak, Bahmanyar Maryam, Mansoori Behnam, Pezeshki Babak, Nikfar Ghasem, Tavassoli Alireza, Shahi Abbas, Moravej Ali: The potential roles of Th17 cells in the pathogenesis of oral lichen planus. Inflamm. Res. 2023, 72, 1513. <https://doi.org/10.1007/s00011-023-01763-7>
  • Halder Suvankar, Chatterjee Samrat: Bistability regulates TNFR2-mediated survival and death of T-regulatory cells. J Biol Phys 2023, 49, 95. <https://doi.org/10.1007/s10867-023-09625-3>
  • Ganesh Sanjeev K., Subathra Devi C.: Molecular and therapeutic insights of rapamycin: a multi-faceted drug from Streptomyces hygroscopicus. Mol Biol Rep 2023, 50, 3815. <https://doi.org/10.1007/s11033-023-08283-x>
  • Rosado Mitchell R. Sanchez, Marzan-Rivera Nicole, Watowich Marina M., Valle Andrea D. Negron-Del, Pantoja Petraleigh, Pavez-Fox Melissa A., Siracusa Erin R., Cooper Eve B., Valle Josue E. Negron-Del, Phillips Daniel, Ruiz-Lambides Angelina, Martinez Melween I., Montague Michael J., Platt Michael L., Higham James P., Brent Lauren J. N., Snyder-Mackler Noah, Martinez Melween I., Montague Michael J., Platt Michael L., Higham James P., Brent Lauren J. N., Sariol Carlos A., Snyder-Mackler Noah: Immune cell composition varies by age, sex and exposure to social adversity in free-ranging Rhesus Macaques. GeroScience 2023, 46, 2107. <https://doi.org/10.1007/s11357-023-00962-8>
  • Singh Sumeet, Gouri Vinita, Samant Mukesh: TGF-β in correlation with tumor progression, immunosuppression and targeted therapy in colorectal cancer. Med Oncol 2023, 40. <https://doi.org/10.1007/s12032-023-02204-5>
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  • Al Zein Mohammad, Boukhdoud Mona, Shammaa Hadi, Mouslem Hadi, El Ayoubi Lemir Majed, Iratni Rabah, Issa Khodr, Khachab Maha, Assi Hazem I., Sahebkar Amirhossein, Eid Ali H.: Immunotherapy and immunoevasion of colorectal cancer. Drug Discovery Today 2023, 28, 103669. <https://doi.org/10.1016/j.drudis.2023.103669>
  • Goodin Dylan A., Frieboes Hermann B.: Evaluation of innate and adaptive immune system interactions in the tumor microenvironment via a 3D continuum model. Journal of Theoretical Biology 2023, 559, 111383. <https://doi.org/10.1016/j.jtbi.2022.111383>
  • Omotainse Oluwadamilola S., Wawegama Nadeeka K., Kulappu Arachchige Sathya N., Coppo Mauricio C., Vaz Paola K., Saliha Uneeb, Bogeski Mirjana, Noormohammadi Amir H., Stent Andrew W.: Th-1 cytotoxic cell-mediated response predominates in the tracheal mucosa following Mycoplasma synoviae infection of MS-H-vaccinated chickens. Veterinary Microbiology 2023, 109921. <https://doi.org/10.1016/j.vetmic.2023.109921>
  • Fallarini Silvia, Cerofolini Linda, Salobehaj Maria, Rizzo Domenico, Gheorghita Giulia Roxana, Licciardi Giulia, Capialbi Daniela Eloisa, Zullo Valerio, Sodini Andrea, Nativi Cristina, Fragai Marco: Site-Selective Functionalized PD-1 Mutant for a Modular Immunological Activity against Cancer Cells. Biomacromolecules 2023, 24, 5428. <https://doi.org/10.1021/acs.biomac.3c00893>
  • Zhou Mengli, Liang Shuang, Liu Dan, Ma Kongshuo, Yun Kaiqing, Yao Jianjun, Peng Yuxuan, Hai Linna, Zhang Qiang, Wang Zhaohui: Manganese-Enriched Zinc Peroxide Functional Nanoparticles for Potentiating Cancer Immunotherapy. Nano Lett. 2023, 23, 10350. <https://doi.org/10.1021/acs.nanolett.3c02941>
  • Lao Peizhen, Chen Jingyi, Tang Longqian, Zhang Jiwen, Chen Yuxi, Fang Yuyin, Fan Xingliang: Regulatory T cells in lung disease and transplantation. Bioscience Reports 2023, 43. <https://doi.org/10.1042/BSR20231331>
  • Ríos-Rivera Rafael A., Vilá Luis M., Saadeh Constantine: Coexistent Relapsing Polychondritis and Clinically Amyopathic Dermatomyositis: A Rare Association of Autoimmune Disorders. Case Reports in Rheumatology 2023, 2023, 1. <https://doi.org/10.1155/2023/3719502>
  • Ahmad Aatiya, Khan Parvez, Rehman Asad Ur, Batra Surinder Kumar, Nasser Mohd Wasim: Immunotherapy: an emerging modality to checkmate brain metastasis. Mol Cancer 2023, 22. <https://doi.org/10.1186/s12943-023-01818-7>
  • Yavari Abolfazl, Zare Fateme, Hadinedoushan Hossein, Tahoori Mohammad Taher: The effect of the anti-leukemia inhibitory factor on the immune system in the Balb/c mice bearing breast cancer induced with 4T1 cells. Eur J Med Res 2023, 28. <https://doi.org/10.1186/s40001-023-01196-2>
  • Kılınc Mehmet, Colkesen Fatih, Evcen Recep, Sadi Aykan Filiz, Yıldız Eray, Onalan Tugba, Yılmaz Ergun Ummugulsum, Akkus Fatma Arzu, Arslan Sevket: Relationship between autoimmune diseases and serum basal immunoglobulin E levels in patients with common variable immunodeficiency. allergy asthma proc 2023, 44, e11. <https://doi.org/10.2500/aap.2023.44.230025>
  • Benson Lance N., Guo Yunping, Deck Katherine, Mora Christoph, Liu Yunmeng, Mu Shengyu: The link between immunity and hypertension in the kidney and heart. Front. Cardiovasc. Med. 2023, 10. <https://doi.org/10.3389/fcvm.2023.1129384>
  • Roy Gargi, Chakraborty Anush, Swami Bharati, Pal Lalit, Ahuja Charvi, Basak Soumen, Bhaskar Sangeeta: Type 1 interferon mediated signaling is indispensable for eliciting anti-tumor responses by Mycobacterium indicus pranii. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1104711>
  • Gu QinLei, Tung Kenneth S., Lorenz Ulrike M.: Treg-specific deletion of the phosphatase SHP-1 impairs control of inflammation in vivo. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1139326>
  • Nazki Salik, Reddy Vishwanatha R. A. P., Kamble Nitin, Sadeyen Jean-Remy, Iqbal Munir, Behboudi Shahriar, Shelton Holly, Broadbent Andrew J.: CD4+TGFβ+ cells infiltrated the bursa of Fabricius following IBDV infection, and correlated with a delayed viral clearance, but did not correlate with disease severity, or immunosuppression. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1197746>
  • Arain Hania, Patel Tina, Mureanu Nicoleta, Efthymiou Athina, Lombardi Giovanna, Tree Timothy, Nicolaides Kypros H., Shangaris Panicos: Regulatory T cells in the peripheral blood of women with gestational diabetes: a systematic review and meta-analysis. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1226617>
  • Huang Pengfei, Zhou Xinyue, Zheng Minying, Yu Yongjun, Jin Gongsheng, Zhang Shiwu: Regulatory T cells are associated with the tumor immune microenvironment and immunotherapy response in triple-negative breast cancer. Front. Immunol. 2023, 14. <https://doi.org/10.3389/fimmu.2023.1263537>
  • Calvillo-Robledo Argelia, Ramírez-Farías Cynthia, Valdez-Urias Fernando, Huerta-Carreón Erika P., Quintanar-Stephano Andrés: Arginine vasopressin hormone receptor antagonists in experimental autoimmune encephalomyelitis rodent models: A new approach for human multiple sclerosis treatment. Front. Neurosci. 2023, 17. <https://doi.org/10.3389/fnins.2023.1138627>
  • Lamouline Anaïs, Bersini Simone, Moretti Matteo: In vitro models of breast cancer bone metastasis: analyzing drug resistance through the lens of the microenvironment. Front. Oncol. 2023, 13. <https://doi.org/10.3389/fonc.2023.1135401>
  • Woo Jong Kyu, Kim Tae-Geuk, Im Na Yeon, Son Ka-Yeon, Cho Minhyeon, Jeong Yeo Jin, Hong Jeong-Im, Kang BoRim, Enkhtaivan Gansukh, Cho Nam-Hyuk, Alain Tommy, Park Dong Guk, Lee Yeon-Sook: Dual-Armed Oncolytic Myxoma Virus Encoding IFN-γ and CD47 Promotes Lymphocyte Infiltration and Tumor Suppression of Syngeneic Murine Melanoma. Cancers 2023, 15, 4703. <https://doi.org/10.3390/cancers15194703>
  • Sinha Aashna, Kumar Sudhashekhar, Dayal Deen, Yadav Vaishali, Pramanik Atreyi, Chaubey Kundan Kumar, Kumar Sanjay: Elimination of lymphatic filariasis: Where do we stand so far?. Asian Pacific Journal of Tropical Medicine 2023, 16, 385. <https://doi.org/10.4103/1995-7645.380729>
  • Malla Rama Rao, Vasudevaraju Padmaraju, Vempati Rahul Kumar, Rakshmitha Marni, Merchant Neha, Nagaraju Ganji Purnachandra: Regulatory T cells: Their role in triple‐negative breast cancer progression and metastasis. Cancer 2022, 128, 1171. <https://doi.org/10.1002/cncr.34084>
  • Lopez Emma Muiños, Leclerc Kevin, Ramsukh Malissa, Parente Paulo EL, Patel Karan, Aranda Carlos J., Josephson Anna M., Remark Lindsey H., Kirby David J., Buchalter Daniel B., Hadi Tarik, Morgani Sophie M., Ramkhelawon Bhama, Leucht Philipp: Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging. Bone 2022, 157, 116324. <https://doi.org/10.1016/j.bone.2021.116324>
  • Mobasheri Leila, Nasirpour Mohammad Hossein, Masoumi Elham, Azarnaminy Afsaneh Foolady, Jafari Mozhdeh, Esmaeili Seyed-Alireza: SARS-CoV-2 triggering autoimmune diseases. Cytokine 2022, 154, 155873. <https://doi.org/10.1016/j.cyto.2022.155873>
  • Soleimanpour Saman, Yaghoubi Atieh, Sadat Seddighinia Fereshteh, Rezaee S.A. Rahim: A century of attempts to develop an effective tuberculosis vaccine: Why they failed?. International Immunopharmacology 2022, 109, 108791. <https://doi.org/10.1016/j.intimp.2022.108791>
  • Bund Virginie, Azaïs Henri, Bibi-Triki Sabrina, Lecointre Lise, Betrian Sarah Bétrian, Angeles Martina Aida, Eberst Lauriane, Faller Emilie, Boisramé Thomas, Bendifallah Sofiane, Akladios Chérif, Deluche Élise: Basics of immunotherapy for epithelial ovarian cancer. Journal of Gynecology Obstetrics and Human Reproduction 2022, 51, 102283. <https://doi.org/10.1016/j.jogoh.2021.102283>
  • Albekairi Norah A., Nadeem Ahmed, Ansari Mushtaq A., Attia Sabry M., Bakheet Saleh A., Alanazi Mohammed M., Alhamed Abdullah S., Albekairi Thamer H., Al-Mazroua Haneen A., Ibrahim Khalid E., Ahmad Sheikh F.: CXCR2 antagonist SB332235 mitigates deficits in social behavior and dysregulation of Th1/Th22 and T regulatory cell-related transcription factor signaling in male BTBR T+ Itpr3tf/J mouse model of autism. Pharmacology Biochemistry and Behavior 2022, 217, 173408. <https://doi.org/10.1016/j.pbb.2022.173408>
  • Pabst L., Lopes S., Kotovskaya M., Bertrand B., Mascaux C.: Biomarqueurs en immunothérapie, signatures moléculaires, radiomique : avons-nous avancé ?. Revue des Maladies Respiratoires Actualités 2022, 14, 2S225. <https://doi.org/10.1016/S1877-1203(22)00122-7>
  • Yao Yi-En, Qin Cai-Cheng, Yang Chao-Mian, Huang Tian-Xia: γδT17/γδTreg cell subsets: a new paradigm for asthma treatment. Journal of Asthma 2022, 59, 2028. <https://doi.org/10.1080/02770903.2021.1980585>
  • Moghaddam Maryam Zare, Ansariniya Hossein, Seifati Seyed Mohammad, Zare Fateme, Fesahat Farzaneh: Immunopathogenesis of endometriosis: An overview of the role of innate and adaptive immune cells and their mediators. American J Rep Immunol 2022, 87. <https://doi.org/10.1111/aji.13537>
  • Wang Shujie, Wang Gang, Tang Yan-Dong, Li Siqi, Qin Lei, Wang Menghang, Yang Yong-Bo, Gottschalk Marcelo, Cai Xuehui, Dragoi Ana-Maria: Streptococcus suis Serotype 2 Infection Induces Splenomegaly with Splenocyte Apoptosis. Microbiol Spectr 2022, 10. <https://doi.org/10.1128/spectrum.03210-22>
  • Antwi Stephen, Oduro-Mensah Daniel, Asiedu-Larbi Jerry, Oduro-Mensah Ebenezer, Quasie Olga, Lewis Clara, Darko-Obiri David, Ocloo Augustine, Okine Laud Kenneth: Prophylactic or therapeutic administration of Holarrhena floribunda hydro ethanol extract suppresses complete Freund’s adjuvant-induced arthritis in Sprague-Dawley rats. J Inflamm 2022, 19. <https://doi.org/10.1186/s12950-022-00301-2>
  • Asemani Yahya, Najafi Sajad, Ezzatifar Fatemeh, Zolbanin Naime Majidi, Jafari Reza: Recent highlights in the immunomodulatory aspects of Treg cell-derived extracellular vesicles: special emphasis on autoimmune diseases and transplantation. Cell Biosci 2022, 12. <https://doi.org/10.1186/s13578-022-00808-4>
  • Jung Woo-Sang, Kwon Seungwon, Yang Jung Yun, Jin Chul, Cho Seung-Yeon, Park Seong-Uk, Moon Sang-Kwan, Park Jung-Mi, Ko Chang-Nam, Bae Hyunsu, Cho Ki-Ho: CD206+ dendritic cells might be associated with Heat-pattern and induced regulatory T cells after treatment with bee venom. J Korean Med 2022, 43, 1. <https://doi.org/10.13048/jkm.22015>
  • Kinash M. I., Boyarchuk O. R.: Pyridoxine, folate, and cobalamin and the condition of the innate and acquired immunity. Ukr. Biochem. J. 2022, 94, 5. <https://doi.org/10.15407/ubj94.01.005>
  • Ekpruke Carolyn Damilola, Silveyra Patricia: Sex Differences in Airway Remodeling and Inflammation: Clinical and Biological Factors. Front. Allergy 2022, 3. <https://doi.org/10.3389/falgy.2022.875295>
  • Xiao Haihan, Xiao Haijuan, Zhang Yun, Guo Lingyun, Dou Zhenzhen, Liu Linlin, Zhu Liang, Feng Wenya, Liu Bing, Hu Bing, Chen Tianming, Liu Gang, Wen Tingyi: High-throughput sequencing unravels the cell heterogeneity of cerebrospinal fluid in the bacterial meningitis of children. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.872832>
  • Ryan Nathan M., Lamenza Felipe F., Upadhaya Puja, Pracha Hasan, Springer Anna, Swingler Michael, Siddiqui Arham, Oghumu Steve: Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.932742>
  • Li Sicong, Li Lanxing, Pan Tianyan, Li Xiaoqun, Tong Yujia, Jin Yongdong: Prognostic value of TIGIT in East Asian patients with solid cancers: A systematic review, meta-analysis and pancancer analysis. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.977016>
  • Qiu Yiran, Ke Shouyu, Chen Jieqiong, Qin Zhizhen, Zhang Wenle, Yuan Yaqin, Meng Dehua, Zhao Gang, Wu Kejin, Li Bin, Li Dan: FOXP3+ regulatory T cells and the immune escape in solid tumours. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.982986>
  • Zaher Amira, Stephens Laura M., Miller Ann M., Hartwig Stacey M., Stolwijk Jeffrey M., Petronek Michael S., Zacharias Zeb R., Wadas Thaddeus J., Monga Varun, Cullen Joseph J., Furqan Muhammad, Houtman Jon C. D., Varga Steven M., Spitz Douglas R., Allen Bryan G.: Pharmacological ascorbate as a novel therapeutic strategy to enhance cancer immunotherapy. Front. Immunol. 2022, 13. <https://doi.org/10.3389/fimmu.2022.989000>
  • Park Hye Eun, Oh Hanna, Baek Jea-Hyun: Interleukin-34-regulated T-cell responses in rheumatoid arthritis. Front. Med. 2022, 9. <https://doi.org/10.3389/fmed.2022.1078350>
  • Xie Qingqing, Zhang Pengfei, Wang Yuanyuan, Mei Wuxuan, Zeng Changchun: Overcoming resistance to immune checkpoint inhibitors in hepatocellular carcinoma: Challenges and opportunities. Front. Oncol. 2022, 12. <https://doi.org/10.3389/fonc.2022.958720>
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  • Chauhan Priyanka, Hu Shuxian, Sheng Wen S., Lokensgard James R.: Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia. Cells 2022, 11, 2826. <https://doi.org/10.3390/cells11182826>
  • Koopman Nienke, Remijas Lauren, Seppen Jurgen, Setlow Peter, Brul Stanley: Mechanisms and Applications of Bacterial Sporulation and Germination in the Intestine. IJMS 2022, 23, 3405. <https://doi.org/10.3390/ijms23063405>
  • Hudec Michael, Juříčková Iva, Riegerová Kamila, Ovsepian Saak V., Černá Marie, O’Leary Valerie Bríd: Enhanced Extracellular Transfer of HLA-DQ Activates CD3+ Lymphocytes towards Compromised Treg Induction in Celiac Disease. IJMS 2022, 23, 6102. <https://doi.org/10.3390/ijms23116102>
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  • Dotse Eunice, Lim King H., Wang Meijun, Wijanarko Kevin Julio, Chow Kwan T.: An Immunological Perspective of Circulating Tumor Cells as Diagnostic Biomarkers and Therapeutic Targets. Life 2022, 12, 323. <https://doi.org/10.3390/life12020323>
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  • Finkina Ekaterina I., Bogdanov Ivan V., Ignatova Anastasia A., Kanushkina Marina D., Egorova Ekaterina A., Voropaev Alexander D., Stukacheva Elena A., Ovchinnikova Tatiana V.: Antifungal Activity, Structural Stability, and Immunomodulatory Effects on Human Immune Cells of Defensin from the Lentil Lens culinaris. Membranes 2022, 12, 855. <https://doi.org/10.3390/membranes12090855>
  • Mulherkar Tania H., Gómez Daniel Joseph, Sandel Grace, Jain Pooja: Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses. Viruses 2022, 14, 2037. <https://doi.org/10.3390/v14092037>
  • Benson Lance N., Liu Yunmeng, Deck Katherine, Mora Christoph, Mu Shengyu: IFN-γ Contributes to the Immune Mechanisms of Hypertension. Kidney360 2022, 3, 2164. <https://doi.org/10.34067/KID.0001292022>
  • Fan Weiqiang, Ma Huan, Jin Bin: Expression of FOXM1 and PLK1 predicts prognosis of patients with hepatocellular carcinoma. Oncol Lett 2022, 23. <https://doi.org/10.3892/ol.2022.13266>
  • Moses Abraham S., Demessie Ananiya A., Taratula Olena, Korzun Tetiana, Slayden Ov D., Taratula Oleh: Nanomedicines for Endometriosis: Lessons Learned from Cancer Research. Small 2021, 17. <https://doi.org/10.1002/smll.202004975>
  • Curtis Louis T., Sebens Susanne, Frieboes Hermann B.: Modeling of tumor response to macrophage and T lymphocyte interactions in the liver metastatic microenvironment. Cancer Immunol Immunother 2021, 70, 1475. <https://doi.org/10.1007/s00262-020-02785-4>
  • Ghosh Sanhita, Roy Kamalika, Rajalingam Radhakrishnan, Martin Sunil, Pal Chiranjib: Cytokines in the generation and function of regulatory T cell subsets in leishmaniasis. Cytokine 2021, 147, 155266. <https://doi.org/10.1016/j.cyto.2020.155266>
  • Lotfi Ramin, Nasiri Kalmarzi Rasoul, Rajabinejad Misagh, Hasani Sabah, Zamani Fatemeh: The role of immune semaphorins in the pathogenesis of multiple sclerosis: Potential therapeutic targets. International Immunopharmacology 2021, 95, 107556. <https://doi.org/10.1016/j.intimp.2021.107556>
  • Mansourabadi Amir Hossein, Mohamed Khosroshahi Leila, Noorbakhsh Farshid, Amirzargar Aliakbar: Cell therapy in transplantation: A comprehensive review of the current applications of cell therapy in transplant patients with the focus on Tregs, CAR Tregs, and Mesenchymal stem cells. International Immunopharmacology 2021, 97, 107669. <https://doi.org/10.1016/j.intimp.2021.107669>
  • Santosa Damai, Sofro Muchlis A. U., Farida, Nindita Nurvita, Pangarsa Eko A., Setiawan Budi, Rizky Daniel, Suharti Catharina: A full-term pregnant woman with secondary Evans syndrome caused by severe coronavirus disease 2019: a case report. J Med Case Reports 2021, 15. <https://doi.org/10.1186/s13256-021-03205-6>
  • Chen Yan, Sun Zepang, Chen Wanlan, Liu Changyan, Chai Ruoyang, Ding Jingjing, Liu Wen, Feng Xianzhen, Zhou Jun, Shen Xiaoyi, Huang Shan, Xu Zhongqing: The Immune Subtypes and Landscape of Gastric Cancer and to Predict Based on the Whole-Slide Images Using Deep Learning. Front. Immunol. 2021, 12. <https://doi.org/10.3389/fimmu.2021.685992>
  • Lee E Hui Clarissa, Wong Darren Chen Pei, Ding Jeak Ling: NK Cells in a Tug-of-War With Cancer: The Roles of Transcription Factors and Cytoskeleton. Front. Immunol. 2021, 12. <https://doi.org/10.3389/fimmu.2021.734551>
  • Principe Daniel R., Chiec Lauren, Mohindra Nisha A., Munshi Hidayatullah G.: Regulatory T-Cells as an Emerging Barrier to Immune Checkpoint Inhibition in Lung Cancer. Front. Oncol. 2021, 11. <https://doi.org/10.3389/fonc.2021.684098>
  • Truong Nga T. H., Gargett Tessa, Brown Michael P., Ebert Lisa M.: Effects of Chemotherapy Agents on Circulating Leukocyte Populations: Potential Implications for the Success of CAR-T Cell Therapies. Cancers 2021, 13, 2225. <https://doi.org/10.3390/cancers13092225>
  • Dutta Avik, Venkataganesh Harini, Love Paul E.: New Insights into Epigenetic Regulation of T Cell Differentiation. Cells 2021, 10, 3459. <https://doi.org/10.3390/cells10123459>
  • Bule Pedro, Aguiar Sandra Isabel, Aires-Da-Silva Frederico, Dias Joana Nunes Ribeiro: Chemokine-Directed Tumor Microenvironment Modulation in Cancer Immunotherapy. IJMS 2021, 22, 9804. <https://doi.org/10.3390/ijms22189804>
  • Jimbu Laura, Mesaros Oana, Popescu Cristian, Neaga Alexandra, Berceanu Iulia, Dima Delia, Gaman Mihaela, Zdrenghea Mihnea: Is There a Place for PD-1-PD-L Blockade in Acute Myeloid Leukemia?. Pharmaceuticals 2021, 14, 288. <https://doi.org/10.3390/ph14040288>
  • Kim Youngji, Kobayashi Eisuke, Suehara Yoshiyuki, Ito Ayumu, Kubota Daisuke, Tanzawa Yoshikazu, Endo Makoto, Nakatani Fumihiko, Nakatsura Tetsuya, Kawai Akira, Kaneko Kazuo, Kitano Shigehisa: Immunological status of peripheral blood is associated with prognosis in patients with bone and soft-tissue sarcoma. Oncol Lett 2021, 21. <https://doi.org/10.3892/ol.2021.12473>
  • Keam Synat, Gill Suki, Ebert Martin A, Nowak Anna K, Cook Alistair M: Enhancing the efficacy of immunotherapy using radiotherapy. Clin & Trans Imm 2020, 9. <https://doi.org/10.1002/cti2.1169>
  • Idzikowski Emma, Connors Thomas J.: Impact and Clinical Implications of Prematurity on Adaptive Immune Development. Curr Pediatr Rep 2020, 8, 194. <https://doi.org/10.1007/s40124-020-00234-5>
  • Zheng Ke, Wu Si-zhi, Lv Yi-wen, Pang Peng, Deng Li, Xu Hua-chong, Shi Yu-cong, Chen Xiao-yin: Carvacrol inhibits the excessive immune response induced by influenza virus A via suppressing viral replication and TLR/RLR pattern recognition. Journal of Ethnopharmacology 2020, 113555. <https://doi.org/10.1016/j.jep.2020.113555>
  • de Carvalho José Tarcísio Giffoni, Da Silva Baldivia Debora, de Castro David Tsuyoshi Hiramatsu, dos Santos Helder Freitas, dos Santos Cintia Miranda, Oliveira Alex Santos, Alfredo Tamaeh Monteiro, Vilharva Kellen Natalice, de Picoli Souza Kely, dos Santos Edson Lucas: The immunoregulatory function of polyphenols: implications in cancer immunity. The Journal of Nutritional Biochemistry 2020, 85, 108428. <https://doi.org/10.1016/j.jnutbio.2020.108428>
  • Devi Karam, Singh Nirmal, Jaggi Amteshwar Singh: Dual role of sirtuin 1 in inflammatory bowel disease. Immunopharmacology and Immunotoxicology 2020, 42, 385. <https://doi.org/10.1080/08923973.2020.1790595>
  • Xu Ling‐Zhi, Xie Rui‐Di, Xie Hai, Ju Ji‐Yu, Fu Xiao‐Yan, Di Da‐Lin, Peng Mei‐Yu, Gao Wei, Zhang Yuan‐Yi, Yu Dian, Liu Jiang‐Qi, Yang Gui, Liu Zhi‐Qiang, Liu Zhi-Gang, Yang Ping-Chang: Chimeric specific antigen epitope‐carrying dendritic cells induce interleukin‐17(+) regulatory T cells to suppress food allergy. Clin Experimental Allergy 2020, 50, 231. <https://doi.org/10.1111/cea.13528>
  • Collins Kimberly S., Cheng Ying‐Hua, Ferreira Ricardo M., Gao Hongyu, Dollins Matthew D., Janosevic Danielle, Khan Nida A., White Chloe, Dagher Pierre C., Eadon Michael T.: Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers. Clinical Translational Sci 2020, 13, 1137. <https://doi.org/10.1111/cts.12795>
  • Jung Hak-Jun, Park Su-Ho, Cho Kyung-Min, Jung Kwang Il, Cho Daeho, Kim Tae Sung: Threonyl-tRNA Synthetase Promotes T Helper Type 1 Cell Responses by Inducing Dendritic Cell Maturation and IL-12 Production via an NF-κB Pathway. Front. Immunol. 2020, 11. <https://doi.org/10.3389/fimmu.2020.571959>
  • Huggard Dean, Doherty Derek G., Molloy Eleanor J.: Immune Dysregulation in Children With Down Syndrome. Front. Pediatr. 2020, 8. <https://doi.org/10.3389/fped.2020.00073>
  • Marchant Vanessa, Tejera-Muñoz Antonio, Marquez-Expósito Laura, Rayego-Mateos Sandra, Rodrigues-Diez Raul R., Tejedor Lucia, Santos-Sanchez Laura, Egido Jesús, Ortiz Alberto, Valdivielso Jose M., Fraser Donald J., López-Cabrera Manuel, Selgas Rafael, Ruiz-Ortega Marta: IL-17A as a Potential Therapeutic Target for Patients on Peritoneal Dialysis. Biomolecules 2020, 10, 1361. <https://doi.org/10.3390/biom10101361>
  • Falcone Italia, Conciatori Fabiana, Bazzichetto Chiara, Ferretti Gianluigi, Cognetti Francesco, Ciuffreda Ludovica, Milella Michele: Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy. Cancers 2020, 12, 2870. <https://doi.org/10.3390/cancers12102870>
  • Ahmad Imran, Valverde Araceli, Ahmad Fayek, Naqvi Afsar Raza: Long Noncoding RNA in Myeloid and Lymphoid Cell Differentiation, Polarization and Function. Cells 2020, 9, 269. <https://doi.org/10.3390/cells9020269>
  • Cannas Daniela, Loi Eleonora, Serra Matteo, Firinu Davide, Valera Paolo, Zavattari Patrizia: Relevance of Essential Trace Elements in Nutrition and Drinking Water for Human Health and Autoimmune Disease Risk. Nutrients 2020, 12, 2074. <https://doi.org/10.3390/nu12072074>
  • Imas José Javier, Ruiz Zamarreño Carlos, Zubiate Pablo, Sanchez-Martín Lorena, Campión Javier, Matías Ignacio Raúl: Optical Biosensors for the Detection of Rheumatoid Arthritis (RA) Biomarkers: A Comprehensive Review. Sensors 2020, 20, 6289. <https://doi.org/10.3390/s20216289>
  • Popova N. N., Savchenko V. G.: Reconstitution of T-cell-mediated immunity in patients after allogeneic stem cell transplantation. Gematologiâ i transfuziologiâ 2020, 65, 24. <https://doi.org/10.35754/0234-5730-2020-65-1-24-38>
  • Acharya Suman, Timilshina Maheshwor, Chang Jae-Hoon: Mevalonate promotes differentiation of regulatory T cells. J Mol Med 2019, 97, 927. <https://doi.org/10.1007/s00109-019-01784-y>
  • Matta Samantha M., Hill-Yardin Elisa L., Crack Peter J.: The influence of neuroinflammation in Autism Spectrum Disorder. Brain, Behavior, and Immunity 2019, 79, 75. <https://doi.org/10.1016/j.bbi.2019.04.037>
  • Mahlbacher Grace E., Reihmer Kara C., Frieboes Hermann B.: Mathematical modeling of tumor-immune cell interactions. Journal of Theoretical Biology 2019, 469, 47. <https://doi.org/10.1016/j.jtbi.2019.03.002>
  • Wu Yi‐Ying, Hsieh Chin‐Tung, Tsay Gregory J., Kao Jung‐Ta, Chiu Ying‐Ming, Shieh Dong‐Chen, Lee Yi‐Ju: Recruitment of CCR6+ Foxp3+ regulatory gastric infiltrating lymphocytes in Helicobacter pylori gastritis. Helicobacter 2019, 24. <https://doi.org/10.1111/hel.12550>
  • Sun Sheng-Wen, Chen Long, Zhou Mei, Wu Jiang-Hua, Meng Zhao-Ji, Han Hong-Li, Miao Shuai-Ying, Zhu Chen-Chen, Xiong Xian-Zhi: BAMBI regulates macrophages inducing the differentiation of Treg through the TGF-β pathway in chronic obstructive pulmonary disease. Respir Res 2019, 20. <https://doi.org/10.1186/s12931-019-0988-z>
  • Garretti Francesca, Agalliu Dritan, Lindestam Arlehamn Cecilia S., Sette Alessandro, Sulzer David: Autoimmunity in Parkinson's Disease: The Role of α-Synuclein-Specific T Cells. Front. Immunol. 2019, 10. <https://doi.org/10.3389/fimmu.2019.00303>
  • Fong Alexis, Durkin Amanda, Lee Hoyun: The Potential of Combining Tubulin-Targeting Anticancer Therapeutics and Immune Therapy. IJMS 2019, 20, 586. <https://doi.org/10.3390/ijms20030586>
  • Lan Xu, Wang Grace, Xu Xiaoxi, Lu Shanzheng, Li Xiang, Zhang Baoren, Shi Ganggang, Zhao Yiming, Du Caigan, Wang Hao: Stromal Cell-Derived Factor-1 Mediates Cardiac Allograft Tolerance Induced by Human Endometrial Regenerative Cell-Based Therapy. Stem Cells Translational Medicine 2017, 6, 1997. <https://doi.org/10.1002/sctm.17-0091>
  • Ahmad Suhana, Zamry Anes Ateqah, Tan Hern-Tze Tina, Wong Kah Keng, Lim JitKang, Mohamud Rohimah: Targeting dendritic cells through gold nanoparticles: A review on the cellular uptake and subsequent immunological properties. Molecular Immunology 2017, 91, 123. <https://doi.org/10.1016/j.molimm.2017.09.001>
  • Mansour Iman, Zayed Rania A., Said Fadwa, Latif Lamyaa Abdel: Indoleamine 2,3-dioxygenase and regulatory T cells in acute myeloid leukemia. Hematology 2016, 21, 447. <https://doi.org/10.1080/10245332.2015.1106814>
  • Li Haijun, Liu Qixiao, Jiang Yuanyuan, Zhang Yi, Xiao Wei, Zhang Yan: Disruption of Th17/Treg Balance in the Sputum of Patients With Chronic Obstructive Pulmonary Disease. The American Journal of the Medical Sciences 2015, 349, 392. <https://doi.org/10.1097/MAJ.0000000000000447>
  • Vaz Emília R., Fujimura Patrícia T., Araujo Galber R., da Silva Carlos A. T., Silva Rangel L., Cunha Thiago M., Lopes-Ferreira Mônica, Lima Carla, Ferreira Márcio J., Cunha-Junior Jair P., Taketomi Ernesto A., Goulart Luiz R., Ueira-Vieira Carlos, Ryffel Bernhard: A Short Peptide That Mimics the Binding Domain of TGF-β1 Presents Potent Anti-Inflammatory Activity. PLoS ONE 2015, 10, e0136116. <https://doi.org/10.1371/journal.pone.0136116>
  • Cruvinel Wilson de Melo, Mesquita Júnior Danilo, Araújo Júlio Antônio Pereira, Samazi Karina Carvalho, Kállas Esper Georges, Cendoroglo Maysa Seabra, Andrade Luis Eduardo Coelho: Abnormal phenotypic distribution of regulatory and effector T cells in octogenarian and nonagenarian women. Rev. Assoc. Med. Bras. 2015, 61, 329. <https://doi.org/10.1590/1806-9282.61.04.329>
  • GOGACZ MAREK, WINKLER IZABELA, BOJARSKA-JUNAK AGNIESZKA, TABARKIEWICZ JACEK, SEMCZUK ANDRZEJ, RECHBERGER TOMASZ, ADAMIAK ANETA: T regulatory lymphocytes in patients with endometriosis. Molecular Medicine Reports 2014, 10, 1072. <https://doi.org/10.3892/mmr.2014.2294>
  • Hao Xing, Han Junyan, Xing Zhichen, Hao Yu, Jiang Chunjing, Zhang Jianping, Yang Jing, Hou Xiaotong: Urinary Trypsin Inhibitor Attenuated Inflammatory Response of Patients Undergoing Cardiopulmonary Bypass by Inducing Activated Treg Cells. Inflammation 2013, 36, 1279. <https://doi.org/10.1007/s10753-013-9666-3>
  • Olkowska-Truchanowicz J., Bocian K., Maksym R. B., Bialoszewska A., Wlodarczyk D., Baranowski W., Zabek J., Korczak-Kowalska G., Malejczyk J.: CD4+ CD25+ FOXP3+ regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis. Human Reproduction 2013, 28, 119. <https://doi.org/10.1093/humrep/des346>
  • Dong Xiaojun, Gong Yu, Zeng Hui, Hao Yu, Wang Xianbo, Hou Jing, Wang Jiefei, Li Juan, Zhu Yueke, Liu Haixia, Han Junyan, Zhou Haiwei, Shen Liwei, Gao Ting, Zhou Tingting, Yang Shuyin, Li Shuting, Chen Yingxuan, Meng Qinghua, Li Hai: Imbalance between circulating CD4+ regulatory T and conventional T lymphocytes in patients with HBV‐related acute‐on‐chronic liver failure. Liver International 2013, 33, 1517. <https://doi.org/10.1111/liv.12248>
  • Fondell Elinor, Axelsson John, Franck Kristina, Ploner Alexander, Lekander Mats, Bälter Katarina, Gaines Hans: Short natural sleep is associated with higher T cell and lower NK cell activities. Brain, Behavior, and Immunity 2011, 25, 1367. <https://doi.org/10.1016/j.bbi.2011.04.004>
  • Sbiera Silviu, Dexneit Thomas, Reichardt Sybille D., Michel Kai D., van den Brandt Jens, Schmull Sebastian, Kraus Luitgard, Beyer Melanie, Mlynski Robert, Wortmann Sebastian, Allolio Bruno, Reichardt Holger M., Fassnacht Martin, Meuth Sven G.: Influence of Short-Term Glucocorticoid Therapy on Regulatory T Cells In Vivo. PLoS ONE 2011, 6, e24345. <https://doi.org/10.1371/journal.pone.0024345>
  • Corsini Emanuela, Oukka Mohamed, Pieters Raymond, Kerkvliet Nancy I., Ponce Rafael, Germolec Dori R.: Alterations in regulatory T-cells: Rediscovered pathways in immunotoxicology. Journal of Immunotoxicology 2011, 8, 251. <https://doi.org/10.3109/1547691X.2011.598885>
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