Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response

Tichý, Aleš; Vávrová, Jiřina; Pejchal, Jaroslav; Řezáčová, Martina

doi:10.14712/18059694.2016.57

Acta Medica > Archive > 2010, Vol. 53 > Issue 1 > Ataxia-telangiectasia Mutated Kinase…

Acta Med. 2010, 53: 13-17

https://doi.org/10.14712/18059694.2016.57

Ataxia-telangiectasia Mutated Kinase (ATM) as a Central Regulator of Radiation-induced DNA Damage Response

Aleš Tichý^a,b, Jiřina Vávrová^b, Jaroslav Pejchal^c, Martina Řezáčová^a

^aCharles University in Praha, Faculty of Medicine and University Hospital Hradec Králové, Department of Medical Biochemistry, Hradec Králové, Czech Republic
^bUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Radiobiology, Hradec Králové, Czech Republic
^cUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Centre of Advanced Studies, Hradec Králové, Czech Republic

Received February 10, 2010
Accepted March 8, 2010

Ataxia-telangiectasia mutated kinase (ATM) is a DNA damage-inducible protein kinase, which phosphorylates plethora of substrates participating in DNA damage response. ATM significance for the cell faith is undeniable, since it regulates DNA repair, cell-cycle progress, and apoptosis. Here we describe its main signalling targets and discuss its importance in DNA repair as well as novel findings linked to this key regulatory enzyme in the terms of ionizing radiationinduced DNA damage.