Acta Med. 2008, 51: 173-179

https://doi.org/10.14712/18059694.2017.20

Expression of Intermediate Filament Nestin in Blood Vessels of Neural and Non-neural Tissues

Jaroslav Mokrýa, Jiří Ehrmannb, Jana Karbanováa, Dana Čížkováa, Tomáš Soukupa, Jakub Suchánekc, Stanislav Filipa,d, Zdeněk Kolářb

aCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Histology and Embryology, Hradec Králové, Czech Republic
bPalacky University Medical Faculty, Department of Pathology, Olomouc, Czech Republic
cCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Dentistry, Hradec Králové, Czech Republic
dCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Oncology and Radiotherapy, Hradec Králové, Czech Republic

Received June 1, 2008
Accepted September 1, 2008

References

1. Aihara M, Sugawara K, Torii S et al. Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab Invest 2004; 84:1581–92. <https://doi.org/10.1038/labinvest.3700186>
2. Alliot F, Rutin J, Leenen PJM, Pessac B. Pericytes and periendothelial cells of brain parenchyma vessels co-express aminopeptidase N, aminopeptidase A, and nestin. J Neurosci Res 1999; 58:367–78. <https://doi.org/10.1002/(SICI)1097-4547(19991101)58:3<367::AID-JNR2>3.0.CO;2-T>
3. Almqvist PM, Mah R, Lendahl U, Jacobsson B, Hendson G. Immunohistochemical detection of nestin in pediatric brain tumors. J Histochem Cytochem 2002; 50:147–58. <https://doi.org/10.1177/002215540205000203>
4. Amoh Y, Yang M, Li L et al. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res 2005; 65:5352–7. <https://doi.org/10.1158/0008-5472.CAN-05-0821>
5. Beltrami AP, Barlucchi L, Torella D et al. Adult cardiac stem cells are multipotent and support myocardium regeneration. Cell 2003; 114:763–76. <https://doi.org/10.1016/S0092-8674(03)00687-1>
6. Chou YH, Khuon S, Herrmann H, Goldman RD. Nestin promotes the phosphorylation- dependent disassembly of vimentin intermediate filaments during mitosis. Mol Biol Cell 2003; 14:1468–78. <https://doi.org/10.1091/mbc.E02-08-0545> <PubMed>
7. Dahlstrand J, Collins VP, Lendahl U. Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res 1992; 52: 5334–41.
8. Frederiksen K, McKay RDG. Proliferation and differentiation of rat neuroepithelial precursor cells in vivo. J Neurosci 1988; 8:1144–51. <https://doi.org/10.1523/JNEUROSCI.08-04-01144.1988> <PubMed>
9. Frojdman K, Pellieniemi LJ, Lendahl U, Virtanen I, Eriksson JE. The intermediate filament protein nestin occurs transiently in differentiating testis of rat and mouse. Differentiation 1997; 61:243–9. <https://doi.org/10.1046/j.1432-0436.1997.6140243.x>
10. Hockfield S, McKay RDG. Identification of major cell classes in the developing mammalian nervous system. J Neurosci 1985; 5:3310–28. <https://doi.org/10.1523/JNEUROSCI.05-12-03310.1985> <PubMed>
11. Kachinsky AM, Dominov JA, Miller JB. Myogenesis and the intermediate filament protein, nestin. Dev Biol 1994; 165:216–28. <https://doi.org/10.1006/dbio.1994.1248>
12. Kolář Z, Ehrmann J, Turashvili G, Bouchal J, Mokrý J. A novel myoepithelial/ progenitor cell marker in the breast? Virchows Arch 2007; 450:607–9. <https://doi.org/10.1007/s00428-007-0403-x>
13. Lendahl U, Zimmerman LB, McKay RDG. CNS stem cells express a new class of intermediate filament protein. Cell 1990; 60:585–95. <https://doi.org/10.1016/0092-8674(90)90662-X>
14. Mokrý J, Čížková D, Filip S et al. Nestin expression by newly formed human blood vessels. Stem Cells Dev 2004; 13:658–64. <https://doi.org/10.1089/scd.2004.13.658>
15. Mokrý J, Němeček S. Angiogenesis of extra- and intraembryonic blood vessels is associated with expression of nestin in endothelial cells. Folia Biol (Prague) 1998; 44:155–61.
16. Mokrý J, Němeček S. Cerebral angiogenesis shows nestin expression in endothelial cells. Gen Physiol Biophys 1999; 18:25–9.
17. Mokrý J, Pudil R, Ehrmann J et al. Re-expression of nestin in the myocardium of postinfarcted patients. Virchows Arch 2008.
18. Sahlgren CM, Mikhailov A, Hellman J et al. Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. J Biol Chem 2001; 276:16456–63. <https://doi.org/10.1074/jbc.M009669200>
19. Sejersen T, Lendahl U. Transient expression of the intermediate filament nestin during skeletal muscle development. J Cell Sci 1993; 106:1291–1300.
20. Sjoberg G, Jiang WQ, Ringertz NR, Lendahl U, Sejersen T. Colocalization of nestin and vimentin/ desmin in skeletal muscle cells demonstrated by threedimensional fluorescence digital imaging microscopy. Exp Cell Res 1994; 214: 447–58. <https://doi.org/10.1006/excr.1994.1281>
21. Steinert PM, Chou YH, Prahland V et al. A high molecular weight intermediate filament-associated protein in BHK-21 cells is nestin, a type VI intermediate filament protein. Limited co-assembly in vitro to form heteropolymers with type III vimentin and type IV α-internexin. J Biol Chem 1999; 274:9881–90. <https://doi.org/10.1074/jbc.274.14.9881>
22. Sugawara K, Kurihara H, Negishi M et al. Nestin as a marker for proliferative endothelium in gloimas. Lab Invest 2002; 82:345–51. <https://doi.org/10.1038/labinvest.3780428>
23. Terling C, Rass A, Mitsiadis TA, Fried K, Lendahl U, Wroblewski J. Expression of the intermediate filament nestin during rodent tooth development. Int J Dev Biol 1995; 39:947–56.
24. Tohyama T, Lee WMY, Rorke LB, Marvin M, McKay RDG, Trojanowski JQ. Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Lab Invest 199; 66:303–13.
25. Wagner N, Wagner KD, Scholz H, Kirschner KM, Schedl A. Intermediate filament protein nestin is expressed in developing kidney and heart and might be regulated by the Wilms’ tumor suppressor Wt1. Am J Physiol Regul Integr Comp Physiol 2006; 291:R779–87. <https://doi.org/10.1152/ajpregu.00219.2006>
26. Witmer AN, vanBlijswijk BC, vanNoorden CJF, Vrensen GFJM, Schlingemann RO. In vivo angiogenic phenotype of endothelial cells and pericytes induced by vascular endothelial growth factor-A. J Histochem Cytochem 2004; 52:39–52. <https://doi.org/10.1177/002215540405200105>
27. Wurmser AE, Nakashima K, Summers RG et al. Cell fusion-independent differentiation of neural stem cells to the endothelial lineage. Nature 2004; 430: 350–56. <https://doi.org/10.1038/nature02604>
front cover

ISSN 1211-4286 (Print) ISSN 1805-9694 (Online)

Open access journal

Archive