Ionizing Radiation Sensitizes Leukemic MOLT-4 Cells to TRAIL-induced Apoptosis

Řezáčová, Martina; Vávrová, Jiřina; Vokurková, Doris

doi:10.14712/18059694.2017.10

Acta Medica > Archive > 2008, Vol. 51 > Issue 2 > Ionizing Radiation Sensitizes Leukemic…

Acta Med. 2008, 51: 101-105

https://doi.org/10.14712/18059694.2017.10

Ionizing Radiation Sensitizes Leukemic MOLT-4 Cells to TRAIL-induced Apoptosis

Martina Řezáčová^a, Jiřina Vávrová^b, Doris Vokurková^c

^aCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Department of Medical Biochemistry, Hradec Králové, Czech Republic
^bUniversity of Defense, Faculty of Military Health Sciences, Hradec Králové, Czech Republic
^cCharles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Institute of Clinical Immunology and Allergology, Hradec Králové, Czech Republic

Received February 1, 2008
Accepted April 1, 2008

One of perspective approaches in treatment of hematological malignancies is activation of death receptors for TRAIL. However, leukemia cells studied to date have shown variable susceptibility to TRAIL. Our study demonstrates that cells of acute T-lymphoblastic leukemia MOLT-4 are resistant to TRAIL and that ionizing radiation in the therapeutically achievable dose of 1 Gy sensitizes TRAIL-resistant cells MOLT-4 to the TRAIL-induced apoptosis by increase in death receptors for TRAIL DR5. When TRAIL is applied after the irradiation in the time of increased DR5 positivity more efficient cell killing is achieved.