Acta Med. 2007, 50: 233-238

The Inflammatory Radicular Cysts Have Higher Concentration of TNF-α in Comparison to Odontogenic Keratocysts (Odontogenic Tumour)

Vladimir Jurisica, Snjezana Colicb, Milan Jurisicb

aUniversity of Kragujevac, School of Medicine, Kragujevc, Serbia
bUniversity of Belgrade Clinic for Oral Surgery, School of Dentistry, Belgrade, Serbia

Received September 1, 2007
Accepted September 1, 2007


1. Agaram NP, Collins B, Barnes L, Lomado D, Aldeeb D, Swalsky P et al. Molecular analysis to demonstrated that odontogenic keratocyst are neoplastic. Arch Pathol Lab Med, 2004; 30:596–76.
2. Bando Y, Henderson B, Meghji S, Poole S, Harris M. Immunocytochemical localisation of inflammatory cytokines and vascular adhesion receptors in radicular cysts. J Oral Pathol Med. 1993; 22:221–7. <>
3. Barnes L, Eveson JW, Reichard P, Sidransky D. World Health Organization classification of tumours. Pathology and Genetics. Head and Neck tumours. Lion: IARC press; 2005.
4. Barreto DC, Bale AE, De Marco L, Gomez RS. Immunolocalisation of PTHC protein in odontogenic cyst and tumors. J Dent Res, 2002; 81:757–60. <>
5. Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumor necrosis factor. Nature. 1986; 319:516–18. <>
6. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodont Res. 1993; 28:500–10. <>
7. Bletsa A, Berggreen E, Brudvik P. Interleukin-1 a and tumor necrosis factor–α expression during the early phases of orthodonic tooth movement in rats. Eur J Oral Sci, 2006; 114:423–9. <>
8. Colic M, Lukic A, Vucevic D, Milosavljevic P, Majstorovic I, Marjanovic M, Dimitrijevic J. Correlation between phenotypic chracteristics of mononuclear cells isolated from human periapical lesions and their in vitro production of Th1 and Th2 cytokines. Archives of Oral Biology, 2006; 12:1120–30. <>
9. Danin J, Linder L, Lundqvist G, Wretlind B. Cytokines in periradicular lesion: efects of linezolid treatment. Orl Sur Oral Med Oral Pathol Oral Radiol Endod, 2003; 96:492–8. <>
10. Garlet GP, Martins S Jr, Ferreira BR, Milanezi CM, Silva JS. Patterns of chemokines and chemokine receptors expression in different forms of human periodontal disease. J Periodontal Res. 2003; 38:210–217. <>
11. Honma M, Hayakawa Y, Kosugi H, Koizumi F. Localisation of mRNA for inflammatory cytokines in radicular cyst tissue by in situ hybridization, and induction of inflammatory cytokines by human gingival fibroblast in responce to radicular cyst contents. J Oral Path Med. 1998; 27:399–404. <>
12. Jurisic V, Bogdanovic G, Kojic V, Jakimov D, Srdic T. TNF-α effects on Raji cells at different cellular level estimated by various methods. Ann Haematology. 2006; 85:86–94. <>
13. Jurisic V, Bogdanovic G, Srdic T, Jakimov D, Mrdjanovic J, Baltic M, Baltic V.V. Modulation of TNF-α activity in tumor PC cells using anti-CD45 and anti CD95 monoclonal antibody. Cancer Lett. 2004; 214:55–61. <>
14. Jurisic V, Spuzic I, Konjevic G. A comparison of NK cell activity with effects of TNF-α against K-562 cells, determined by LDH release assay. Cancer Lett. 1999; 138:67–72. <>
15. Kakaranatza-Angelopoulon E, Nicolaton O. Odontogenic keratocysts. J Oral Maxillofac Surg 1990; 48:593–9. <>
16. Kaneyama K, Segami N, Sun W, Sato J, Fujimura K. Analysis of tumor necrosis factor-α, interleukin-6, interleukin-1β, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor agonist and protein in the synovial fluid of patients with temporomandibular joint disorders. Oral Sur Oral Med Oral Pathol Oral Radiolo Endod. 2005; 99:276–84. <>
17. Krammer IRH, Pindborg JJ, Shear M. Histological typing of odontogenic tumors, 2nd edn. Berlin, Heidelberg: Springer-Verlag, 1992;34–42.
18. Mattews JB, Mason GI, Browne RM. Epithelial cell markers and proliferating cells in odontogenic jaw cysts. J Pathol 1988; 156:283–90. <>
19. Meghji S, Qureshi W, Henderson B, Harris M. The role of endotoxin and cytokines in the pathogenesis of odontogenic cysts. Arch Oral Biol 1996; 41:523–31. <>
20. Ninomiya T, Kubota Y, Koji T, Shirasuna K. Marsupialization inhibits interleukin-1a expresion and epithelial cell proliferation i odontogenic keratocysts. J Oral Pathol Med 2002; 31:526–33. <>
21. Ohsima M, Nishiyama T, Tokunaga K, Sato S, Maeno M, Otsuka K. Profiles of cytokine expression in radicular cyst-lining epithelium examinated by RT-PCR. J Oral Science. 2000; 42:239–246. <>
22. Silva T, Lara VS, Rosa AL, Cuhna FQ. Cytokine and chemokine response of bone cells after dentil challenge in vitro. Oral Diseases. 2004; 10:258–64. <>
23. Souza CG, Gomez RS. Odontogenic keratocyst: a benign cystic neoplasm? Oral Oncology, 2006 in press.
24. Stashenko P, Wang Cun Y, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 1994; 78:494–502. <>
25. Takeichi O, Saito I, Tsurumachi T, Moro I, Saito T. Expression of inflammatory cytokines genes in vivo by human alveolar bone derived polymorphonuclear leukocytes isolated from chronically inflamed sites of bone resortion. Calcified Tissue International, 1996; 58:244–8.
26. Thomson BM, Mundy GR, Chambers TJ. Tumor necrosis factor-α and β induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunology. 1987; 138:775–9.
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