Acta Med. 2007, 50: 93-99
The Inflammatory Response in Cardiac Surgery. An Up-to-date Overview with the Emphasis on the Role of Heat Shock Proteins (HSPs) 60 and 70
Cardiac surgical operations are associated with the development of a systemic inflammatory response syndrome (SIRS). In most cases, the inflammatory response is apparent only in its subclinical form. In some cases, however, it can become clinically manifest or even life-threatening. This review article presents some new data regarding its biological importance, along with an insight into the recently discovered role played by heat shock proteins 60 and 70.
Keywords
Cardiac surgery, Ischemia and reperfusion, Inflammation, Innate immunity, Heat shock proteins, Lipopolysaccharide, CD14 receptor, Toll-like receptors, Dendritic cells.
Funding
This work has been supported by a research program of The Czech Ministry of Youth, Scholarship and Physical Activities No. MSM 0021620812 and Internal Grant Agency of Ministry of Health, Czech Republic, No. NR/9090-4.
References
Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.
