Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Kuča, Kamil; Pícha, Jan; Jun, Daniel

doi:10.14712/18059694.2017.138

Acta Medica > Archive > 2006, Vol. 49 > Issue 4 > Reactivation Potency of New Group of…

Acta Med. 2006, 49: 233-235

https://doi.org/10.14712/18059694.2017.138

Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes

Kamil Kuča^a,b, Jan Pícha^c, Daniel Jun^a,b

^aUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Centre of Advanced Studies, Hradec Králové, Czech Republic
^bUniversity of Defence in Brno, Faculty of Military Health Sciences in Hradec Králové, Department of Toxicology, Hradec Králové, Czech Republic
^cPrague Institute of Chemical Technology, Department of Organic Chemistry, Prague, Czech Republic

Received June 1, 2006
Accepted November 1, 2006

In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. Currently available oximes (pralidoxime, obidoxime, trimedoxime, HI-6 and BI-6) were used as oximes for comparison. As resulted, none of tested new reactivators was able to reactivate AChE inhibited by cyclosarin. Also pralidoxime, obidoxime and trimedoxime did not reach good reactivation results. Only oximes HI-6 and BI-6 achieved sufficient reactivation potency. From obtained results, it can be deduced, that only reactivators with oxime group in position two are able to reactivate cyclosarin-inhibited AChE.

Keywords

Oxime, Reactivator, Acetylcholinesterase, Cyclosarin.

Funding

This work was supported by Grant Agency of the Czech Republic (grant No. 203/01/1093) and Ministry of Defense of the Czech Republic, grant – “New method of prophylaxis, decontamination, diagnosis and therapy in the case of intoxication with nerve agents and sulfur mustard“.