Acta Med. 2006, 49: 233-235
https://doi.org/10.14712/18059694.2017.138
Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes
References
1. J, Kuča K, Kassa J. Specification of the structure of oximes able to reactivate tabun inhibited acetylcholinesterase. Bas Clin Pharmacol Toxicol 2004; 95: 81–6.
<https://doi.org/10.1111/j.1742-7843.2004.950207.x>
2. SR, Vobalaboina V, Garlapati A. Quaternary salts of 4,3’ and 4,4’bis-pyridinium monooximes: Synthesis and biological activity. Bioorg Med Chem Lett 2005; 15: 3076–80.
<https://doi.org/10.1016/j.bmcl.2005.04.026>
3. AP. Design and structure-activity relationships of antidotes to organophosphorus anticholinesterase agents. Drug Met Rev 1984; 15: 557–9.
<https://doi.org/10.3109/03602538409029973>
4. J. Review of oximes in the antidotal treatment of poisoning by organophosphorus nerve agents. J Toxicol Clin Toxicol 2002; 40: 803–16.
<https://doi.org/10.1081/CLT-120015840>
5. J, Bajgar J. Changes of acetylcholinesterase activity in various parts of brain following nontreated and treated soman poisoning in rats. Mol Chem Neuropathol 1998; 33: 175–84.
<https://doi.org/10.1007/BF02815180>
6. J, Cabal J. A comparison of the efficacy of a new asymmetric bispyridinium oxime BI-6 with currently available oximes and H oximes against soman by in vitro and in vivo methods. Toxicology 1999; 132: 111–8.
<https://doi.org/10.1016/S0300-483X(98)00146-2>
7. J, Cabal J. A comparison of the efficacy of acetylcholine reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods. Pharmacol Toxicol 1999; 84: 41–6.
<https://doi.org/10.1111/j.1600-0773.1999.tb02109.x>
8. TH, Kuča K, Jun D, Jung YS. Design and synthesis of new bis-pyridinium oximes as cyclosarin-inhibited acetylcholinesterase reactivators. Bioorg Med Chem Lett 2005; 15: 2914–17.
<https://doi.org/10.1016/j.bmcl.2005.03.060>
9. K, Jun D, Musilek K. Structural requirements of acetylcholinesterase reactivators. Mini Rev Med Chem 2006; 6: 269–77.
<https://doi.org/10.2174/138955706776073510>
10. K, Cabal J. Evaluation of newly synthesized reactivators of the brain cholinesterase inhibited by sarin-nerve agent. Toxicol Mech Meth 2005; 15: 247–52.
<https://doi.org/10.1080/15376520590968770>
11. K, Patočka J. Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium–Oximes. J Enzyme Inhib Med Chem 2004; 19: 39–43.
<https://doi.org/10.1080/1475636031000163850>
12. YP, Kollmeyer TM, Hong F, Lee JC, Hammond PI, Haugabouk SP, Brimijoin S. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol 2003; 10: 491–502.
<https://doi.org/10.1016/S1074-5521(03)00126-1>
13. J, Kuča K, Kivala M, Kohout M, Cabal J, Liška F. New group of monoquaternary reactivators of the acetylcholinesterase inhibited by nerve agents. J Enzyme Inhib Med Chem 2005; 20: 233–7.
<https://doi.org/10.1080/14756360400021858>
14. F, Kirchner T, Bäcker M, Szinicz L. Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compounds. Arch Toxicol 1996; 70: 497–503.
<https://doi.org/10.1007/s002040050304>
15. GY, Yoon JH, Seong CM, Park NS, Jung YS. Synthesis of Bis-pyridinium oxime antidotes using bis(methylsulfonoxymethyl) ether for organophosphate nerve agents. Bull Korean Chem Soc 2003; 24: 1368–70.


