Acta Med. 2006, 49: 233-235
Reactivation Potency of New Group of Acetylcholinesterase Reactivators and Their Comparison with Currently Available Oximes
In this work, in vitro potency of novel serie of monoquaternary pyridinium oximes to reactivate cyclosarin-inhibited acetylcholinesterase (AChE) was tested. Currently available oximes (pralidoxime, obidoxime, trimedoxime, HI-6 and BI-6) were used as oximes for comparison. As resulted, none of tested new reactivators was able to reactivate AChE inhibited by cyclosarin. Also pralidoxime, obidoxime and trimedoxime did not reach good reactivation results. Only oximes HI-6 and BI-6 achieved sufficient reactivation potency. From obtained results, it can be deduced, that only reactivators with oxime group in position two are able to reactivate cyclosarin-inhibited AChE.
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Funding
This work was supported by Grant Agency of the Czech Republic (grant No. 203/01/1093) and Ministry of Defense of the Czech Republic, grant – “New method of prophylaxis, decontamination, diagnosis and therapy in the case of intoxication with nerve agents and sulfur mustard“.
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Copyright
Published by the Karolinum Press. For permission to use please write to actamedica@lfhk.cuni.cz.