Acta Med. 2006, 49: 189-192

Docetaxel Labeled with Iodine 131 Radionuclide – A Possible New Anticancer Drug? (The Pilot Study)

Jiří Pasteraa, Emil Rudolfb, Milan Dittrichc

aInstitute of Experimental Biopharmaceutics, Joint Research Center of Czech Academy of Sciences and PRO.MED.CS Praha, Hradec Králové, Czech Republic
bCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Medical Biology and Genetics, Hradec Králové, Czech Republic
cCharles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Technology, Hradec Králové, Czech Republic

Received July 1, 2006
Accepted September 1, 2006


1. Al-Mufti RA, Pedley RB, Marshall D et al. In vitro assessment of Lipiodol-targeted radiotherapy for liver and colorectal cancer cell lines. Br J Cancer 1999; 79:1665–71. <> <PubMed>
2. Araki S, Miyagi Y, Kawanishi K et al. Neoadjuvant treatment with docetaxel and the effects of irradiation for human ovarian adenocarcinoma and cervical squamous cell carcinoma in vitro. Acta Med Okayama 2002; 56:13–8.
3. Cozzi PJ, Clingan PR, Glenn D, Morris DL. Lipiodol is concentrated by liver metastases from leiomyosarcoma: Prospects for therapy? Reg Cancer Treat 1995; 8:156–9.
4. Curran WJ. New chemotherapeutic agents: update of major chemoradiation trials in solid tumors. Oncology 2002; 63 Suppl 2:29–38. <>
5. Hind RE, Loizidou M, Perring S et al. Biodistribution of Lipiodol following hepatic arterial injection. Br J Surg 1992; 79:952–4. <>
6. Choy H. Combining Taxanes with radiation for solid tumors. Int J Cancer (Radiat Oncol Invest) 2000; 90:113–27. <<113::AID-IJC1>3.0.CO;2-C>
7. Kiesewetter DO, Jagoda EM, Kao CH et al. Fluoro-, bromo-, and iodopaclitaxel derivatives: synthesis and biological evaluation. Nucl Med Biol 2003; 30:11–24. <>
8. Pastera J, Květina J, Svoboda Z et al. Attempt of drug targeting using model cytostatic agent and excipient (experimental rabbits). Vojen Zdrav Listy 2001; 62 Suppl: 91–5.
9. Pradier O, Rave-Frank M, Lehmann J et al. Effects of docetaxel in combination with radiation on human head and neck cancer cells (ZMK-1) and cervical squamous cell carcinoma cells (CaSki ). Int J Cancer 2001; 9:840–5. <<::AID-IJC1142>3.0.CO;2-U>
10. Roh EJ, Park YH, Song CE et all. Radiolabeling of paclitaxel with electrophilic 123I. Bioorg Med Chem 2000; 8:65–8. <>
11. Wood KW, Cornwell WD, Jackson JR. Past and future of the mitotic spindle as an oncology target. Curr Opin Pharmacol. 2001; 1:370–7. <>
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