Acta Med. 2006, 49: 113-118

Comparison of Effects of Different Antidotes on Tabun-Induced Cognitive Impairment in Rats Using Water Maze

Gabriela Kunešová, Jiří Kassa

University of Defence, Faculty of Military Health Sciences, Department of Toxicology, Hradec Králové, Czech Republic

Received November 1, 2005
Accepted May 1, 2006

In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals. Recently, they are interested in antidotes able not only to protect nerve agent-poisoned men from lethal toxic effects but also to improve their life quality by improvement of their central cognitive functions. In our study, the water maze was used to measure spatial working learning and memory in the case of tabun-induced cognitive impairment in albino Wistar rats. Antidotal treatment consisted of atropine alone or a combination of atropine with an oxime (obidoxime, trimedoxime or oxime HI-6). Our results suggest that atropine alone is not sufficient as a treatment for saving cognitive functions impaired by tabun. On the other hand, the addition of oxime to atropine contributes to improvement of cognitive performance in tabun-poisoned rats regardless of type of oxime.


The study was supported by the grant of Ministry of Defence of Czech Republic No. OBVLAJEP 20032.


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